Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02772068 · ClinicalTrials.gov registry record · Early Phase 1
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a
A Early Phase 1 study of Heart Failure, Congestive, sponsored by Benjamin Levine.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT02772068: Completed Early Phase 1 study of Heart Failure, Congestive, sponsored by Benjamin Levine.
NCT02772068 is a Early Phase 1 study of Heart Failure, Congestive that has completed, run by Benjamin Levine. The registered enrollment target is 26 participants, below the 674-participant average among 39 other Heart Failure, Congestive trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02772068, a Early Phase 1 study of Heart Failure, Congestive, has completed, sponsored by Benjamin Levine.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
Heart failure with preserved ejection fraction or HFpEF, represents nearly 50% of all heart failure cases and is particularly common in the elderly. The disease has no current treatment options. Symptoms typically occur during exertion or exercise and is likely the result of increased cardiac and pulmonary congestion as a result of impaired diastolic function. Istaroxime is a novel activator of SERCA2a, an important regulator of calcium uptake within the myocyte. We will test the hypothesis that Istaroxime will improve diastolic function during exercise in HFpEF patients which in turn will reduce cardiac and pulmonary congestion.
Primary Outcome
Change in cardiac filling pressures (pulmonary capillary wedge pressure) during exercise with Istaroxime
Conditions Studied
Interventions
- OTHER Exercise
- DRUG Istaroxime
Study Locations (1)
Texas
- The Institute for Exercise and Environmental Medicine - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2015-09-15 |
| Est. Completion | 2018-12-01 |
| Phase | Early Phase 1 |
What the finished NCT02772068 record still lists
NCT02772068 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 674-participant average among 39 other Heart Failure, Congestive trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Heart Failure, Congestive appearing as the primary indexed condition, and to 2 interventions - of which Exercise is the first listed.
NCT02772068 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT02772068 about?
NCT02772068 is a clinical study titled "Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a". Heart failure with preserved ejection fraction or HFpEF, represents nearly 50% of all heart failure cases and is particularly common in the elderly. The disease has no current treatment options. Symptoms typically occur during exertion or exercise and is likely the result of increased cardiac and pu...
What is the current status of trial NCT02772068?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 26 participants. The study started on 2015-09-15. Estimated completion is 2018-12-01.
What conditions does trial NCT02772068 study?
This clinical trial studies the following conditions: Heart Failure, Congestive.
What interventions are being tested in trial NCT02772068?
The interventions under investigation include: Exercise (OTHER), Istaroxime (DRUG).
Who is sponsoring clinical trial NCT02772068?
This trial is sponsored by Benjamin Levine, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02772068 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure, Congestive
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02772068's enrollment target sits among peer trials
26 36th of 39 higher than 4 of 39 other Heart Failure, Congestive trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure, Congestive trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Family Intervention for Improving Self-Care of Patients With Heart Failure
COMPLETED · Early Phase 1
-
Nicotinamide Riboside in LVAD Recipients
COMPLETED · Early Phase 1
-
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
RECRUITING · NA
-
Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention
RECRUITING
-
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
RECRUITING
-
Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02646475 · 26 participants · Phase 1
Metabolic Effects of Angiotensin-(1-7)
- NCT03603223 · 26 participants · Phase 2
Pembrolizumab in Treating Participants With Leukoplakia
- NCT04063592 · 26 participants · NA
AMI Construction in Lower Extremity Residual Limbs
- NCT04906460 · 26 participants · Phase 1
Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI