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NCT02011789 · ClinicalTrials.gov registry record · NA
Metabolism And Health Effects Of Citrus Limonoids in Hypercholesterolemic Humans
A NA study of Hypercholesterolemia, sponsored by USDA, Western Human Nutrition Research Center.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT02011789: Completed NA study of Hypercholesterolemia, sponsored by USDA, Western Human Nutrition Research Center.
NCT02011789 is a NA study of Hypercholesterolemia that has completed, run by USDA, Western Human Nutrition Research Center. The registered enrollment target is 10 participants, below the 817-participant average among 62 other Hypercholesterolemia trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02011789, a NA study of Hypercholesterolemia, has completed, sponsored by USDA, Western Human Nutrition Research Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Limonoids are compounds found in citrus juices, seeds and peel. Some research shows that they reduce blood cholesterol and also reduce the incidence of several forms of cancer. Although these compounds are part of the natural human diet, the dose required to provide health benefits and the risks associated with the intake of high doses by humans have not been studied. This study will examine metabolism, safety, lipid-lowering and anti-inflammatory effects of limonoids. The dose of limonoids in this study is equivalent to that found in six 8 oz glasses of orange juice per day. The investigators hypothesize that limonin glucoside supplementation will reduce total cholesterol, LDL cholesterol, ratio of LDL and HDL cholesterol, number of LDL particles, and serum markers of inflammation.
Primary Outcome
Plasma cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride (TG), and remnant chylomicron particle concentrations will be determined. Lipid particle sizing will be performed by using nuclear magnetic resonance (NMR) technology. Plasma concentrations of apoproteins A1, B, C-III, and E will be measured.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Placebo beverage
- DIETARY_SUPPLEMENT Citrus Limonoid Beverage
Study Locations (1)
California
- USDA Western Human Nutrition Research Center - Davis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2007-04 |
| Est. Completion | 2010-07 |
| Phase | NA |
What the finished NCT02011789 record still lists
NCT02011789 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 817-participant average among 62 other Hypercholesterolemia trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Hypercholesterolemia appearing as the primary indexed condition, and to 2 interventions - of which Placebo beverage is the first listed.
NCT02011789 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT02011789 about?
NCT02011789 is a clinical study titled "Metabolism And Health Effects Of Citrus Limonoids in Hypercholesterolemic Humans". Limonoids are compounds found in citrus juices, seeds and peel. Some research shows that they reduce blood cholesterol and also reduce the incidence of several forms of cancer. Although these compounds are part of the natural human diet, the dose required to provide health benefits and the risks ass...
What is the current status of trial NCT02011789?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2007-04. Estimated completion is 2010-07.
What conditions does trial NCT02011789 study?
This clinical trial studies the following conditions: Hypercholesterolemia.
What interventions are being tested in trial NCT02011789?
The interventions under investigation include: Placebo beverage (DIETARY_SUPPLEMENT), Citrus Limonoid Beverage (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02011789?
This trial is sponsored by USDA, Western Human Nutrition Research Center, which has 47 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02011789 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02011789's enrollment target sits among peer trials
10 62nd of 62 the lowest of 62 other Hypercholesterolemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypercholesterolemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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