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NCT03743298 · ClinicalTrials.gov registry record · Phase 1
Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma
A Phase 1 study of Metastatic Melanoma, sponsored by Aivita Biomedical.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 2
- Study locations
NCT03743298: Recruiting Phase 1 study of Metastatic Melanoma, sponsored by Aivita Biomedical.
NCT03743298 is a Phase 1 study of Metastatic Melanoma that is actively recruiting participants, run by Aivita Biomedical. The registered enrollment target is 20 participants, below the 83-participant average among 91 other Metastatic Melanoma trials with a reported enrollment target (76% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03743298, a Phase 1 study of Metastatic Melanoma, is actively recruiting participants, sponsored by Aivita Biomedical.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in patients with measurable metastatic melanoma. The study is open to patients who have either never received treatment for metastatic melanoma or were previously treated with anti-PD-1 with or without anti-CTLA-4 or with enzymatic inhibitors of the BRAF/MEK pathway because of BRAF600E/K mutations, and are about to initiate anti-PD-1 monotherapy. The intent is to treat 14 to 20 patients with the combination of anti-PD-1 and AV-MEL-1.
Conditions Studied
Interventions
- DRUG AV-MEL-1
Study Locations (2)
California
- Jericho Rabago - Irvine
- Hoag Memorial Hospital Presbyterian - Newport Beach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2021-04-21 |
| Est. Completion | 2026-05 |
| Phase | Phase 1 |
What NCT03743298 shows while recruiting
NCT03743298 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 83-participant average among 91 other Metastatic Melanoma trials with a reported enrollment target (76% lower).
The record links to 1 condition, with Metastatic Melanoma appearing as the primary indexed condition, and to 1 intervention - of which AV-MEL-1 is the first listed.
NCT03743298 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03743298 about?
NCT03743298 is a clinical study titled "Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic Melanoma". This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in patients with measurable metastatic melanoma. The study is open to patients who have either never received trea...
What is the current status of trial NCT03743298?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2021-04-21. Estimated completion is 2026-05.
What conditions does trial NCT03743298 study?
This clinical trial studies the following conditions: Metastatic Melanoma.
What interventions are being tested in trial NCT03743298?
The interventions under investigation include: AV-MEL-1 (DRUG).
Who is sponsoring clinical trial NCT03743298?
This trial is sponsored by Aivita Biomedical, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03743298 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03743298's enrollment target sits among peer trials
20 64th of 91 higher than 24 of 91 other Metastatic Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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