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2026 data Public-data reference. official source

Atherosclerotic Cardiovascular Disease

Open-data reference.

22 US clinical trials · 6 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 12,800 participants

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Amgen

NCT07037433

RECRUITING Phase 2 2,310 participants

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

CSL Behring

NCT05485961

RECRUITING Phase 3 1,600 participants

The Prevent Coronary Artery Disease Trial

Icahn School of Medicine at Mount Sinai

NCT06494501

RECRUITING Phase 3 599 participants

Pelacarsen Roll-over Extension Program

Novartis Pharmaceuticals

NCT06875973

RECRUITING NA 400 participants

A Pragmatic INitiative for LDL-C Management by a CLinical Pharmacist-Led Team Among Atherosclerotic CardiovascUlar DisEase Patients

Intermountain Health Care

NCT06571162

RECRUITING NA 300 participants

Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure

University of Alabama at Birmingham

NCT06962488

ACTIVE NOT RECRUITING Phase 3 17,004 participants

Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

Novartis Pharmaceuticals

NCT05030428

ACTIVE NOT RECRUITING Phase 3 16,124 participants

A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease

University of Oxford

NCT03705234

ACTIVE NOT RECRUITING Phase 3 9,541 participants

Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease

NewAmsterdam Pharma

NCT05202509

ACTIVE NOT RECRUITING Phase 3 7,297 participants

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial

Amgen

NCT05581303

ACTIVE NOT RECRUITING Phase 4 130 participants

VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Disease

Duke University

NCT06249165

ACTIVE NOT RECRUITING NA 60 participants

The Young Heart Study

Northwell Health

NCT04462159

COMPLETED 49,065 participants

Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)

Brigham and Women's Hospital

NCT07203677

COMPLETED NA 39,480 participants

A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)

Amgen

NCT05378529

COMPLETED NA 1,062 participants

Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease

University of Pennsylvania

NCT03911141

COMPLETED Phase 2 382 participants

An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol

Novartis Pharmaceuticals

NCT03060577

COMPLETED Phase 4 259 participants

Impact of Evolocumab on the Effects of Clopidogrel in Patients With High On-Treatment Platelet Reactivity

University of Florida

NCT03096288

COMPLETED Phase 2 202 participants

A Study to Assess the Effect of AZD0780 on Ambulatory Blood Pressure

AstraZeneca

NCT06692764

COMPLETED Phase 3 123 participants

Cardiovascular Inflammation Reduction Trial - Inflammation Imaging Study

Icahn School of Medicine at Mount Sinai

NCT02576067

COMPLETED 95 participants

A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial Hypercholesterolemia

Novartis

NCT06507852

COMPLETED NA 60 participants

Recipe for Heart Health

University of Florida

NCT04828447

COMPLETED NA 29 participants

Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

National Heart, Lung, and Blood Institute (NHLBI)

NCT04271735

Phase Distribution

PhaseTrial count
Phase 2 3
Phase 3 8
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Atherosclerotic Cardiovascular Disease Trial Landscape

ClinicalTrials.gov lists 22 US studies indexed under Atherosclerotic Cardiovascular Disease, and 6 of those are currently open to recruitment — roughly 27% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Atherosclerotic Cardiovascular Disease shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Atherosclerotic Cardiovascular Disease is led by Amgen with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Atherosclerotic Cardiovascular Disease?

PlainTrial tracks 22 US clinical trials for Atherosclerotic Cardiovascular Disease, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Atherosclerotic Cardiovascular Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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