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NCT04594187 · ClinicalTrials.gov registry record · Phase 2
Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma
A Phase 2 study of Melanoma, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 168
- Enrollment target
- 3
- Study locations
NCT04594187: Recruiting Phase 2 study of Melanoma, sponsored by M.D. Anderson Cancer Center.
NCT04594187 is a Phase 2 study of Melanoma that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 168 participants, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (76% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04594187, a Phase 2 study of Melanoma, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 168 participants
- Enrollment target
- 3
- Study locations
Study Summary
This phase II trial seeks to determine the role of nodal radiation therapy after sentinel lymph node biopsy (SLNB) for patients with high risk sentinel lymph node positive melanoma who are planned for immunotherapy without completion lymph node dissection. Prior studies of patients with more advanced melanoma have shown nodal radiation therapy can decrease the risk of nodal recurrence but it is not known if this same benefit will be seen in patients with high risk sentinel lymph node positive disease who are planned for immunotherapy.
Primary Outcome
Regional nodal recurrence will be assessed by physical exam and routine surveillance imaging during follow-up
Conditions Studied
Interventions
- OTHER Quality-of-Life Assessment
- RADIATION Radiation Therapy
- OTHER Immunotherapy
Study Locations (3)
Florida
- Baptist - MD Anderson Cancer Center - Jacksonville
New Jersey
- Cooper Hospital UNIV MED CTR. - Camden
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2021-08-26 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 2 |
What NCT04594187 shows while recruiting
NCT04594187 is an interventional study that assigns participants to a tested intervention. The registered 168 participants enrollment target is mid-sized for trials with a published cap, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (76% lower).
The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 3 interventions - of which Quality-of-Life Assessment is the first listed.
NCT04594187 reports a single indexed study location in Florida, New Jersey, Texas.
Frequently Asked Questions
What is clinical trial NCT04594187 about?
NCT04594187 is a clinical study titled "Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma". This phase II trial seeks to determine the role of nodal radiation therapy after sentinel lymph node biopsy (SLNB) for patients with high risk sentinel lymph node positive melanoma who are planned for immunotherapy without completion lymph node dissection. Prior studies of patients with more advance...
What is the current status of trial NCT04594187?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 168 participants. The study started on 2021-08-26. Estimated completion is 2027-12-31.
What conditions does trial NCT04594187 study?
This clinical trial studies the following conditions: Melanoma.
What interventions are being tested in trial NCT04594187?
The interventions under investigation include: Quality-of-Life Assessment (OTHER), Radiation Therapy (RADIATION), Immunotherapy (OTHER).
Who is sponsoring clinical trial NCT04594187?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04594187 being conducted?
This trial has 3 study locations across Florida, New Jersey, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04594187's enrollment target sits among peer trials
168 82nd of 266 higher than 185 of 266 other Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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