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RECRUITING Phase 2

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

NCT07284667 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatment resistant depression (TRD). The main questions the study aims to answer are: * Does ACP-211 work better than a placebo (a look-alike capsule with no medicine) to reduce symptoms of depression? * What adverse events do participants have when taking ACP-211?

Interventions

  • DRUG Placebo
  • DRUG ACP-211

Study Locations (12)

Florida

  • Sandhill Research, LLC/DBA Accel Research Sites — Largo
  • Clinical Neuroscience Solutions, Inc. — Orlando
  • IPTB Clinical Research — Tampa

Texas

  • Dynamed Clinical Research LP d/b/a DM Clinical Research — Houston
  • Olympus Clinical Research, LLC — Katy

California

  • Inland Psychiatric Medical Group — Chino

Colorado

  • Mountain View Clinical Research — Denver

Massachusetts

  • Vitalix Clinical, Inc. — Worcester

Nevada

  • Redbird Research LLC — Las Vegas

New Jersey

  • CenExel Hassman Research Institute, LLC — Marlton

New York

  • Integrative Clinical Trials LLC — Brooklyn

Trial Details

FieldValue
Enrollment Target 153 participants
Start Date 2025-11-14
Est. Completion 2027-09
Phase Phase 2

Sponsor

ACADIA Pharmaceuticals

10 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07284667

The ClinicalTrials.gov registry entry for NCT07284667 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 153 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ACADIA Pharmaceuticals, which has 10 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Major Depressive Disorder (MDD) appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07284667 reports 12 study locations spanning 9 distinct geographic areas — top geographies include Florida, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07284667 about?

NCT07284667 is a clinical study titled "ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response". The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatment resistant depression (TRD). The main questions the study aims to answer are: * Does ACP-211 work...

What is the current status of trial NCT07284667?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 153 participants. The study started on 2025-11-14. Estimated completion is 2027-09.

What conditions does trial NCT07284667 study?

This clinical trial studies the following conditions: Major Depressive Disorder (MDD), Depressive Disorder, Treatment-Resistant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07284667?

The interventions under investigation include: Placebo (DRUG), ACP-211 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07284667?

This trial is sponsored by ACADIA Pharmaceuticals, which has 10 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07284667 being conducted?

This trial has 12 study locations across California, Colorado, Florida, Massachusetts, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial