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ClinicalTrials.gov 18 recruiting now official registry

Huntington Disease clinical trials

18 of 36 indexed Huntington Disease trials are currently recruiting.

36 US clinical trials · 18 currently recruiting

Huntington Disease is the subject of 36 registered US clinical trials on ClinicalTrials.gov, 18 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 9 in Phase 1-2 (earlier-stage). The most active sponsor is Hoffmann-La Roche, running 3 of these trials.

The research picture

Huntington Disease has 36 registered US clinical trials, 18 of them open to new participants right now, about 50% of the total.

18
recruiting participants now
50%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
3
top sponsor: Hoffmann-La Roche
Phase 13Phase 26Phase 33

Active & Recent Trials

36 total, page 1 of 1

RECRUITING 10,000 participants

NYSCF Scientific Discovery Biobank

New York Stem Cell Foundation Research Institute

NCT06203106

RECRUITING 2,000 participants

Retinal Imaging in Neurodegenerative Disease

Duke University

NCT03233646

RECRUITING NA 1,800 participants

Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers

University of Washington

NCT05596760

RECRUITING 1,000 participants

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

xCures

NCT06539169

RECRUITING Phase 3 770 participants

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

Novartis Pharmaceuticals

NCT07326709

RECRUITING 600 participants

Longitudinal Endpoint Assessment of Disease Burden in HD

Huntington Study Group

NCT06475898

RECRUITING 600 participants

Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

Hoffmann-La Roche

NCT06667414

RECRUITING 200 participants

Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping

Stanford University

NCT06941662

RECRUITING NA 136 participants

Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)

University of Virginia

NCT07213648

RECRUITING 120 participants

Gait Analysis in Neurological Disease

Beth Israel Deaconess Medical Center

NCT02994719

RECRUITING 100 participants

Extracellular Vesicles for HD

University of Central Florida

NCT06082713

RECRUITING 100 participants

Digital Measures for Clinical Trial Endpoints in Huntington's Disease

University of Rochester

NCT07010705

RECRUITING 76 participants

Cognitive Assessment Tools for Huntington's Disease.

Ohio State University

NCT06546488

RECRUITING Phase 1 53 participants

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

Hoffmann-La Roche

NCT06826612

RECRUITING 36 participants

Gut Microbiomes in HD

University of Central Florida

NCT06448546

RECRUITING NA 16 participants

Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

The University of Texas Health Science Center at San Antonio

NCT06843252

RECRUITING NA 10 participants

Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

The University of Texas Health Science Center, Houston

NCT05326451

RECRUITING 5 participants

Prospective Single-Timepoint Huntington's Disease Biospecimen Collection Study

Sanguine Biosciences

NCT05773196

ACTIVE NOT RECRUITING 1,700 participants

Neurobiological Predictors of Huntington's Disease (PREDICT-HD)

Jordan Schultz

NCT00051324

ACTIVE NOT RECRUITING Phase 2 301 participants

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

Hoffmann-La Roche

NCT05686551

ACTIVE NOT RECRUITING Phase 2 30 participants

Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease

Vanderbilt University Medical Center

NCT04713982

COMPLETED 1,001 participants

Prospective Huntington At Risk Observational Study

Huntington Study Group

NCT00052143

COMPLETED Phase 3 403 participants

A Safety and Efficacy Study of Dimebon in Patients With Huntington Disease

Medivation

NCT00920946

COMPLETED Phase 3 300 participants

TREND-HD - A Trial of Ethyl-EPA (Miraxion™) in Treating Mild to Moderate Huntington's Disease

Amarin Neuroscience

NCT00146211

COMPLETED 258 participants

Preparing for Prevention of Huntington's Disease (PREVENT-HD)

University of Wisconsin, Madison

NCT04818060

COMPLETED Phase 2 227 participants

A Study of Pridopidine (ACR16) for the Treatment of Participants With Huntington's Disease

Teva Branded Pharmaceutical Products R&D

NCT00724048

COMPLETED Phase 2 109 participants

Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease

Prana Biotechnology Limited

NCT01590888

COMPLETED 85 participants

Genetic Risk: Whether, When, and How to Tell Adolescents

Johns Hopkins University

NCT03421327

COMPLETED Phase 2 64 participants

Creatine Safety and Tolerability in Premanifest HD: PRECREST

Massachusetts General Hospital

NCT00592995

COMPLETED 27 participants

Mitochondrial Biomarkers in Huntington's Disease

University Hospitals Cleveland Medical Center

NCT04515550

COMPLETED NA 22 participants

Time-Restricted Eating in Huntington's Disease: A Clinical Pilot Study

Oregon Health and Science University

NCT06490367

COMPLETED NA 20 participants

Move to Improve: Telehealth Exercise to Music for HD

Ohio State University

NCT05270681

COMPLETED Phase 2 20 participants

Atomoxetine and Huntington's Disease

University of Iowa

NCT00368849

COMPLETED Phase 1 20 participants

A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine)

Pfizer

NCT00988624

COMPLETED NA 15 participants

Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study

The University of Texas Health Science Center, Houston

NCT04421339

COMPLETED Phase 1 14 participants

A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan

Pfizer

NCT00788047

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Huntington Disease Trial Landscape

36 indexed Huntington Disease studies · 18 recruiting (50%).

Phase mix: 3 late (III/IV) vs 9 early (I/II).

Top sponsor: Hoffmann-La Roche (3 trials), 9 others listed. 36 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Huntington Disease?

PlainTrial tracks 36 US clinical trials for Huntington Disease, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Huntington Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.