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Major Depressive Disorder (MDD): full-pipeline trial registry
17 of 23 indexed Major Depressive Disorder (MDD) trials are currently recruiting.
Corpus placement: #724 of 28,707 conditions by registered trial count.
23 US clinical trials · 17 currently recruiting · #724 of 28,707 conditions by registered trial count
Major Depressive Disorder (MDD): 23 US clinical trials tracked, 17 recruiting.
Major Depressive Disorder (MDD) is the subject of 23 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Stony Brook University, running 2 of these trials.
Enrollment posture brief
Registry condition major-depressive-disorder-mdd
OPEN 17 | RECR 74% | LATE 6 | EARLY 8 | RANK #724 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Burkitt Lymphoma (74% recruiting · 23 trials)
Major Depressive Disorder (MDD) lists 17 open slots (74% of 23 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Major Depressive Disorder (MDD) on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Major Depressive Disorder (MDD) is recruiting above its size-band peers.
17 of 23 indexed trials (73.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Major Depressive Disorder (MDD) trials is spread across many organizations.
Stony Brook University accounts for 2 of 23 trials (8.7%). 21 distinct sponsors appear on at least one study for this condition label.
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Typical Major Depressive Disorder (MDD) enrolment sits around 80 participants.
Median target enrolment is 80 among the 23 trials that report a genuine target (sentinel values excluded). 12 of those (52.2%) plan for fewer than 100 participants.
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Major Depressive Disorder (MDD) research is mostly interventional.
20 interventional and 3 observational studies make up this index (87% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
23 total, page 1 of 1
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
Vanda Pharmaceuticals
NCT06830044
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
Seaport Therapeutics
NCT07065240
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
NCT06793397
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
Draig Therapeutics
NCT07300969
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
University of Texas Southwestern Medical Center
NCT05966532
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
NCT06624137
Home-Based tDCS Treatment Of Major Depressive Disorder
Sooma Medical
NCT06976697
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
ACADIA Pharmaceuticals
NCT07284667
Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements
Kernel
NCT07294924
Neurofeedback to Treat Depression - 2
University of Pennsylvania
NCT07159061
Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
Children's Hospital Medical Center, Cincinnati
NCT07217444
The Role of mGluR5 in CBT-I
Stony Brook University
NCT07076342
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
Marianne Goodman
NCT06854224
Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
University of California, Davis
NCT07025720
Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
Portland VA Medical Center
NCT06728774
PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.
Stony Brook University
NCT07095205
Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
University of California, San Diego
NCT07217223
Study to Evaluate Efficacy and Safety of Ropanicant in MDD Patients
Suven Life Sciences Limited
NCT06836063
A Study in Patients With Major Depressive Disorder
Chase Therapeutics Corporation
NCT03642964
Effects Of Antidepressants On Sexual Functioning In Adults
GlaxoSmithKline
NCT00051272
Switching From Generic Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) to Three Different Dose Initiation Strategies With Vilazodone
Duke University
NCT02015546
Improving Depression Outcome by Enhancing Memory for Cognitive Therapy
University of California, Berkeley
NCT01790919
Patient Tolerability Study of GSK163090
GlaxoSmithKline
NCT00559299
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 7 |
| Phase 3 | 4 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Major Depressive Disorder (MDD) records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Major Depressive Disorder (MDD) trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Major Depressive Disorder (MDD) page
23 registered trials, 17 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 17 Major Depressive Disorder (MDD) trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Stony Brook University sponsors the most Major Depressive Disorder (MDD) trials on record, review their full trial history before evaluating a specific study. See Stony Brook University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Major Depressive Disorder (MDD) condition card totals 23 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.