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Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
NCT05966532 · View on ClinicalTrials.gov ↗
Study Summary
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and Magnetoencephalography (MEG)/Magnetic resonance imaging (MRI) procedures at one time point. The investigators will also enroll 120 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. Healthy controls will complete clinical and neurocognitive measures at one time point. To attain a balanced sample of adults across the lifespan, the investigators will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort.
Conditions Studied
Interventions
- BEHAVIORAL Hot Cognitive Task
- BEHAVIORAL Cold cognitive tasks
- OTHER Structural magnetic resonance imaging (sMRI)
- OTHER Magnetoencephalography imaging (MEG)
- BEHAVIORAL four self-report forms per the requirement of the NIH Common Data Elements project
Study Locations (2)
Texas
- University of Texas Arlington — Arlington
- University of Texas Southwestern Medical Center — Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 276 participants |
| Start Date | 2023-12-11 |
| Est. Completion | 2026-08-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05966532
The ClinicalTrials.gov registry entry for NCT05966532 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 276 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Texas Southwestern Medical Center, which has 742 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Major Depressive Disorder (MDD) appearing as the primary indexed condition, and to 5 interventions — of which Hot Cognitive Task is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05966532 reports 2 study locations spanning 1 distinct geographic area — top geographies include Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05966532 about?
NCT05966532 is a clinical study titled "Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression". This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and ...
What is the current status of trial NCT05966532?
This trial is currently recruiting. The enrollment target is 276 participants. The study started on 2023-12-11. Estimated completion is 2026-08-31.
What conditions does trial NCT05966532 study?
This clinical trial studies the following conditions: Major Depressive Disorder (MDD), Healthy Adult Volunteer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05966532?
The interventions under investigation include: Hot Cognitive Task (BEHAVIORAL), Cold cognitive tasks (BEHAVIORAL), Structural magnetic resonance imaging (sMRI) (OTHER), Magnetoencephalography imaging (MEG) (OTHER), four self-report forms per the requirement of the NIH Common Data Elements project (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05966532?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 742 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05966532 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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