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HIV-1-infection clinical trials
24 of 72 indexed HIV-1-infection trials are currently recruiting.
72 US clinical trials · 24 currently recruiting
HIV-1-infection is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 24 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most active sponsor is Gilead Sciences, running 20 of these trials.
The research picture
HIV-1-infection has 72 registered US clinical trials, 24 of them open to new participants right now, about 33% of the total.
- 24
- recruiting participants now
- 33%
- of trials open to enrollment
- 15
- in Phase 3–4 (later-stage)
- 20
- top sponsor: Gilead Sciences
Active & Recent Trials
72 total, page 2 of 2
Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Thomas Jefferson University
NCT03646370
Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging With HIV
University of Alabama at Birmingham
NCT05314088
A Mobile Intervention to Promote Cessation in HIV-infected Smokers
Montefiore Medical Center
NCT02432482
Atorvastatin on Biomarkers of Inflammation, Coagulopathy, Angiogenesis & T-cells
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT01351025
Evaluating Pharmacokinetic Interactions With Vaginal Ring Contraceptives and ART
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT01903031
Acute Neural and Immune Effects of Alcohol in People Living With HIV Infection
Brown University
NCT04050735
Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT01969058
Study to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Fixed Dose Combination (FDC) in Virologically-Suppressed HIV-1 Infected Adults Harboring the Archived Isolated NRTI Resistance Mutation M184V/M184I
Gilead Sciences
NCT02616029
Biomarkers to Predict Time to Plasma HIV RNA Rebound
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT03001128
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of E/C/F/TAF Fixed Dose Combination (FDC) in HIV-1 Infected Adults on Chronic Hemodialysis
Gilead Sciences
NCT02600819
10E8.4/iMab Bispecific Antibody in HIV-uninfected and HIV-infected Adults
David Ho
NCT03875209
Study to Evaluate Safety, Pharmacokinetics, and Antiviral Activity of Lenacapavir Administered Subcutaneously in Human Immunodeficiency Virus (HIV) -1 Infected Adults
Gilead Sciences
NCT03739866
Study of Novel Antiretrovirals in Participants With HIV-1
Gilead Sciences
NCT05585307
Study of B/F/TAF in Participants Switching From CAB + RPV to B/F/TAF for HIV-1 Infection (EMPOWER)
Gilead Sciences
NCT06104306
Assessing Short and Long Term Compliance With Caloric Intake in HIV Positive Women Taking Complera
Prema Menezes, PhD, PA-C
NCT01701895
Safety and Efficacy of Sirolimus for HIV Reservoir Reduction in Individuals on Suppressive Antiretroviral Therapy (ART)
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT02440789
The Effect of Vorinostat on HIV RNA Expression in the Resting CD4+ T Cells of HIV+ Pts on Stable ART
University of North Carolina, Chapel Hill
NCT01319383
Maraviroc Plus Darunavir/Ritonavir for Treatment-Naïve Patients Infected With R5-tropic HIV-1
Northwestern University
NCT00993148
Mental Ability Challenge Study in Adults With and Without HIV
Vanderbilt University Medical Center
NCT03244488
A Study of the Safety and Antiretroviral Activity of 3BNC117
Rockefeller University
NCT02588586
Islatravir and Methadone Pharmacokinetics (MK-8591-029)
Merck Sharp & Dohme
NCT04568603
Safety of FMT Using Oral Encapsulated PRIM-DJ2727 in HIV
The University of Texas Health Science Center, Houston
NCT03329560
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 21 |
| Phase 3 | 12 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV-1-infection Trial Landscape
72 indexed HIV-1-infection studies · 24 recruiting (33%).
Phase mix: 15 late (III/IV) vs 40 early (I/II).
Top sponsor: Gilead Sciences (20 trials), 9 others listed. 22 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV-1-infection?
PlainTrial tracks 72 US clinical trials for HIV-1-infection, of which 24 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV-1-infection?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.