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ClinicalTrials.gov 89 recruiting now official registry

Melanoma clinical trials

89 of 269 indexed Melanoma trials are currently recruiting.

269 US clinical trials · 89 currently recruiting

Melanoma is the subject of 269 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 184 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 20 of these trials.

The research picture

Melanoma has 269 registered US clinical trials, 89 of them open to new participants right now, about 33% of the total.

89
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
20
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1117Phase 267Phase 316Phase 43

Active & Recent Trials

269 total, page 1 of 6

RECRUITING NA 75,000 participants

War on Melanoma™ Public Health & Education Campaign

OHSU Knight Cancer Institute

NCT04611568

RECRUITING 12,000 participants

Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program

M.D. Anderson Cancer Center

NCT01772771

RECRUITING 9,600 participants

Sample Collection for Ongoing Research and Product Evaluation Study

Natera

NCT07318051

RECRUITING 7,000 participants

Evaluation for NCI Surgery Branch Clinical Research Protocols

National Cancer Institute (NCI)

NCT00001823

RECRUITING 3,000 participants

Storage and Research Use of Human Bio-specimens From Melanoma Patients and Clinical Testing for Assignment of Treatment

Vanderbilt-Ingram Cancer Center

NCT01205815

RECRUITING 3,000 participants

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma

National Cancer Institute (NCI)

NCT00040352

RECRUITING 2,000 participants

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Wake Forest University Health Sciences

NCT06418204

RECRUITING 1,152 participants

Well-Being and Health-Related Quality of Life in Melanoma Patients During COVID-19 Pandemic

M.D. Anderson Cancer Center

NCT04474301

RECRUITING NA 1,020 participants

Video Education With Result Dependent dIsclosure

Dana-Farber Cancer Institute

NCT05225428

RECRUITING 1,000 participants

A Storage Facility for Tissues Obtained From Patients With Malignant Melanoma

Ohio State University Comprehensive Cancer Center

NCT04567706

RECRUITING Phase 1 949 participants

A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT04895709

RECRUITING 840 participants

A Prospective Study of Plasma Genotyping as a Noninvasive Biomarker for Genotype-directed Cancer Care

Dana-Farber Cancer Institute

NCT02279004

RECRUITING Phase 2 740 participants

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Daiichi Sankyo

NCT06172478

RECRUITING Phase 3 670 participants

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Iovance Biotherapeutics

NCT05727904

RECRUITING Phase 3 560 participants

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

Regeneron Pharmaceuticals

NCT06246916

RECRUITING 500 participants

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

St. Jude Children's Research Hospital

NCT02775643

RECRUITING NA 480 participants

A Study Evaluating the Integrative Medicine at Home (IM@HOME) Program in People With Cancer

Memorial Sloan Kettering Cancer Center

NCT05053230

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 1 450 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

Genentech

NCT05581004

RECRUITING 400 participants

BostonGene and Exigent Genomic INsight Study

BostonGene

NCT06272864

RECRUITING NA 385 participants

MySmartSkin Online Skin Self-exam Intervention for Melanoma Survivors

Rutgers, The State University of New Jersey

NCT05373823

RECRUITING Phase 1 370 participants

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

Merck Sharp & Dohme

NCT02332668

RECRUITING NA 350 participants

Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients

Mayo Clinic

NCT07379138

RECRUITING Phase 1 316 participants

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

Simcha IL-18

NCT04787042

RECRUITING Phase 1 267 participants

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Pfizer

NCT05355701

RECRUITING NA 252 participants

Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma

M.D. Anderson Cancer Center

NCT03941756

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 1 240 participants

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

Regeneron Pharmaceuticals

NCT06413680

RECRUITING Phase 1 230 participants

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

Nested Therapeutics

NCT06326411

RECRUITING Phase 1 220 participants

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Ipsen

NCT06305247

RECRUITING NA 180 participants

In Vivo Liquid Biopsy of Melanoma (Cytophone)

Cytoastra

NCT06488365

RECRUITING Phase 2 178 participants

A Study of IBI363 in Subjects with Advanced Solid Malignancies

Innovent Biologics (Suzhou) Co.

NCT06281678

RECRUITING Phase 1 176 participants

BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

BioInvent International AB

NCT04752826

RECRUITING Phase 1 174 participants

A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors

Shanghai Henlius Biotech

NCT07160335

RECRUITING Phase 2 170 participants

A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

National Cancer Institute (NCI)

NCT02621021

RECRUITING Phase 2 168 participants

Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma

M.D. Anderson Cancer Center

NCT04594187

RECRUITING Phase 1 160 participants

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

CJ Bioscience

NCT05877430

RECRUITING Phase 1 147 participants

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Children's Oncology Group

NCT04851119

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING 125 participants

Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors

M.D. Anderson Cancer Center

NCT04751396

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING Phase 1 124 participants

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

National Cancer Institute (NCI)

NCT02830724

RECRUITING Phase 2 105 participants

Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma

NYU Langone Health

NCT05428007

RECRUITING Phase 4 100 participants

Dabrafenib and/or Trametinib Rollover Study

Novartis Pharmaceuticals

NCT03340506

RECRUITING 100 participants

Digital Remote Monitoring of Immune Checkpoint Inhibitor Therapy Induced Toxicity Using the Vigilant App

Mayo Clinic

NCT06675643

RECRUITING Phase 1 94 participants

A Study of Nivolumab and Hydroxychloroquine or Nivolumab/Ipilimumab and Hydroxychloroquine in Advanced Melanoma

Ravi Amaravadi, MD

NCT04464759

RECRUITING Phase 2 90 participants

Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT06295159

RECRUITING Phase 2 87 participants

Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients

Vyriad

NCT04291105

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

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Phase Distribution

PhaseTrial count
Phase 1 117
Phase 2 67
Phase 3 16
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma Trial Landscape

269 indexed Melanoma studies · 89 recruiting (33%).

Phase mix: 19 late (III/IV) vs 184 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (20 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma?

PlainTrial tracks 269 US clinical trials for Melanoma, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.