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ClinicalTrials.gov 3 recruiting now official registry

Lymphoma, Large B-Cell, Diffuse clinical trials

3 of 11 indexed Lymphoma, Large B-Cell, Diffuse trials are currently recruiting.

11 US clinical trials · 3 currently recruiting

Lymphoma, Large B-Cell, Diffuse is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Seagen, running 2 of these trials.

The research picture

Lymphoma, Large B-Cell, Diffuse has 11 registered US clinical trials, 3 of them open to new participants right now, about 27% of the total.

3
recruiting participants now
27%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Seagen
Phase 17Phase 24

Active & Recent Trials

11 total, page 1 of 1

RECRUITING Phase 2 594 participants

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Merck Sharp & Dohme

NCT06890884

RECRUITING Phase 1 439 participants

A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

Janssen Research & Development

NCT05421663

RECRUITING Phase 2 41 participants

A Phase II Study of Glofitamab Plus Polatuzumab-R-CHP for Patients With High-risk Diffuse Large B-cell Lymphoma

Jennifer Crombie, MD

NCT05800366

ACTIVE NOT RECRUITING Phase 1 57 participants

A Safety Study of PF-08046044/SGN-35C in Adults With Advanced Cancers

Seagen, a wholly owned subsidiary of Pfizer

NCT06254495

COMPLETED Phase 2 279 participants

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

National Heart, Lung, and Blood Institute (NHLBI)

NCT02208037

COMPLETED Phase 1 271 participants

Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma

Celgene

NCT01421524

COMPLETED Phase 1 190 participants

A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab

Pfizer

NCT01307267

COMPLETED Phase 1 64 participants

A Safety Study of SGN-CD19A for B-Cell Lymphoma

Seagen

NCT01786135

COMPLETED Phase 2 55 participants

Bone Marrow Transplant From Partially Matched Donors and Nonmyeloablative Conditioning for Blood Cancers (BMT CTN 0603)

Medical College of Wisconsin

NCT00849147

COMPLETED Phase 1 33 participants

Trial to Define the Safety and Tolerability of SGN-40, Rituximab, and Gemcitabine in Patients With DLBCL

Seagen

NCT00655837

COMPLETED Phase 1 32 participants

Study of TRPH-222 in Patients With Relapsed and/or Refractory B-Cell Lymphoma

Triphase Research and Development III

NCT03682796

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lymphoma, Large B-Cell, Diffuse Trial Landscape

11 indexed Lymphoma, Large B-Cell, Diffuse studies · 3 recruiting (27%).

Phase mix: 0 late (III/IV) vs 11 early (I/II).

Top sponsor: Seagen (2 trials), 9 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lymphoma, Large B-Cell, Diffuse?

PlainTrial tracks 11 US clinical trials for Lymphoma, Large B-Cell, Diffuse, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lymphoma, Large B-Cell, Diffuse?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.