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2026 data Public-data reference. official source

Hyperlipidemia

Open-data reference.

36 US clinical trials · 4 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 975 participants

A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

Merck Sharp & Dohme

NCT07216482

RECRUITING NA 100 participants

Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease

Colorado Prevention Center

NCT07334834

RECRUITING NA 90 participants

Inspire HER: Inspiring the Heart and Emotions for Radical Health

University of Alabama at Birmingham

NCT06966258

RECRUITING NA 20 participants

Targeting Metabolic Syndrome From the Emergency Department Through Mixed-Methods: Pilot Trial

Indiana University

NCT07119658

ACTIVE NOT RECRUITING Phase 2 29 participants

Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262806

ACTIVE NOT RECRUITING Phase 3 24 participants

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT02262832

COMPLETED NA 3,188 participants

Body Worlds 3 Nutrition Display

Oregon Health and Science University

NCT00669500

COMPLETED NA 3,000 participants

Improving Quality With Outpatient Decision Support

Agency for Healthcare Research and Quality (AHRQ)

NCT00225628

COMPLETED Phase 3 1,100 participants

A Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease

Pfizer

NCT00134173

COMPLETED Phase 4 1,000 participants

Cholesterol and Pharmacogenetic Study

UCSF Benioff Children's Hospital Oakland

NCT00451828

COMPLETED Phase 2 631 participants

LAPLACE-TIMI 57: Low-density Lipoprotein Cholesterol (LDL-C) Assessment With PCSK9 monoclonaL Antibody Inhibition Combined With Statin thErapy

Amgen

NCT01380730

COMPLETED NA 479 participants

Unmet Social Needs Study

VA Office of Research and Development

NCT04977583

COMPLETED NA 400 participants

The Health Access and Recovery Peer Program

Emory University

NCT01725815

COMPLETED Phase 3 331 participants

Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2

Amgen

NCT01763918

COMPLETED Phase 2 303 participants

The SCCS Polypill Pilot Trial

Vanderbilt University

NCT02278471

COMPLETED Phase 2 261 participants

Effects of Resistance and Aerobic Exercise on Cardiovascular Health

Duke University

NCT00275145

COMPLETED Phase 2 260 participants

Evaluate Low Doses of AEGR-733 on Hepatic Fat Accumulation by MRS

Aegerion Pharmaceuticals

NCT00559962

COMPLETED NA 254 participants

Veterans Walk for Health Study

US Department of Veterans Affairs

NCT00123435

COMPLETED NA 200 participants

Federal Study of Adherence to Medications in the Elderly (FAME)

Walter Reed Army Medical Center

NCT00393419

COMPLETED NA 196 participants

Eating Peanuts for Health

Purdue University

NCT01886326

COMPLETED Phase 3 169 participants

Effects of Colesevelam HCl, Rosiglitazone, Sitagliptin on Control of Blood Glucose and Lipids in Type 2 Diabetes Patients Whose Blood Glucose Isn't Completely Controlled With Metformin

Daiichi Sankyo

NCT00484419

COMPLETED Phase 2 160 participants

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects

Amgen

NCT01375764

COMPLETED Phase 3 156 participants

Low Carbohydrate Diet Compared to Calorie and Fat Restricted Diet in Patients With Obesity and Type II Diabetes

US Department of Veterans Affairs

NCT00108459

COMPLETED Phase 4 140 participants

Colesevelam Treatment for Impaired Fasting Glucose During Niacin Therapy

Radiant Research

NCT01239004

COMPLETED NA 135 participants

Expanding Comparative Effectiveness Research (CER) Capability Through Complex Patient Relationship Management

Denver Health and Hospital Authority

NCT01391585

COMPLETED Phase 1 120 participants

Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of K-312 in Healthy Subjects

Kowa Research Institute

NCT02676596

COMPLETED Phase 2 116 participants

Efficacy and Safety Study of Lipid-Lowering Effects of XueZhiKang (XZK) in Patients With Hyperlipidemia

Beijing Peking University WBL Biotech Co.

NCT01327014

COMPLETED NA 80 participants

Evaluation of Pharmacist Interventions in Lipid Management for Secondary Prevention

Wake Forest University Health Sciences

NCT06647238

COMPLETED Phase 2 80 participants

Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress

University of Mississippi Medical Center

NCT01267227

COMPLETED Phase 4 70 participants

Telephone Based Management of Hyperlipidemia

Temple University

NCT01212159

COMPLETED NA 60 participants

The Triglyceride Lowering Effect of an Omega-3 Fat (DHA) in Addition to Statin Therapy for Patients With CAD or Diabetes

Maine Center for Lipids and Cardiovascular Health

NCT00360217

COMPLETED NA 50 participants

Effects of Use of a Connected Pillbox On Medication Adherence

University of Pennsylvania

NCT02593032

COMPLETED Phase 3 50 participants

Switch to Atazanavir and Brachial Artery Reactivity (SABAR) Study

Northwestern University

NCT00225017

COMPLETED Phase 1 20 participants

Antihyperlipidemic Effects of Oyster Mushrooms

National Center for Complementary and Integrative Health (NCCIH)

NCT00069524

COMPLETED Phase 3 20 participants

Changes in Lipids and Safety of Raltegravir in HIV+ Patients With Hyperlipidemia While on Current Standard Therapy

The Miriam Hospital

NCT00887653

COMPLETED NA 9 participants

Biosynthesis of PGD2 in Vivo

University of Pennsylvania

NCT01275300

Phase Distribution

PhaseTrial count
Early Phase 1 2
Phase 2 8
Phase 3 8
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hyperlipidemia Trial Landscape

ClinicalTrials.gov lists 36 US studies indexed under Hyperlipidemia, and 4 of those are currently open to recruitment — roughly 11% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hyperlipidemia shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 10 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hyperlipidemia is led by Amgen with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 36 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hyperlipidemia?

PlainTrial tracks 36 US clinical trials for Hyperlipidemia, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hyperlipidemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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