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NCT06728774 · ClinicalTrials.gov registry record · NA
Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
A NA study of Cognitive Dysfunction and Major Depressive Disorder (MDD), sponsored by Portland VA Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT06728774 is a NA study of Cognitive Dysfunction and Major Depressive Disorder (MDD) that is actively recruiting participants, run by Portland VA Medical Center. The registered enrollment target is 24 participants, below the 1,992-participant average among 45 other Cognitive Dysfunction trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06728774, a NA study of Cognitive Dysfunction and Major Depressive Disorder (MDD), is actively recruiting participants, sponsored by Portland VA Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Individuals with depression often describe difficulties with memory, attention, concentration, and overall cognitive functioning, which can persist even after mood episodes get better, and can affect treatment and health outcomes. The primary objective of this pilot clinical trial is to evaluate the feasibility and acceptability of a manualized, 8-week, Compensatory Cognitive Training (CCT) intervention for Veterans who received treatment for MDD in the past year and have persistent cognitive functioning deficits. The investigators will compare Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD) to a robust comparator, Goal-focused Supportive Contact (GSC), to evaluate differences in outcome measures. The investigators hypothesize that Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD) will be feasible and acceptable to participants in a pilot trial of ME-CCT-MDD vs. Goal-focused supportive contact (GSC) for Veterans with recent MDD treatment and persistent cognitive symptoms. This study will also evaluate the preliminary magnitude and direction of symptom change on measures of objective cognitive functioning, psychiatric symptomatology, psychosocial functioning, and quality of life. The investigators hypothesize that CCT will improve objective cognitive functioning, psychiatric outcomes, psychosocial functioning, and quality of life in Veterans with recent MDD-related cognitive functioning deficits. Participants who agree to participate in the study will: 1. Take part in an assessment of their cognition, symptoms, and functioning, which will take approximately 2 hours. The assessment will include an interview about their medical, psychiatric, and cognitive history. It will also include questionnaires about their symptoms and daily functioning as well as neuropsychological tests, which are paper-pencil tests that evaluate aspects of cognition such as memory, attentio
Conditions Studied
Interventions
- BEHAVIORAL Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD)
- BEHAVIORAL Goal-focused Supportive Contact
Study Locations (1)
Oregon
- Portland VA Medical Center - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2026-06 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06728774
The ClinicalTrials.gov registry entry for NCT06728774 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,992-participant average among 45 other Cognitive Dysfunction trials with a reported enrollment target (99% lower). The listed sponsor is Portland VA Medical Center, which has 15 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Cognitive Dysfunction appearing as the primary indexed condition, and to 2 interventions - of which Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD) is the first listed.
NCT06728774 reports 1 study location spanning 1 distinct geographic area - top geographies include Oregon.
Frequently Asked Questions
What is clinical trial NCT06728774 about?
NCT06728774 is a clinical study titled "Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits". Individuals with depression often describe difficulties with memory, attention, concentration, and overall cognitive functioning, which can persist even after mood episodes get better, and can affect treatment and health outcomes. The primary objective of this pilot clinical trial is to evaluate th...
What is the current status of trial NCT06728774?
This trial is currently recruiting. It is a NA study. The enrollment target is 24 participants. The study started on 2025-05-01. Estimated completion is 2026-06.
What conditions does trial NCT06728774 study?
This clinical trial studies the following conditions: Cognitive Dysfunction, Major Depressive Disorder (MDD).
What interventions are being tested in trial NCT06728774?
The interventions under investigation include: Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD) (BEHAVIORAL), Goal-focused Supportive Contact (BEHAVIORAL).
Who is sponsoring clinical trial NCT06728774?
This trial is sponsored by Portland VA Medical Center, which has 15 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06728774 being conducted?
This trial has 1 study location across Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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