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2026 data Public-data reference. official source

Hypertriglyceridemia

Open-data reference.

27 US clinical trials · 3 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 869 participants

Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

Arrowhead Pharmaceuticals

NCT06822790

RECRUITING Early Phase 1 80 participants

Differential Thrombogenesis by EPA and DHA Mediated by HDL

The Miriam Hospital

NCT06494488

RECRUITING Phase 2 30 participants

A Mechanistic Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Marea Therapeutics

NCT07199309

ACTIVE NOT RECRUITING Phase 3 1,456 participants

Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia

Arrowhead Pharmaceuticals

NCT06347133

ACTIVE NOT RECRUITING Phase 2 216 participants

Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Marea Therapeutics

NCT07028749

ACTIVE NOT RECRUITING Phase 1 108 participants

Study of RN0361in Adult Healthy Subjects and Adult Hypertriglyceridemic Subjects

Ikaria Bioscience Pty

NCT06471543

ACTIVE NOT RECRUITING Phase 2 40 participants

MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia

MediciNova

NCT05464784

COMPLETED Phase 3 646 participants

[E]PANOVA Combined With a [S]TATIN in [P]ATIENTS With HYPERT[R]IGLYCER[I]DEMIA to Reduce Non-HDL CHOLES[T]EROL

AstraZeneca

NCT01408303

COMPLETED Phase 3 160 participants

A Study Comparing The Efficacy & Safety Of Torcetrapib/Atorvastatin And Atorvastatin In Subjects With High Triglycerides

Pfizer

NCT00134498

COMPLETED NA 125 participants

Effects of Amino Acids on Regional Lipid Metabolism

University of Arkansas

NCT01150188

COMPLETED Phase 1 114 participants

Study to Evaluate the 2-Way Interaction Between Multiple Doses of Epanova™ and a Single Dose of Rosuvastatin (Crestor®)

AstraZeneca

NCT02859129

COMPLETED NA 102 participants

Effects of Omega-3 Fatty Acids on Markers of Inflammation

Stanford University

NCT01129050

COMPLETED Phase 2 99 participants

Pilot Study To Assess CAT-2003 in Patients With Hyperlipidemia

Catabasis Pharmaceuticals

NCT01912560

COMPLETED Phase 1 52 participants

Interaction of Epanova on Warfarin Pharmacokinetic and Anticoagulant Activity and Comparison of the Effects of Epanova and Lovaza on Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) After Low-fat Meals

AstraZeneca

NCT01431690

COMPLETED Phase 1 52 participants

The Effect of Multiple Doses of Epanova® on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects

AstraZeneca

NCT01486433

COMPLETED 39 participants

Predictors of Response to Fenofibrate

University of Alabama at Birmingham

NCT01023750

COMPLETED Phase 4 36 participants

Boosted Lexiva With Lovaza Adjunctive Therapy in Hypertriglyceridemic, HIV-Infected Subjects

Felizarta, Franco, M.D.

NCT01010399

COMPLETED Phase 1 32 participants

PK Study Comparing Metformin Eicosapentaenoate to a Combined Dose of Metformin Hydrochloride and Ethyl Ester EPA

Thetis Pharmaceuticals

NCT02113163

COMPLETED NA 30 participants

Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00046267

COMPLETED NA 28 participants

Vascular and Lipid Effects of Omega-3 Fatty Acids in People With Moderately Elevated Triglycerides

Penn State University

NCT00504309

COMPLETED Phase 1 27 participants

Effect of Maraviroc on Metabolic Function in Obese Subjects (Phase I)

Washington University School of Medicine

NCT01133210

COMPLETED NA 20 participants

Effects of Diet Interventions on Monocytes in Metabolic Syndrome

Baylor College of Medicine

NCT03591588

COMPLETED Phase 3 20 participants

Changes in Lipids and Safety of Raltegravir in HIV+ Patients With Hyperlipidemia While on Current Standard Therapy

The Miriam Hospital

NCT00887653

COMPLETED Phase 2 16 participants

Pilot Study To Assess CAT-2003 in Patients With Severe Hypertriglyceridemia

Catabasis Pharmaceuticals

NCT01968720

COMPLETED Phase 1 5 participants

Study of Gemcabene in Adults With FPLD

Elif Oral

NCT03508687

COMPLETED NA 4 participants

Novel Therapies for Metabolic Complications of Lipodystrophies

University of Texas Southwestern Medical Center

NCT00457938

COMPLETED

Regulation of Sterol Homeostasis

US Department of Veterans Affairs

NCT00018720

Phase Distribution

PhaseTrial count
Early Phase 1 8
Phase 2 5
Phase 3 5
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hypertriglyceridemia Trial Landscape

ClinicalTrials.gov lists 27 US studies indexed under Hypertriglyceridemia, and 3 of those are currently open to recruitment — roughly 11% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hypertriglyceridemia shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hypertriglyceridemia is led by AstraZeneca with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 27 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hypertriglyceridemia?

PlainTrial tracks 27 US clinical trials for Hypertriglyceridemia, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hypertriglyceridemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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