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2026 data Public-data reference. official source

Metastatic Renal Cell Carcinoma

Open-data reference.

38 US clinical trials · 14 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 364 participants

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

SWOG Cancer Research Network

NCT04510597

RECRUITING Phase 3 269 participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NRG Oncology

NCT06500455

RECRUITING Phase 2 240 participants

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

NRG Oncology

NCT05327686

RECRUITING Phase 1 224 participants

A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Pfizer

NCT07227415

RECRUITING Phase 2 111 participants

Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors

Fox Chase Cancer Center

NCT05263050

RECRUITING Phase 2 89 participants

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Rahul Aggarwal

NCT03682289

RECRUITING Phase 2 78 participants

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

National Cancer Institute (NCI)

NCT05155033

RECRUITING Phase 2 70 participants

Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC

Karie Runcie

NCT06863311

RECRUITING NA 60 participants

Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney Cancer

Ohio State University Comprehensive Cancer Center

NCT06391099

RECRUITING Phase 1 43 participants

A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)

Memorial Sloan Kettering Cancer Center

NCT06835972

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 2 30 participants

Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibitors (ICI) in Metastatic Renal Cell Carcinoma

Yale University

NCT04974671

RECRUITING Phase 1 28 participants

CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer

Osel

NCT06399419

RECRUITING Phase 2 20 participants

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03786796

ACTIVE NOT RECRUITING Phase 3 819 participants

Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy

National Cancer Institute (NCI)

NCT03055013

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 3 472 participants

Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study

ECOG-ACRIN Cancer Research Group

NCT05863351

ACTIVE NOT RECRUITING 468 participants

Outcomes Database to prospectivelY aSSEss the Changing TherapY Landscape in Renal Cell Carcinoma

Duke University

NCT04919122

ACTIVE NOT RECRUITING Phase 1 145 participants

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy

Nanobiotix

NCT03589339

ACTIVE NOT RECRUITING NA 61 participants

Cancer and Blood Pressure Management, CARISMA Study

ECOG-ACRIN Cancer Research Group

NCT04467021

ACTIVE NOT RECRUITING Phase 2 60 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

National Cancer Institute (NCI)

NCT03284385

ACTIVE NOT RECRUITING Phase 1 59 participants

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT02298959

ACTIVE NOT RECRUITING Phase 2 32 participants

Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma

M.D. Anderson Cancer Center

NCT03541902

ACTIVE NOT RECRUITING Phase 1 31 participants

CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer

City of Hope Medical Center

NCT05122546

ACTIVE NOT RECRUITING Phase 2 30 participants

Ixazomib, Gemcitabine, and Doxorubicin in Treating Patients With Locally Advanced or Metastatic Kidney Cancer

M.D. Anderson Cancer Center

NCT03587662

ACTIVE NOT RECRUITING NA 21 participants

App-Based Mindfulness Intervention for the Improvement of Quality of Life in Patients With Metastatic Renal Cell Cancer

City of Hope Medical Center

NCT04788095

ACTIVE NOT RECRUITING Phase 1 18 participants

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

Megan Daly, MD

NCT03474497

ACTIVE NOT RECRUITING Phase 2 15 participants

A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC)

National Cancer Institute (NCI)

NCT03595124

ACTIVE NOT RECRUITING Phase 2 10 participants

A Phase II Study Bolstering Outcomes by Optimizing Immunotherapy Strategies With Evolocumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma (BOOST-RCC)

M.D. Anderson Cancer Center

NCT06284564

ACTIVE NOT RECRUITING Phase 1 2 participants

A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT06132945

COMPLETED Phase 1 173 participants

A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Treatment

Eisai

NCT01136733

COMPLETED Phase 2 150 participants

Study Using FolateScan to Identify Subjects With Folate Receptor-Positive Metastatic Renal Cell Carcinoma

Endocyte

NCT01689766

COMPLETED Phase 2 123 participants

The High-Dose Aldesleukin (IL-2) "Select" Trial for Patients With Metastatic Renal Cell Carcinoma

Beth Israel Deaconess Medical Center

NCT00554515

COMPLETED Phase 2 115 participants

CRLX101(NLG207) in Combination With Bevacizumab for Metastatic Renal Cell Carcinoma (mRCC) Versus Standard of Care (SOC)

NewLink Genetics Corporation

NCT02187302

COMPLETED Phase 2 39 participants

A Study of Ramucirumab in Participants With Metastatic Renal Cell Carcinoma

Eli Lilly and Company

NCT00515697

COMPLETED NA 22 participants

Serial Ultrasound in Metastatic Renal Cell Carcinoma (mRCC)

Stanford University

NCT04508725

COMPLETED NA 21 participants

Probiotic Yogurt Supplement in Reducing Diarrhea in Patients With Metastatic Kidney Cancer Being Treated With Vascular Endothelial Growth Factor-Tyrosine Kinase Inhibitor

City of Hope Medical Center

NCT02944617

COMPLETED Phase 2 18 participants

Talazoparib and Avelumab in Participants With Metastatic Renal Cell Carcinoma

Memorial Sloan Kettering Cancer Center

NCT04068831

Phase Distribution

PhaseTrial count
Early Phase 1 10
Phase 2 17
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Renal Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 38 US studies indexed under Metastatic Renal Cell Carcinoma, and 14 of those are currently open to recruitment — roughly 37% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Renal Cell Carcinoma shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 27 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Renal Cell Carcinoma is led by National Cancer Institute (NCI) with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 38 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Renal Cell Carcinoma?

PlainTrial tracks 38 US clinical trials for Metastatic Renal Cell Carcinoma, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Renal Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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