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ClinicalTrials.gov 1 recruiting now full pipeline small index

Acute Heart Failure: full-pipeline trial registry

1 of 9 indexed Acute Heart Failure trials are currently recruiting.

Corpus placement: #1,916 of 28,707 conditions by registered trial count.

9 US clinical trials · 1 currently recruiting · #1,916 of 28,707 conditions by registered trial count

Acute Heart Failure: 9 US clinical trials tracked, 1 recruiting.

Acute Heart Failure is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 2 of these trials.

Enrollment posture brief

Registry condition acute-heart-failure

OPEN 1 | RECR 11% | LATE 3 | EARLY 2 | RANK #1916 | SPON 2

Nearest open-share peer: Alcohol Use Disorders (11% recruiting · 9 trials)

Acute Spinal Cord Injury88.9%Acute Lymphoblastic Leukemia55.6%Acute Respiratory Distress S55.6%Acute Otitis Media22.2%Acute Heart Failure (this)11%
Open-enrollment share among volume-matched conditions near Acute Heart Failure

Acute Heart Failure lists 1 open slots (11% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Acute Heart Failure on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Acute Heart Failure is recruiting below its size-band peers.

    1 of 9 indexed trials (11.1%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Acute Heart Failure research.

    Vanderbilt University Medical Center accounts for 2 of 9 trials (22.2%). 8 distinct sponsors appear on at least one study for this condition label.

  3. Typical Acute Heart Failure enrolment sits around 735 participants.

    Median target enrolment is 735 among the 9 trials that report a genuine target (sentinel values excluded). 2 of those (22.2%) plan for fewer than 100 participants.

  4. Acute Heart Failure research is mostly interventional.

    7 interventional and 2 observational studies make up this index (77.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 11Phase 21Phase 33

Open and recent trials

9 total, page 1 of 1

RECRUITING Phase 3 5,200 participants

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

Colorado Prevention Center

NCT06008197

ACTIVE NOT RECRUITING 2,800 participants

Improving Diagnostic Accuracy for Acute Heart Failure

Vanderbilt University Medical Center

NCT04886128

ACTIVE NOT RECRUITING Phase 2 474 participants

Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)

Vanderbilt University Medical Center

NCT04481919

COMPLETED Phase 3 1,300 participants

Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure.

Abbott

NCT00348504

COMPLETED 835 participants

Determining When Patients Hospitalized With Acute Heart Failure Can Be Safely Sent Home (The DECIDE Study)

Vanderbilt University

NCT00911703

COMPLETED Phase 3 735 participants

Tezosentan in Acute Heart Failure

Idorsia Pharmaceuticals

NCT00525707

COMPLETED NA 186 participants

Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department

Unity Health Toronto

NCT01193998

COMPLETED NA 51 participants

An Observational Study of the Functional Capacity of Heart Failure

Bristol-Myers Squibb

NCT02350114

COMPLETED Phase 1 40 participants

Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot

Adrian Hernandez

NCT02877095

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 1
Phase 3 3

Named interventions

Most-linked intervention names on Acute Heart Failure records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

dobutamine Drug
1 trials
Treatment as per usual care Other
1 trials
Treatment as per model probability Other
1 trials
tezosentan Drug
1 trials
levosimendan Drug
1 trials
6 Minute Walk Test Procedure
1 trials
Protocolized diuretic therapy Drug
1 trials
Furosemide Drug
1 trials

US sites by state

Facility locations filed on Acute Heart Failure trials. A trial with sites in several states counts in each.

Tennessee 4 trials
Ohio 4 trials
North Carolina 2 trials
Minnesota 2 trials
Michigan 2 trials
Massachusetts 2 trials
Indiana 2 trials
Illinois 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Acute Heart Failure page

9 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Acute Heart Failure condition card totals 9 registered trials; most-linked intervention dobutamine; top US site state Tennessee. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.