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NCT04818060 · ClinicalTrials.gov registry record
Preparing for Prevention of Huntington's Disease (PREVENT-HD)
A clinical trial of Huntington Disease, sponsored by University of Wisconsin, Madison.
- Completed
- Registry status
- 258
- Enrollment target
- 1
- Study location
NCT04818060: Completed study of Huntington Disease, sponsored by University of Wisconsin, Madison.
NCT04818060 is a study of Huntington Disease that has completed, run by University of Wisconsin, Madison. The registered enrollment target is 258 participants, below the 628-participant average among 35 other Huntington Disease trials with a reported enrollment target (59% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04818060, a study of Huntington Disease, has completed, sponsored by University of Wisconsin, Madison.
- COMPLETED
- Registry status
- 258 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a prospective investigation which aims to address key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD). The project will provide necessary psychometric data for clinical outcome assessments (COAs) and biomarkers (BMs) in the cerebral spinal fluid (CSF) to address questions of central importance to the success of these measures for premanifest clinical trials. Of the 258 participants: 52 will be low risk of motor diagnosis, 102 high risk of motor diagnosis, 52 with diagnosed HD (stages I or II), and 52 healthy controls. Participants can expect to be in the study for up to 2 years.
Primary Outcome
UHDRS Motor Diagnosis of HD Diagnostic Confidence Level is a clinical rating of how confident the movement disorder specialist is that the person has manifest HD with over 99% confidence; scale is 0-4 where 0 is 'normal' and 4 is the highest motor dysfunction.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST MRI Scan
- OTHER Clinical Assessments
- DIAGNOSTIC_TEST Lumber Puncture (LP)
Study Locations (1)
Wisconsin
- University of Wisconsin - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 258 participants |
| Start Date | 2021-09-13 |
| Est. Completion | 2025-01-31 |
What the finished NCT04818060 record still lists
NCT04818060 is an observational study that tracks outcomes without assigning an intervention. The registered 258 participants enrollment target is mid-sized for trials with a published cap, below the 628-participant average among 35 other Huntington Disease trials with a reported enrollment target (59% lower).
The record links to 1 condition, with Huntington Disease appearing as the primary indexed condition, and to 3 interventions - of which MRI Scan is the first listed.
NCT04818060 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT04818060 about?
NCT04818060 is a clinical study titled "Preparing for Prevention of Huntington's Disease (PREVENT-HD)". This is a prospective investigation which aims to address key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD). The project will provide necessary psychometric data for clinical outcome assessments (COAs) and biomarkers (BMs) in the cerebral spinal fluid ...
What is the current status of trial NCT04818060?
This trial is currently completed. The enrollment target is 258 participants. The study started on 2021-09-13. Estimated completion is 2025-01-31.
What conditions does trial NCT04818060 study?
This clinical trial studies the following conditions: Huntington Disease.
What interventions are being tested in trial NCT04818060?
The interventions under investigation include: MRI Scan (DIAGNOSTIC_TEST), Clinical Assessments (OTHER), Lumber Puncture (LP) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04818060?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04818060 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Huntington Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04818060's enrollment target sits among peer trials
258 13th of 35 higher than 23 of 35 other Huntington Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Huntington Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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