Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Knee Pain Chronic: early-phase trial registry
10 of 19 indexed Knee Pain Chronic trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #902 of 28,707 conditions by registered trial count.
19 US clinical trials · 10 currently recruiting · #902 of 28,707 conditions by registered trial count
Knee Pain Chronic: 19 US clinical trials tracked, 10 recruiting.
Knee Pain Chronic is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 4 of these trials.
Enrollment posture brief
Registry condition knee-pain-chronic
OPEN 10 | RECR 53% | LATE 0 | EARLY 1 | RANK #902 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Colorectal Cancer Metastatic (53% recruiting · 19 trials)
Knee Pain Chronic lists 10 open slots (53% of 19 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Knee Pain Chronic on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Knee Pain Chronic is recruiting above its size-band peers.
10 of 19 indexed trials (52.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Knee Pain Chronic research.
Zimmer Biomet accounts for 4 of 19 trials (21.1%). 16 distinct sponsors appear on at least one study for this condition label.
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Typical Knee Pain Chronic enrolment sits around 152 participants.
Median target enrolment is 152 among the 19 trials that report a genuine target (sentinel values excluded). 5 of those (26.3%) plan for fewer than 100 participants.
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Knee Pain Chronic research is mostly interventional.
17 interventional and 2 observational studies make up this index (89.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
19 total, page 1 of 1
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
SMART Embedded Intervention for Military Postsurgical Engagement Readiness
University of Utah
NCT05050409
BioPoly® Partial Resurfacing Knee Implant IDE
BioPoly
NCT06915363
Optimizing Pain Self-Management in Total Knee Arthroplasty
University of Virginia
NCT06038240
Pain Reprocessing Therapy in Post-Operative Knee Pain
University of Colorado, Denver
NCT06800209
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
LifeBridge Health
NCT04814082
Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees with Chronic Knee Symptoms
Marquette University
NCT06734052
Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
University of Texas, El Paso
NCT06105788
Transcranial Direct Current Stimulation in Conjunction with Individualized Physical Therapy for Individuals with Chronic Knee Pain
University of Illinois at Chicago
NCT06132412
Focused Extracorporeal Shockwave Therapy for Knee Arthritis
Kessler Foundation
NCT05596591
Persona Total Knee Arthroplasty Outcomes Study
Zimmer Biomet
NCT02255383
HFIT Versus TENS Study for Chronic Low Back and Knee Pain
Hinge Health
NCT05821530
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
Medacta U
NCT03211663
Maximizing Patient Goal Attainment
Dartmouth-Hitchcock Medical Center
NCT05652270
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty
Mayo Clinic
NCT04028947
Dorsal Root Ganglion Stimulation for the Treatment of Arthritic Knee Pain
Kenneth B Chapman
NCT05103527
Gold Factor on Knee Joint Health and Function
4Life Research
NCT05347602
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Knee Pain Chronic records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Knee Pain Chronic trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Knee Pain Chronic page
19 registered trials, 10 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 10 Knee Pain Chronic trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Knee Pain Chronic trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Knee Pain Chronic condition card totals 19 registered trials; most-linked intervention Gold Factor (Gold Nanoparticles, AuNPs); top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.