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ClinicalTrials.gov 31 recruiting now official registry

Low Back Pain clinical trials

31 of 123 indexed Low Back Pain trials are currently recruiting.

123 US clinical trials · 31 currently recruiting

Low Back Pain is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Utah, running 8 of these trials.

The research picture

Low Back Pain has 123 registered US clinical trials, 31 of them open to new participants right now, about 25% of the total.

31
recruiting participants now
25%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
8
top sponsor: University of Utah
Phase 17Phase 25Phase 312Phase 48

Active & Recent Trials

123 total, page 3 of 3

COMPLETED Phase 3 48 participants

A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome

Northwestern University

NCT02478437

COMPLETED NA 46 participants

Regional Manual Therapy and Motor Control Exercise for Chronic Low Back Pain

University of Texas Southwestern Medical Center

NCT02170753

COMPLETED NA 44 participants

Translation of Robotic Apparel for Alleviating Low Back Pain

Boston University Charles River Campus

NCT05736393

COMPLETED Phase 2 41 participants

D-cycloserine in the Management of Chronic Low Back Pain

Thomas J. Schnitzer

NCT00125528

COMPLETED NA 40 participants

Effects of Spinal Stabilization Exercises on Dynamic Balance and Functional Performance in Adults With Low Back Pain

Texas Woman's University

NCT03597191

COMPLETED NA 40 participants

Care Outcomes for Chiropractic Outpatient Veterans

Palmer College of Chiropractic

NCT03254719

COMPLETED Phase 4 38 participants

Brain Imaging of Lidoderm for Chronic Back Pain

Northwestern University

NCT01515540

COMPLETED 38 participants

Multiplanar Lumbopelvic Control in Patients With Low Back Pain

Regis University

NCT02089321

COMPLETED Phase 1 30 participants

Battlefield Acupuncture for the Treatment of Low Back Pain in the Emergency Department

Icahn School of Medicine at Mount Sinai

NCT02399969

COMPLETED NA 30 participants

Manual Unloading of the Lumbar Spine: Can it Predict Responders to Mechanical Traction?

UConn Health

NCT02026076

COMPLETED NA 30 participants

Cryoneurolysis for Facet Mediated Chronic Low Back Pain

Medical Pain Management Services, P

NCT06016127

COMPLETED 30 participants

Soleus H-Reflex in Different Sitting Postures

Texas Woman's University

NCT01744899

COMPLETED NA 30 participants

Trial of Scrambler Therapy or Sham Treatment for Low Back Pain

Virginia Commonwealth University

NCT01896687

COMPLETED 28 participants

Innovative Imaging of Cerebrum and Muscle (iCAM) Repeatability Study

Ohio University

NCT03548168

COMPLETED Early Phase 1 28 participants

Intraarticular Lumbar Joint Corticosteroid Injection(s) as a Treatment of Chronic Low Back Pain in a Selected Population

University of Florida

NCT01382771

COMPLETED NA 26 participants

Soft Tissue Mobilization for Lumbopelvic Pain in the Third Trimester of Pregnancy

Texas Tech University Health Sciences Center

NCT03433404

COMPLETED NA 24 participants

Hip-spine Intervention for Older Adults With Chronic Low Back Pain

University of Delaware

NCT03031158

COMPLETED 23 participants

Misoprostol for Spinal Stenosis

Dallas VA Medical Center

NCT04611464

COMPLETED NA 16 participants

Feasibility of Using Functional Progression to Guide the Treatment of Adolescent Low Back Pain

Nationwide Children's Hospital

NCT02861456

COMPLETED NA 12 participants

measurINg forceS durInG cHiropractic Treatment

Palmer College of Chiropractic

NCT02409797

COMPLETED NA 12 participants

Veteran Ear Acupuncture Pilot Project

Chillicothe VA Medical Center

NCT04208659

COMPLETED NA 10 participants

FDG PET/MRI Evaluation of Facet Joint Pain

Mayo Clinic

NCT02921490

COMPLETED NA 8 participants

PRoGReSS-PS: Patient Response to GRraded Sensory Stimulation: A Pilot Study

Palmer College of Chiropractic

NCT01842737

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 5
Phase 3 12
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Low Back Pain Trial Landscape

123 indexed Low Back Pain studies · 31 recruiting (25%).

Phase mix: 20 late (III/IV) vs 12 early (I/II).

Top sponsor: University of Utah (8 trials), 9 others listed. 23 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Low Back Pain?

PlainTrial tracks 123 US clinical trials for Low Back Pain, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Low Back Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.