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NCT05966532 · ClinicalTrials.gov registry record
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
A clinical trial of Major Depressive Disorder (MDD) and Healthy Adult Volunteer, sponsored by University of Texas Southwestern Medical Center.
- Recruiting
- Registry status
- 276
- Enrollment target
- 2
- Study locations
NCT05966532: Recruiting study of Major Depressive Disorder (MDD) and Healthy Adult Volunteer, sponsored by University of Texas Southwestern Medical Center.
NCT05966532 is a study of Major Depressive Disorder (MDD) and Healthy Adult Volunteer that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 276 participants, above the 146-participant average among 22 other Major Depressive Disorder (MDD) trials with a reported enrollment target (89% higher). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05966532, a study of Major Depressive Disorder (MDD) and Healthy Adult Volunteer, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.
- RECRUITING
- Registry status
- 276 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and Magnetoencephalography (MEG)/Magnetic resonance imaging (MRI) procedures at one time point. The investigators will also enroll 120 demographically matched comparable, never-depressed healthy participants (controls) to establish cognitive benchmarks. Healthy controls will complete clinical and neurocognitive measures at one time point. To attain a balanced sample of adults across the lifespan, the investigators will enroll participants such that each age epoch (e.g., 21-30, 31-40, etc.) has a total of ten subjects (n=10) in both the healthy control cohort and depressed cohort.
Primary Outcome
Assesses the point of intensity for fascial emotion recognition. Faces are presented with slowly morphing emotional expressions (e.g., happy, sad, angry) that increases (point of detection) or decrease (emotion no longer perceived). Intensity threshold for each emotion and each condition (i.e., increases and decrease).
Conditions Studied
Interventions
- BEHAVIORAL Hot Cognitive Task
- BEHAVIORAL Cold cognitive tasks
- OTHER Structural magnetic resonance imaging (sMRI)
- OTHER Magnetoencephalography imaging (MEG)
- BEHAVIORAL four self-report forms per the requirement of the NIH Common Data Elements project
Study Locations (2)
Texas
- University of Texas Arlington - Arlington
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 276 participants |
| Start Date | 2023-12-11 |
| Est. Completion | 2026-08-31 |
What NCT05966532 shows while recruiting
NCT05966532 is an observational study that tracks outcomes without assigning an intervention. The registered 276 participants enrollment target is mid-sized for trials with a published cap, above the 146-participant average among 22 other Major Depressive Disorder (MDD) trials with a reported enrollment target (89% higher).
The record links to 2 conditions, with Major Depressive Disorder (MDD) appearing as the primary indexed condition, and to 5 interventions - of which Hot Cognitive Task is the first listed.
NCT05966532 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05966532 about?
NCT05966532 is a clinical study titled "Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression". This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD. All participants will undergo clinical and neurocognitive assessment, and ...
What is the current status of trial NCT05966532?
This trial is currently recruiting. The enrollment target is 276 participants. The study started on 2023-12-11. Estimated completion is 2026-08-31.
What conditions does trial NCT05966532 study?
This clinical trial studies the following conditions: Major Depressive Disorder (MDD), Healthy Adult Volunteer.
What interventions are being tested in trial NCT05966532?
The interventions under investigation include: Hot Cognitive Task (BEHAVIORAL), Cold cognitive tasks (BEHAVIORAL), Structural magnetic resonance imaging (sMRI) (OTHER), Magnetoencephalography imaging (MEG) (OTHER), four self-report forms per the requirement of the NIH Common Data Elements project (BEHAVIORAL).
Who is sponsoring clinical trial NCT05966532?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05966532 being conducted?
This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder (MDD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05966532's enrollment target sits among peer trials
276 6th of 22 higher than 17 of 22 other Major Depressive Disorder (MDD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder (MDD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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