Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Atherosclerotic Cardiovascular Disease
Open-data reference.
22 US clinical trials · 6 currently recruiting
Active & Recent Trials
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Amgen
NCT07037433
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
CSL Behring
NCT05485961
The Prevent Coronary Artery Disease Trial
Icahn School of Medicine at Mount Sinai
NCT06494501
Pelacarsen Roll-over Extension Program
Novartis Pharmaceuticals
NCT06875973
A Pragmatic INitiative for LDL-C Management by a CLinical Pharmacist-Led Team Among Atherosclerotic CardiovascUlar DisEase Patients
Intermountain Health Care
NCT06571162
Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure
University of Alabama at Birmingham
NCT06962488
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease
Novartis Pharmaceuticals
NCT05030428
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease
University of Oxford
NCT03705234
Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease
NewAmsterdam Pharma
NCT05202509
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
Amgen
NCT05581303
VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Disease
Duke University
NCT06249165
The Young Heart Study
Northwell Health
NCT04462159
Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)
Brigham and Women's Hospital
NCT07203677
A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)
Amgen
NCT05378529
Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease
University of Pennsylvania
NCT03911141
An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol
Novartis Pharmaceuticals
NCT03060577
Impact of Evolocumab on the Effects of Clopidogrel in Patients With High On-Treatment Platelet Reactivity
University of Florida
NCT03096288
A Study to Assess the Effect of AZD0780 on Ambulatory Blood Pressure
AstraZeneca
NCT06692764
Cardiovascular Inflammation Reduction Trial - Inflammation Imaging Study
Icahn School of Medicine at Mount Sinai
NCT02576067
A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial Hypercholesterolemia
Novartis
NCT06507852
Recipe for Heart Health
University of Florida
NCT04828447
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
National Heart, Lung, and Blood Institute (NHLBI)
NCT04271735
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 3 |
| Phase 3 | 8 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atherosclerotic Cardiovascular Disease Trial Landscape
ClinicalTrials.gov lists 22 US studies indexed under Atherosclerotic Cardiovascular Disease, and 6 of those are currently open to recruitment — roughly 27% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Atherosclerotic Cardiovascular Disease shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Atherosclerotic Cardiovascular Disease is led by Amgen with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atherosclerotic Cardiovascular Disease?
PlainTrial tracks 22 US clinical trials for Atherosclerotic Cardiovascular Disease, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atherosclerotic Cardiovascular Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.