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NCT06448546 · ClinicalTrials.gov registry record
Gut Microbiomes in HD
A clinical trial of Huntington Disease, sponsored by University of Central Florida.
- Recruiting
- Registry status
- 36
- Enrollment target
- 1
- Study location
NCT06448546: Recruiting study of Huntington Disease, sponsored by University of Central Florida.
NCT06448546 is a study of Huntington Disease that is actively recruiting participants, run by University of Central Florida. The registered enrollment target is 36 participants, below the 634-participant average among 35 other Huntington Disease trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06448546, a study of Huntington Disease, is actively recruiting participants, sponsored by University of Central Florida.
- RECRUITING
- Registry status
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to find out if there is a connection between the naturally occurring bacteria in our bodies and the progression of Huntington disease. The investigators are trying to determine if patients who are diagnosed with adult-onset HD and who exhibit a rapid rate of disease progression have unique populations of bacteria in their gut as compared to patients with slower progression.
Primary Outcome
Metagenomic analysis via 16S ribosomal RNA (rRNA) gene sequencing will be performed on HD and control stool samples to identify HD-associated changes in microbe abundance at the genus level.
Conditions Studied
Study Locations (1)
Florida
- University of Central Florida - Orlando
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2025-06 |
| Est. Completion | 2029-06 |
What NCT06448546 shows while recruiting
NCT06448546 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 634-participant average among 35 other Huntington Disease trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Huntington Disease appearing as the primary indexed condition, and to 0 interventions.
NCT06448546 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06448546 about?
NCT06448546 is a clinical study titled "Gut Microbiomes in HD". The purpose of this study is to find out if there is a connection between the naturally occurring bacteria in our bodies and the progression of Huntington disease. The investigators are trying to determine if patients who are diagnosed with adult-onset HD and who exhibit a rapid rate of disease prog...
What is the current status of trial NCT06448546?
This trial is currently recruiting. The enrollment target is 36 participants. The study started on 2025-06. Estimated completion is 2029-06.
What conditions does trial NCT06448546 study?
This clinical trial studies the following conditions: Huntington Disease.
Who is sponsoring clinical trial NCT06448546?
This trial is sponsored by University of Central Florida, which has 91 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06448546 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Huntington Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06448546's enrollment target sits among peer trials
36 25th of 35 higher than 11 of 35 other Huntington Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Huntington Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
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