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ClinicalTrials.gov 1 recruiting now official registry

Acute Heart Failure clinical trials

1 of 9 indexed Acute Heart Failure trials are currently recruiting.

9 US clinical trials · 1 currently recruiting

Acute Heart Failure is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 2 of these trials.

The research picture

Acute Heart Failure has 9 registered US clinical trials, 1 of them open to new participants right now, about 11% of the total.

1
recruiting participants now
11%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: Vanderbilt University Medical Center
Phase 11Phase 21Phase 33

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Phase 3 5,200 participants

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

Colorado Prevention Center

NCT06008197

ACTIVE NOT RECRUITING 2,800 participants

Improving Diagnostic Accuracy for Acute Heart Failure

Vanderbilt University Medical Center

NCT04886128

ACTIVE NOT RECRUITING Phase 2 474 participants

Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)

Vanderbilt University Medical Center

NCT04481919

COMPLETED Phase 3 1,300 participants

Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure.

Abbott

NCT00348504

COMPLETED 835 participants

Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE Study)

Vanderbilt University

NCT00911703

COMPLETED Phase 3 735 participants

Tezosentan in Acute Heart Failure

Idorsia Pharmaceuticals

NCT00525707

COMPLETED NA 186 participants

Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department

Unity Health Toronto

NCT01193998

COMPLETED NA 51 participants

An Observational Study of the Functional Capacity of Heart Failure

Bristol-Myers Squibb

NCT02350114

COMPLETED Phase 1 40 participants

Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot

Adrian Hernandez

NCT02877095

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 1
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Heart Failure Trial Landscape

9 indexed Acute Heart Failure studies · 1 recruiting (11%).

Phase mix: 3 late (III/IV) vs 2 early (I/II).

Top sponsor: Vanderbilt University Medical Center (2 trials), 7 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Heart Failure?

PlainTrial tracks 9 US clinical trials for Acute Heart Failure, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Heart Failure?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.