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ClinicalTrials.gov 13 recruiting now official registry

Merkel Cell Carcinoma clinical trials

13 of 27 indexed Merkel Cell Carcinoma trials are currently recruiting.

27 US clinical trials · 13 currently recruiting

Merkel Cell Carcinoma is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 25 in Phase 1-2 (earlier-stage). The most active sponsor is H. Lee Moffitt Cancer Center and Research Institute, running 4 of these trials.

The research picture

Merkel Cell Carcinoma has 27 registered US clinical trials, 13 of them open to new participants right now, about 48% of the total.

13
recruiting participants now
48%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: H. Lee Moffitt Cancer Center and Research Institute
Phase 113Phase 212

Active & Recent Trials

27 total, page 1 of 1

RECRUITING Phase 2 240 participants

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Udai Kammula

NCT03935893

RECRUITING Phase 2 100 participants

Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

M.D. Anderson Cancer Center

NCT02479698

RECRUITING Phase 2 100 participants

EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers

Ohio State University Comprehensive Cancer Center

NCT06223659

RECRUITING Phase 1 90 participants

Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies

Replimune

NCT04349436

RECRUITING Phase 1 72 participants

A Study of CRD3874-SI in People With Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT06021626

RECRUITING Phase 1 60 participants

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

AstraZeneca

NCT07115043

RECRUITING Phase 1 56 participants

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center

NCT05859074

RECRUITING Phase 2 52 participants

Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

M.D. Anderson Cancer Center

NCT05100095

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING NA 20 participants

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

AdventHealth Translational Research Institute

NCT06008977

RECRUITING Phase 2 18 participants

Phase II Study of Peptide Receptor Radionuclide Therapy in Combination With Immunotherapy for Patients With Merkel Cell Cancer

Weill Medical College of Cornell University

NCT05583708

RECRUITING Phase 2 15 participants

Neoadjuvant PD-1 Blockade in Resectable Merkel Cell Carcinoma

Abramson Cancer Center at Penn Medicine

NCT05496036

RECRUITING Phase 2 14 participants

TIL Therapy in cSCC and MCC

Karam Khaddour, MD, MS

NCT07288073

ACTIVE NOT RECRUITING Phase 1 96 participants

A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma

Fujifilm Pharmaceuticals U.S.A.

NCT04047251

ACTIVE NOT RECRUITING Phase 2 50 participants

Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell Carcinoma

H. Lee Moffitt Cancer Center and Research Institute

NCT03071406

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING Phase 1 36 participants

Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell Carcinoma

H. Lee Moffitt Cancer Center and Research Institute

NCT04975152

ACTIVE NOT RECRUITING Phase 2 26 participants

Neoadjuvant Lenvatinib Plus Pembrolizumab in Merkel Cell Carcinoma

H. Lee Moffitt Cancer Center and Research Institute

NCT04869137

ACTIVE NOT RECRUITING Early Phase 1 22 participants

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05358938

ACTIVE NOT RECRUITING Phase 2 18 participants

Study of Avelumab and/or Radiation Therapy in People With Advanced Merkel Cell Carcinoma

Memorial Sloan Kettering Cancer Center

NCT04792073

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

ACTIVE NOT RECRUITING Phase 2 12 participants

Triple Immune Checkpoint Inhibition for Advanced or Metastatic PD-(L)1 Refractory Merkel Cell Carcinoma

University of Washington

NCT06056895

ACTIVE NOT RECRUITING Phase 1 7 participants

BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors

Sotio Biotech

NCT05120271

COMPLETED Phase 1 48 participants

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Arcus Biosciences

NCT03629756

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED NA 29 participants

Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer

Emory University

NCT01526486

COMPLETED Phase 1 7 participants

Nivolumab and Radiation Therapy or Ipilimumab as Adjuvant Therapy in Treating Patients With Merkel Cell Cancer

Claire Verschraegen

NCT03798639

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Merkel Cell Carcinoma Trial Landscape

27 indexed Merkel Cell Carcinoma studies · 13 recruiting (48%).

Phase mix: 0 late (III/IV) vs 25 early (I/II).

Top sponsor: H. Lee Moffitt Cancer Center and Research Institute (4 trials), 9 others listed. 27 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Merkel Cell Carcinoma?

PlainTrial tracks 27 US clinical trials for Merkel Cell Carcinoma, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Merkel Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.