Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma

NCT05421663 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 1b/2, multicenter, open-label, study of prizloncabtagene autoleucel (prizlo-cel), an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refractory (r/r) B-Cell non-Hodgkin lymphoma (B-NHL) or frontline high-risk diffuse large B-cell lymphoma (DLBCL).

Interventions

  • BIOLOGICAL Prizloncabtagene autoleucel (Prizlo-Cel)

Study Locations (20)

Other

  • St Vincents Hospital Melbourne — Fitzroy
  • The Alfred Hospital — Melbourne
  • Fiona Stanley Hospital — Murdoch
  • Calvary Mater Newcastle Hospital — Waratah
  • Rigshospitalet — Copenhagen
  • Odense University Hospital — Odense

Tennessee

  • Greco Hainesworth Tennessee Oncology Centers for Research — Nashville
  • Sarah Cannon Research Institute — Nashville

Texas

  • St. David's South Austin Medical Center — Austin
  • Texas Transplant Institute — San Antonio

California

  • City of Hope — Duarte

Colorado

  • Colorado Blood Cancer Institute — Denver

Iowa

  • University of Iowa Hospital and Clinics — Iowa City

Kentucky

  • University of Kentucky Medical Center — Lexington

New Jersey

  • Rutgers Cancer Institute of New Jersey — Piscataway

Trial Details

FieldValue
Enrollment Target 439 participants
Start Date 2022-08-12
Est. Completion 2029-03-12
Phase Phase 1

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05421663

The ClinicalTrials.gov registry entry for NCT05421663 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 439 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Lymphoma, Non-Hodgkin appearing as the primary indexed condition, and to 1 intervention — of which Prizloncabtagene autoleucel (Prizlo-Cel) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05421663 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Tennessee, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05421663 about?

NCT05421663 is a clinical study titled "A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma". This is a Phase 1b/2, multicenter, open-label, study of prizloncabtagene autoleucel (prizlo-cel), an autologous dual targeting chimeric antigen receptor (CAR) T-cell therapy targeting both cluster of differentiation (CD) CD20 and CD19, for the treatment of adult participants with relapsed or refract...

What is the current status of trial NCT05421663?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 439 participants. The study started on 2022-08-12. Estimated completion is 2029-03-12.

What conditions does trial NCT05421663 study?

This clinical trial studies the following conditions: Lymphoma, Non-Hodgkin, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05421663?

The interventions under investigation include: Prizloncabtagene autoleucel (Prizlo-Cel) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05421663?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05421663 being conducted?

This trial has 20 study locations across California, Colorado, Iowa, Kentucky, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial