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ClinicalTrials.gov 32 recruiting now official registry

Metastatic Melanoma clinical trials

32 of 92 indexed Metastatic Melanoma trials are currently recruiting.

92 US clinical trials · 32 currently recruiting

Metastatic Melanoma is the subject of 92 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 82 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 16 of these trials.

The research picture

Metastatic Melanoma has 92 registered US clinical trials, 32 of them open to new participants right now, about 35% of the total.

32
recruiting participants now
35%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
16
top sponsor: M.D. Anderson Cancer Center
Phase 146Phase 236Phase 34

Active & Recent Trials

92 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 29 participants

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT03175432

ACTIVE NOT RECRUITING Phase 1 27 participants

Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss

M.D. Anderson Cancer Center

NCT03131908

ACTIVE NOT RECRUITING Phase 2 24 participants

Study of Oral Azacitidine (CC-486) in Combination With Pembrolizumab (MK-3475) in Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT02816021

ACTIVE NOT RECRUITING Phase 1 21 participants

Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT05470283

ACTIVE NOT RECRUITING Phase 1 20 participants

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

Mayo Clinic

NCT03021460

ACTIVE NOT RECRUITING Phase 1 19 participants

Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies

National Cancer Institute (NCI)

NCT01364051

ACTIVE NOT RECRUITING Phase 1 18 participants

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

Megan Daly, MD

NCT03474497

ACTIVE NOT RECRUITING Phase 2 18 participants

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

National Cancer Institute (NCI)

NCT02581930

ACTIVE NOT RECRUITING Phase 1 17 participants

Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT05628883

ACTIVE NOT RECRUITING Phase 1 16 participants

Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

National Cancer Institute (NCI)

NCT04557956

ACTIVE NOT RECRUITING Phase 2 16 participants

Abbreviated MAPK Targeted Therapy Plus Pembrolizumab in Melanoma

Massachusetts General Hospital

NCT03149029

ACTIVE NOT RECRUITING Phase 1 15 participants

Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1

Roswell Park Cancer Institute

NCT02650986

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

ACTIVE NOT RECRUITING Phase 1 12 participants

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

National Cancer Institute (NCI)

NCT03816332

ACTIVE NOT RECRUITING Phase 1 10 participants

A Study of LN-144 in People With Metastatic Melanoma to the Brain

Memorial Sloan Kettering Cancer Center

NCT05640193

ACTIVE NOT RECRUITING Phase 1 1 participants

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

Emory University

NCT05341349

COMPLETED 160 participants

Long-term Data Collection for Subjects in MDX-010 Studies

Bristol-Myers Squibb

NCT00928031

COMPLETED Phase 1 140 participants

Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas

National Cancer Institute (NCI)

NCT02304458

COMPLETED Phase 2 133 participants

Phase II Trial of Allovectin-7® for Metastatic Melanoma

Vical

NCT00044356

COMPLETED Phase 2 121 participants

A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)

Incyte Corporation

NCT03679767

COMPLETED Phase 1 115 participants

A Phase I/Ib, Multicenter, Open-Label, Dose Escalation Study of E7080 in Patients With Solid Tumors and in Combination With Temozolomide in Patients With Advanced and/or Metastatic Melanoma

Eisai

NCT00121680

COMPLETED Phase 2 76 participants

Efficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic Melanoma

Eisai

NCT01335009

COMPLETED Phase 2 70 participants

Study of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic Melanoma

SCRI Development Innovations

NCT01014351

COMPLETED Phase 2 52 participants

Docetaxel and Vinorelbine Plus Sargramostim in Metastatic Malignant Melanoma

John P. Fruehauf

NCT00256282

COMPLETED Phase 1 50 participants

Phase I/II Trial of a Long Peptide Vaccine (LPV7) Plus TLR Agonists

Craig L Slingluff, Jr

NCT02126579

COMPLETED Phase 2 41 participants

RFT-5-dgA in Patients With Metastatic Melanoma

University of Texas Southwestern Medical Center

NCT00314093

COMPLETED Phase 1 37 participants

Dose Escalation Study of MLN4924 in Adults With Melanoma

Millennium Pharmaceuticals

NCT01011530

COMPLETED Phase 2 36 participants

Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma

Ludwig Institute for Cancer Research

NCT00679289

COMPLETED Phase 1 35 participants

Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies

Rahul Aggarwal

NCT03590054

COMPLETED Phase 2 33 participants

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanoma

National Cancer Institute (NCI)

NCT01993719

COMPLETED Phase 1 20 participants

The Use of Dendritic Cell/Tumor Hybridomas as a Novel Tumor Vaccine in Patients With Advance Melanoma

Beth Israel Deaconess Medical Center

NCT00626860

COMPLETED 20 participants

Melanoma Biomarker Study

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00348088

COMPLETED Phase 1 20 participants

Phase I/II Study of High-Dose Calcitriol Plus Temodar for Patients With Metastatic Melanoma

Northwestern University

NCT00301067

COMPLETED Phase 2 19 participants

Study of MAGE-3/Melan-A/gp 100/NA17 and rhIL-12 With/Out Low Dose IL-2 in Metastatic Melanoma

University of Chicago

NCT00203879

COMPLETED Phase 2 18 participants

Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanoma

M.D. Anderson Cancer Center

NCT02500576

COMPLETED Phase 2 15 participants

Dendritic Cell Vaccines + Dasatinib for Metastatic Melanoma

Walter J. Storkus

NCT01876212

COMPLETED Phase 1 15 participants

Phase I Clinical Trial of Tremelimumab Plus MEDI3617 in Patients With Unresectable Stage III or Stage IV Melanoma

F. Stephen Hodi, MD

NCT02141542

COMPLETED Phase 1 14 participants

Melanoma Checkpoint and Gut Microbiome Alteration With Microbiome Intervention

Parker Institute for Cancer Immunotherapy

NCT03817125

COMPLETED Phase 1 12 participants

Immunotherapy of Melanoma With Tumor Antigen RNA and Small Inhibitory RNA Transfected Autologous Dendritic Cells

Scott Pruitt

NCT00672542

COMPLETED Phase 2 11 participants

Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanoma

Fred Hutchinson Cancer Center

NCT01807182

COMPLETED Phase 1 8 participants

STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain

M.D. Anderson Cancer Center

NCT01904123

COMPLETED Phase 2 4 participants

Radiation and Combination Immunotherapy for Melanoma

Masonic Cancer Center, University of Minnesota

NCT03850691

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Phase Distribution

PhaseTrial count
Phase 1 46
Phase 2 36
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Melanoma Trial Landscape

92 indexed Metastatic Melanoma studies · 32 recruiting (35%).

Phase mix: 4 late (III/IV) vs 82 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (16 trials), 9 others listed. 42 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Melanoma?

PlainTrial tracks 92 US clinical trials for Metastatic Melanoma, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.