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NCT07294924 · ClinicalTrials.gov registry record
Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements
A clinical trial of Major Depressive Disorder (MDD) and fNIRS, sponsored by Kernel.
- Recruiting
- Registry status
- 100
- Enrollment target
- 2
- Study locations
NCT07294924: Recruiting study of Major Depressive Disorder (MDD) and fNIRS, sponsored by Kernel.
NCT07294924 is a study of Major Depressive Disorder (MDD) and fNIRS that is actively recruiting participants, run by Kernel. The registered enrollment target is 100 participants, below the 154-participant average among 22 other Major Depressive Disorder (MDD) trials with a reported enrollment target (35% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07294924, a study of Major Depressive Disorder (MDD) and fNIRS, is actively recruiting participants, sponsored by Kernel.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 2
- Study locations
Study Summary
This observational, longitudinal, multi-cohort study aims to evaluate functional brain activity in adults undergoing treatment for Major Depressive Disorder (MDD) at participating clinical sites. A separate cohort of healthy adults will be enrolled as a control group. All data collected in this study are for research purposes only and will not influence clinical decision-making or treatment plans. This study will use TD-fNIRS to measure hemodynamic brain responses at rest and/or during tasks in patients receiving accelerated transcranial magnetic stimulation (TMS). Imaging will occur at multiple timepoints (pre-treatment, post-treatment, and follow-ups). Healthy control participants will complete similar measurements at one visit, with the option for a follow-up visit. The primary objectives are to assess feasibility, characterize brain activity patterns, and explore potential biomarkers associated with treatment response.
Primary Outcome
To gather hemodynamic data with TD-fNIRS and develop biomarkers of depression treatment response and group differences between patients and controls. Candidate markers to relate to clinician assessments are: 1. Local changes in neural activity during Resting State and Task; 2. Functional Connectivity during Resting State and Task; 3. Patterns of Hemodynamic Responses During Emotional, and/or Verbal Fluency Tasks
Conditions Studied
Interventions
- OTHER fNIRS measurement
Study Locations (2)
California
- Kernel - Los Angeles
- Acacia Clinics - Sunnyvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-12-15 |
| Est. Completion | 2026-12-15 |
What NCT07294924 shows while recruiting
NCT07294924 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 154-participant average among 22 other Major Depressive Disorder (MDD) trials with a reported enrollment target (35% lower).
The record links to 2 conditions, with Major Depressive Disorder (MDD) appearing as the primary indexed condition, and to 1 intervention - of which fNIRS measurement is the first listed.
NCT07294924 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07294924 about?
NCT07294924 is a clinical study titled "Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements". This observational, longitudinal, multi-cohort study aims to evaluate functional brain activity in adults undergoing treatment for Major Depressive Disorder (MDD) at participating clinical sites. A separate cohort of healthy adults will be enrolled as a control group. All data collected in this stud...
What is the current status of trial NCT07294924?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2025-12-15. Estimated completion is 2026-12-15.
What conditions does trial NCT07294924 study?
This clinical trial studies the following conditions: Major Depressive Disorder (MDD), fNIRS.
What interventions are being tested in trial NCT07294924?
The interventions under investigation include: fNIRS measurement (OTHER).
Who is sponsoring clinical trial NCT07294924?
This trial is sponsored by Kernel, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07294924 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder (MDD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07294924's enrollment target sits among peer trials
100 11th of 22 higher than 12 of 22 other Major Depressive Disorder (MDD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder (MDD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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