Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01063114 · ClinicalTrials.gov registry record · NA
Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma
A NA study of Brain Tumor and Medulloblastoma, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- NA
- Development phase
- 90
- Enrollment target
- 2
- Study locations
NCT01063114: Completed NA study of Brain Tumor and Medulloblastoma, sponsored by Massachusetts General Hospital.
NCT01063114 is a NA study of Brain Tumor and Medulloblastoma that has completed, run by Massachusetts General Hospital. The registered enrollment target is 90 participants, below the 280-participant average among 69 other Brain Tumor trials with a reported enrollment target (68% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01063114, a NA study of Brain Tumor and Medulloblastoma, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
- 2
- Study locations
Study Summary
There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for CSI. In this study we will be examining the effects of proton beam radiation therapy. Studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. The physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.
Primary Outcome
Cumulative incidence (estimated percentage participants) who experienced ototoxicity defined as either grade 3 or 4 hearing loss in either ear after the completion of radiation therapy in the overall participant population. Cumulative incidence and 95% confidence intervals are shown at 3- and 5-years post RT (radiation treatment)
Conditions Studied
Interventions
- RADIATION proton beam radiation
Study Locations (2)
Massachusetts
- Massachusetts General Hospital - Boston
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2010-04-08 |
| Est. Completion | 2021-11 |
| Phase | NA |
What the finished NCT01063114 record still lists
NCT01063114 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 280-participant average among 69 other Brain Tumor trials with a reported enrollment target (68% lower).
The record links to 3 conditions, with Brain Tumor appearing as the primary indexed condition, and to 1 intervention - of which proton beam radiation is the first listed.
NCT01063114 reports a single indexed study location in Massachusetts, Texas.
Frequently Asked Questions
What is clinical trial NCT01063114 about?
NCT01063114 is a clinical study titled "Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma". There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for...
What is the current status of trial NCT01063114?
This trial is currently completed. It is a NA study. The enrollment target is 90 participants. The study started on 2010-04-08. Estimated completion is 2021-11.
What conditions does trial NCT01063114 study?
This clinical trial studies the following conditions: Brain Tumor, Medulloblastoma, Pineoblastoma.
What interventions are being tested in trial NCT01063114?
The interventions under investigation include: proton beam radiation (RADIATION).
Who is sponsoring clinical trial NCT01063114?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01063114 being conducted?
This trial has 2 study locations across Massachusetts, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Brain Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01063114's enrollment target sits among peer trials
90 21st of 69 higher than 49 of 69 other Brain Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Brain Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)
RECRUITING · NA
-
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
RECRUITING · NA
-
Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption
RECRUITING · NA
-
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
RECRUITING · NA
-
Mapping of Human Cognition
RECRUITING · NA
-
LITT Followed by Hypofractionated RT for Recurrent Gliomas
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02521311 · 90 participants · Phase 2
Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)
- NCT02939573 · 90 participants · Phase 2
A Randomized Multicenter Study for Isolated Skin Vasculitis
- NCT03128879 · 90 participants · Phase 2
Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL
- NCT03184038 · 90 participants · NA
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI