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ClinicalTrials.gov 1 recruiting now official registry

Hepatitis C, Chronic clinical trials

1 of 27 indexed Hepatitis C, Chronic trials are currently recruiting.

27 US clinical trials · 1 currently recruiting

Hepatitis C, Chronic is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Hoffmann-La Roche, running 9 of these trials.

The research picture

Hepatitis C, Chronic has 27 registered US clinical trials, 1 of them open to new participants right now, about 4% of the total.

1
recruiting participants now
4%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
9
top sponsor: Hoffmann-La Roche
Phase 14Phase 211Phase 32Phase 46

Active & Recent Trials

27 total, page 1 of 1

RECRUITING Phase 4 100 participants

Sofosbuvir/Velpatasvir Treatment of Chronic Hepatitis C During Pregnancy

Catherine Anne Chappell

NCT05140941

ACTIVE NOT RECRUITING Phase 4 121 participants

People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03520660

COMPLETED Phase 4 4,766 participants

A Study on the Correlation Between Interleukin 28B Genotypes With Clinical and Demographic Characteristics in Treatment-Naïve and Treatment-Experienced Patients With Chronic Hepatitis C

Hoffmann-La Roche

NCT01675427

COMPLETED Phase 3 663 participants

A Safety and Effectiveness Study of Telaprevir in Chronic, Genotype 1, Hepatitis C Patients That Failed Previous Standard Treatment

Tibotec BVBA

NCT00703118

COMPLETED 570 participants

A Gilead Sequence Registry of Subjects Who Did Not Achieve Sustained Virologic Response

Gilead Sciences

NCT01457768

COMPLETED Phase 2 421 participants

A Study of Danoprevir Boosted With Low Dose Ritonavir in Combination With Pegasys and Copegus in Treatment-Naive Patients With Chronic Hepatitis C Virus Infection

Hoffmann-La Roche

NCT01220947

COMPLETED Phase 2 413 participants

A Study of RO5024048 in Combination With Pegasys and Copegus in Treatment-Naive Patients With Chronic Hepatitis C, Genotype 1 or 4

Hoffmann-La Roche

NCT00869661

COMPLETED Phase 2 351 participants

GS-5885 Alone or in Combination With GS-9451 With Peginterferon Alfa 2a and Ribavirin in Treatment Chronic Genotype 1 Hepatitis C Virus

Gilead Sciences

NCT01356160

COMPLETED Phase 2 286 participants

Dose Ranging of GSK2336805 in Combination Therapy

GlaxoSmithKline

NCT01648140

COMPLETED Phase 2 275 participants

A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV

Atea Pharmaceuticals

NCT05904470

COMPLETED Phase 2 239 participants

Safety Study of Regimens of Sofosbuvir, GS-0938, and Ribavirin in Patients With Chronic Hepatitis C Infection

Gilead Sciences

NCT01435044

COMPLETED Phase 3 235 participants

A Study of Combination Therapy With PEGASYS (Pegylated Interferon Alfa-2a (40KD)) and Copegus (Ribavirin) in Patients With Chronic Hepatitis C Genotype 2 or 3 Who Do Not Achieve a Rapid Viral Response

Hoffmann-La Roche

NCT00623428

COMPLETED Phase 2 204 participants

A Caspase Inhibitor in Chronic Hepatitis C (HCV) Patients

Conatus Pharmaceuticals

NCT00088140

COMPLETED Phase 4 188 participants

A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With COPEGUS (Ribavirin) in Interferon-Naive Patients With Chronic Hepatitis C Infection (CHC).

Hoffmann-La Roche

NCT00077649

COMPLETED Phase 4 115 participants

PHOENIX Study - A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) and COPEGUS (Ribavirin) Administered After Liver Transplantation for Hepatitis C.

Hoffmann-La Roche

NCT00087633

COMPLETED Phase 2 110 participants

ANNAPURNA: A Study of The Combination of RO5466731, RO5190591, Ritonavir and Copegus (Ribavirin) With or Without RO5024048 in Patients With Chronic Hepatitis C Who Are Either Treatment-Naïve or Have Previously Experienced a Null Response to Interferon-Based Treatment

Hoffmann-La Roche

NCT01628094

COMPLETED 100 participants

Anticipated and Perceived Benefits Following Hepatitis C Treatment

University of North Carolina, Chapel Hill

NCT03000023

COMPLETED Phase 1 96 participants

Safety, Antiviral Activity and PK of MRD of BI 201335 in Chronic Hepatitis C Patients Both Treatment Naive and -Experienced

Boehringer Ingelheim

NCT00793793

COMPLETED Phase 1 81 participants

Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis C

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00718172

COMPLETED NA 80 participants

Linkage to Care for Persons with Hep C Infection

Carilion Clinic

NCT05397067

COMPLETED Phase 2 75 participants

SB497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adults With Thrombocytopenia Due To Hepatitis C

GlaxoSmithKline

NCT00110799

COMPLETED Phase 4 63 participants

A Study of Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) Combination Therapy in Participants With Chronic Hepatitis C (CHC) and Various Degrees of Renal Impairment

Hoffmann-La Roche

NCT02864199

COMPLETED Phase 1 56 participants

Study of PEG-rIL-29 (or PEG-IFN Lambda) in Subjects With Chronic Hepatitis C Virus Infection

ZymoGenetics

NCT00565539

COMPLETED NA 48 participants

Intra-Individual Reproducibility of the Non-Invasive Assessment of the Portal Circulation

HepQuant

NCT01579162

COMPLETED Phase 1 45 participants

IdB 1016 Treatment for Hepatitis C Disease

National Center for Complementary and Integrative Health (NCCIH)

NCT00055445

COMPLETED Phase 2 43 participants

A Study of Ritonavir-Boosted Danoprevir and RO5024048 in Different Combinations in Null Responder or Treatment-Naïve Patients With Chronic Hepatitis C and Compensated Cirrhosis

Hoffmann-La Roche

NCT01483742

COMPLETED Phase 2 35 participants

New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01888900

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 11
Phase 3 2
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatitis C, Chronic Trial Landscape

27 indexed Hepatitis C, Chronic studies · 1 recruiting (4%).

Phase mix: 8 late (III/IV) vs 15 early (I/II).

Top sponsor: Hoffmann-La Roche (9 trials), 9 others listed. 27 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatitis C, Chronic?

PlainTrial tracks 27 US clinical trials for Hepatitis C, Chronic, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatitis C, Chronic?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.