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RECRUITING Phase 3

A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)

NCT07216482 · View on ClinicalTrials.gov ↗

Study Summary

Researchers designed a study medicine called enlicitide to lower low-density lipoprotein cholesterol (LDL-C). In this study, researchers want to learn about giving enlicitide with another medicine called rosuvastatin. Rosuvastatin is a standard (usual) treatment to lower LDL-C. The goal of this study is to learn if enlicitide given with rosuvastatin works better than placebo on lowering LDL-C in a person's blood. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of a study medicine.

Conditions Studied

Interventions

  • DRUG Rosuvastatin
  • DRUG Enlicitide
  • DRUG Placebo for Enlicitide
  • DRUG Placebo for Rosuvastatin

Study Locations (20)

Florida

  • Alliance for Multispecialty Research, LLC ( Site 0040) — Fort Myers
  • Soffer Health Institute ( Site 0046) — Hollywood
  • East Coast Institute for Research ( Site 0041) — Lake City
  • Inpatient Research Clinic ( Site 0017) — Miami Lakes
  • Clinical Research Trials of Florida ( Site 0001) — Tampa
  • Clinical Site Partners LLC, dba CSP Orlando ( Site 0014) — Winter Park

Alabama

  • Central Research Associates ( Site 0009) — Birmingham
  • G&L Research ( Site 0024) — Foley

Arizona

  • Synexus Clinical Research US, Inc. - Phoenix Central ( Site 0030) — Phoenix
  • Alliance for Multispecialty Research LLC ( Site 0049) — Tempe

California

  • Chemidox Clinical Trials ( Site 0008) — Lancaster
  • Clinical Trials Research ( Site 0036) — Sacramento

Illinois

  • Trialmed ( Site 0026) — Chicago
  • Great Lakes Clinical Trials - Ravenswood ( Site 0018) — Chicago

Kansas

  • Alliance for Multispecialty Research, LLC ( Site 0048) — Newton
  • Cotton O'Neil Clinical Research Center ( Site 0006) — Topeka

Colorado

  • Legacy Clinical Trials ( Site 0044) — Colorado Springs

Indiana

  • Midwest Institute For Clinical Research ( Site 0033) — Indianapolis

Trial Details

FieldValue
Enrollment Target 975 participants
Start Date 2025-11-11
Est. Completion 2027-03-01
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07216482

The ClinicalTrials.gov registry entry for NCT07216482 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 975 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hyperlipidemia appearing as the primary indexed condition, and to 4 interventions — of which Rosuvastatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07216482 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07216482 about?

NCT07216482 is a clinical study titled "A Clinical Study of Enlicitide in Participants With High Cholesterol (MK-0616-037)". Researchers designed a study medicine called enlicitide to lower low-density lipoprotein cholesterol (LDL-C). In this study, researchers want to learn about giving enlicitide with another medicine called rosuvastatin. Rosuvastatin is a standard (usual) treatment to lower LDL-C. The goal of this stu...

What is the current status of trial NCT07216482?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 975 participants. The study started on 2025-11-11. Estimated completion is 2027-03-01.

What conditions does trial NCT07216482 study?

This clinical trial studies the following conditions: Hyperlipidemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07216482?

The interventions under investigation include: Rosuvastatin (DRUG), Enlicitide (DRUG), Placebo for Enlicitide (DRUG), Placebo for Rosuvastatin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07216482?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07216482 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial