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ACTIVE NOT RECRUITING Phase 1

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy

NCT03589339 · View on ClinicalTrials.gov ↗

Study Summary

The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.

Interventions

  • DRUG Pembrolizumab
  • DRUG Nivolumab
  • RADIATION SABR
  • DRUG NBTXR3

Study Locations (13)

Michigan

  • Karmanos Cancer Institute — Detroit
  • Henry Ford Cancer Institute — Detroit

California

  • University of California San Francisco — San Francisco

Florida

  • Moffitt Cancer Center — Tampa

Georgia

  • Emory University — Atlanta

Illinois

  • University of Chicago Medical Center — Chicago

Maryland

  • Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center — Baltimore

New Mexico

  • Christus St. Vincent Regional Cancer Center — Santa Fe

New York

  • Northwell Health — Manhasset

Trial Details

FieldValue
Enrollment Target 145 participants
Start Date 2019-01-16
Est. Completion 2027-08-30
Phase Phase 1

Sponsor

Nanobiotix

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03589339

The ClinicalTrials.gov registry entry for NCT03589339 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 145 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nanobiotix, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Metastatic Renal Cell Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03589339 reports 13 study locations spanning 12 distinct geographic areas — top geographies include Michigan, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03589339 about?

NCT03589339 is a clinical study titled "NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy". The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.

What is the current status of trial NCT03589339?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 145 participants. The study started on 2019-01-16. Estimated completion is 2027-08-30.

What conditions does trial NCT03589339 study?

This clinical trial studies the following conditions: Metastatic Renal Cell Carcinoma, Squamous Cell Carcinoma of Head and Neck, Metastatic Triple-Negative Breast Carcinoma, Immunotherapy, Radiotherapy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03589339?

The interventions under investigation include: Pembrolizumab (DRUG), Nivolumab (DRUG), SABR (RADIATION), NBTXR3 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03589339?

This trial is sponsored by Nanobiotix, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03589339 being conducted?

This trial has 13 study locations across California, Florida, Georgia, Illinois, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial