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NCT05966532 · ClinicalTrials.gov registry record

Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression

A clinical trial of Major Depressive Disorder (MDD) and Healthy Adult Volunteer, sponsored by University of Texas Southwestern Medical Center.

Recruiting
Registry status
276
Enrollment target
2
Study locations

NCT05966532 is a study of Major Depressive Disorder (MDD) and Healthy Adult Volunteer that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 276 participants, above the 146-participant average among 22 other Major Depressive Disorder (MDD) trials with a reported enrollment target (89% higher). The trial reports 2 study locations across 1 state.

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The verdict

NCT05966532, a study of Major Depressive Disorder (MDD) and Healthy Adult Volunteer, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.

RECRUITING
Registry status
276 participants
Enrollment target
2
Study locations

Study Summary

This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and Magnetoencephalography (MEG)/Magnetic resonance imaging (MRI) procedures at one time point. The investigators will also enroll 120 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. Healthy controls will complete clinical and neurocognitive measures at one time point. To attain a balanced sample of adults across the lifespan, the investigators will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort.

Conditions Studied

Major Depressive Disorder (MDD) Healthy Adult Volunteer

Interventions

  • BEHAVIORAL Hot Cognitive Task
  • BEHAVIORAL Cold cognitive tasks
  • OTHER Structural magnetic resonance imaging (sMRI)
  • OTHER Magnetoencephalography imaging (MEG)
  • BEHAVIORAL four self-report forms per the requirement of the NIH Common Data Elements project

Study Locations (2)

Texas

  • University of Texas Arlington - Arlington
  • University of Texas Southwestern Medical Center - Dallas

Trial Details

FieldValue
Enrollment Target 276 participants
Start Date 2023-12-11
Est. Completion 2026-08-31

Sponsor

University of Texas Southwestern Medical Center

837 total trials

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What the Registry Record Tells You About NCT05966532

The ClinicalTrials.gov registry entry for NCT05966532 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 276 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 146-participant average among 22 other Major Depressive Disorder (MDD) trials with a reported enrollment target (89% higher). The listed sponsor is University of Texas Southwestern Medical Center, which has 837 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Major Depressive Disorder (MDD) appearing as the primary indexed condition, and to 5 interventions - of which Hot Cognitive Task is the first listed.

NCT05966532 reports 2 study locations spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT05966532 about?

NCT05966532 is a clinical study titled "Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression". This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and ...

What is the current status of trial NCT05966532?

This trial is currently recruiting. The enrollment target is 276 participants. The study started on 2023-12-11. Estimated completion is 2026-08-31.

What conditions does trial NCT05966532 study?

This clinical trial studies the following conditions: Major Depressive Disorder (MDD), Healthy Adult Volunteer.

What interventions are being tested in trial NCT05966532?

The interventions under investigation include: Hot Cognitive Task (BEHAVIORAL), Cold cognitive tasks (BEHAVIORAL), Structural magnetic resonance imaging (sMRI) (OTHER), Magnetoencephalography imaging (MEG) (OTHER), four self-report forms per the requirement of the NIH Common Data Elements project (BEHAVIORAL).

Who is sponsoring clinical trial NCT05966532?

This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05966532 being conducted?

This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.