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NCT06890884 · ClinicalTrials.gov registry record · Phase 2
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
A Phase 2 study of Lymphoma, Large B-Cell, Diffuse, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 594
- Enrollment target
- 20
- Study locations
NCT06890884 is a Phase 2 study of Lymphoma, Large B-Cell, Diffuse that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 594 participants, above the 146-participant average among 10 other Lymphoma, Large B-Cell, Diffuse trials with a reported enrollment target (307% higher). The trial reports 20 study locations across 12 states.
The verdict
NCT06890884, a Phase 2 study of Lymphoma, Large B-Cell, Diffuse, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 594 participants
- Enrollment target
- 20
- Study locations
Study Summary
Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing. The goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Doxorubicin
- BIOLOGICAL Rituximab
- BIOLOGICAL Zilovertamab vedotin
- BIOLOGICAL Rituximab Biosimilar
Study Locations (20)
Florida
- Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130) - Boca Raton
- Baptist MD Anderson Cancer Center ( Site 0176) - Jacksonville
- Mount Sinai Cancer Center ( Site 0140) - Miami Beach
- Mid Florida Hematology and Oncology Center ( Site 0152) - Orange City
California
- Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135) - Burbank
- Bass Medical Group ( Site 0123) - Walnut Creek
Colorado
- Rocky Mountain Cancer Centers (RMCC) ( Site 8001) - Aurora
- Colorado West Healthcare System-Grand Valley Oncology ( Site 0165) - Grand Junction
Illinois
- University of Chicago Medical Center ( Site 0126) - Chicago
- Illinois Cancer Care ( Site 7005) - Peoria
Iowa
- University of Iowa-Holden Comprehensive Cancer Center ( Site 0139) - Iowa City
- Mission Blood & Cancer Care ( Site 0114) - Waukee
Kentucky
- Saint Elizabeth Medical Center Edgewood ( Site 0141) - Edgewood
- Baptist Health Hardin ( Site 0154) - Elizabethtown
Alabama
- Infirmary Cancer Care ( Site 0157) - Mobile
Arizona
- Palo Verde Cancer Specialists ( Site 0105) - Glendale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 594 participants |
| Start Date | 2025-04-11 |
| Est. Completion | 2032-12-16 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06890884
The ClinicalTrials.gov registry entry for NCT06890884 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 594 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 146-participant average among 10 other Lymphoma, Large B-Cell, Diffuse trials with a reported enrollment target (307% higher). The listed sponsor is Merck Sharp & Dohme, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Lymphoma, Large B-Cell, Diffuse appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT06890884 reports 20 study locations spanning 12 distinct geographic areas - top geographies include Florida, California, Colorado.
Frequently Asked Questions
What is clinical trial NCT06890884 about?
NCT06890884 is a clinical study titled "A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)". Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing. The goal of this study is to learn if more people wh...
What is the current status of trial NCT06890884?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 594 participants. The study started on 2025-04-11. Estimated completion is 2032-12-16.
What conditions does trial NCT06890884 study?
This clinical trial studies the following conditions: Lymphoma, Large B-Cell, Diffuse.
What interventions are being tested in trial NCT06890884?
The interventions under investigation include: Cyclophosphamide (DRUG), Doxorubicin (DRUG), Rituximab (BIOLOGICAL), Zilovertamab vedotin (BIOLOGICAL), Rituximab Biosimilar (BIOLOGICAL).
Who is sponsoring clinical trial NCT06890884?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06890884 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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