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Knee Pain Chronic
Open-data reference.
19 US clinical trials · 10 currently recruiting
Active & Recent Trials
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
SMART Embedded Intervention for Military Postsurgical Engagement Readiness
University of Utah
NCT05050409
BioPoly® Partial Resurfacing Knee Implant IDE
BioPoly
NCT06915363
Optimizing Pain Self-Management in Total Knee Arthroplasty
University of Virginia
NCT06038240
Pain Reprocessing Therapy in Post-Operative Knee Pain
University of Colorado, Denver
NCT06800209
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
LifeBridge Health
NCT04814082
Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees with Chronic Knee Symptoms
Marquette University
NCT06734052
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
University of Texas, El Paso
NCT06105788
Transcranial Direct Current Stimulation in Conjunction with Individualized Physical Therapy for Individuals with Chronic Knee Pain
University of Illinois at Chicago
NCT06132412
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Kessler Foundation
NCT05596591
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
HFIT Versus TENS Study for Chronic Low Back and Knee Pain
Hinge Health
NCT05821530
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
Medacta U
NCT03211663
Maximizing Patient Goal Attainment
Dartmouth-Hitchcock Medical Center
NCT05652270
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty
Mayo Clinic
NCT04028947
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
Kenneth B Chapman
NCT05103527
Gold Factor on Knee Joint Health and Function
4Life Research
NCT05347602
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Knee Pain Chronic Trial Landscape
ClinicalTrials.gov lists 19 US studies indexed under Knee Pain Chronic, and 10 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Knee Pain Chronic shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Knee Pain Chronic is led by Zimmer Biomet with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 19 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Knee Pain Chronic?
PlainTrial tracks 19 US clinical trials for Knee Pain Chronic, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Knee Pain Chronic?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.