Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 4

Study of B/F/TAF in Participants Switching From CAB + RPV to B/F/TAF for HIV-1 Infection (EMPOWER)

NCT06104306 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical study is to learn how safe it is to switch to an oral therapy of Bictegravir/Emtricitabine/Tenofovir (B/F/TAF) from Cabotegravir + Rilpivirine (CAB+RPV) in participants living with virologically suppressed human immunodeficiency virus type 1 (HIV-1), meaning participants with HIV RNA levels below detectable levels. The primary objective of this study is to assess the safety of switching to B/F/TAF in virologically suppressed participants unable/unwilling to continue on CAB+RPV intramuscular (IM) injections or wishing to switch to oral therapy through Week 12.

Conditions Studied

Interventions

  • DRUG B/F/TAF

Study Locations (18)

Other

  • Hamilton Health Sciences-SIS Clinic — Hamilton
  • St. Michael's Hospital — Toronto
  • University Health Network - Toronto General Hospital — Toronto
  • CHU Bordeaux - Hopital Saint-Andre — Bordeaux
  • APHM - Hospital Sainte Marguerite — Marseille
  • CHR Orleans — Orléans
  • Centre Hospitalier Annecy Genevois — Pringy
  • HU de Strasbourg - Nouvel Hopital Civil — Strasbourg

California

  • Franco Felizarta, MD — Bakersfield
  • BIOS Clinical Research — Palm Springs
  • UC San Diego AntiViral Research Center (AVRC) — San Diego

Florida

  • Midway Immunology and Research Center — Ft. Pierce
  • Bliss Health — Orlando

Indiana

  • Indiana University Infectious Diseases Research — Indianapolis

Massachusetts

  • Boston Medical Center — Boston

Nevada

  • Las Vegas Research Center — Las Vegas

New Jersey

  • Saint Michael's Medical Center — Newark

Washington

  • MultiCare Rockwood Main Clinic — Spokane

Trial Details

FieldValue
Enrollment Target 33 participants
Start Date 2023-12-13
Est. Completion 2025-04-23
Phase Phase 4

Sponsor

Gilead Sciences

190 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06104306

The ClinicalTrials.gov registry entry for NCT06104306 describes a study currently listed as completed. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 33 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gilead Sciences, which has 190 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with HIV-1-infection appearing as the primary indexed condition, and to 1 intervention — of which B/F/TAF is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06104306 reports 18 study locations spanning 8 distinct geographic areas — top geographies include Other, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06104306 about?

NCT06104306 is a clinical study titled "Study of B/F/TAF in Participants Switching From CAB + RPV to B/F/TAF for HIV-1 Infection (EMPOWER)". The goal of this clinical study is to learn how safe it is to switch to an oral therapy of Bictegravir/Emtricitabine/Tenofovir (B/F/TAF) from Cabotegravir + Rilpivirine (CAB+RPV) in participants living with virologically suppressed human immunodeficiency virus type 1 (HIV-1), meaning participants wi...

What is the current status of trial NCT06104306?

This trial is currently completed. It is a Phase 4 study. The enrollment target is 33 participants. The study started on 2023-12-13. Estimated completion is 2025-04-23.

What conditions does trial NCT06104306 study?

This clinical trial studies the following conditions: HIV-1-infection. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06104306?

The interventions under investigation include: B/F/TAF (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06104306?

This trial is sponsored by Gilead Sciences, which has 190 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06104306 being conducted?

This trial has 18 study locations across California, Florida, Indiana, Massachusetts, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial