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NCT00181259 · ClinicalTrials.gov registry record
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
A clinical trial of Heart Failure, Congestive, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- 500
- Enrollment target
- 1
- Study location
NCT00181259: Recruiting study of Heart Failure, Congestive, sponsored by Johns Hopkins University.
NCT00181259 is a study of Heart Failure, Congestive that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 500 participants, below the 662-participant average among 39 other Heart Failure, Congestive trials with a reported enrollment target (24% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00181259, a study of Heart Failure, Congestive, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.
Primary Outcome
Can non-invasive magnetic resonance imaging and spectroscopy techniques be developed, validated, and implemented on clinical MR scanners in order to address the questions of a.) the extent to which myocardial high-energy phosphate (HEP), creatine (Cr), or sodium concentrations change in response to and after transient ischemia or chronic ischemic injury, b.) the extent to which myocardial high-energy phosphates, creatine, or sodium concentrations as well as HEP flux are altered in cardiomyopathi
Conditions Studied
Study Locations (1)
Maryland
- Johns Hopkins Medical Institutions - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 1988-01 |
| Est. Completion | 2028-08 |
What NCT00181259 shows while recruiting
NCT00181259 is an observational study that tracks outcomes without assigning an intervention. The registered 500 participants enrollment target is mid-sized for trials with a published cap, below the 662-participant average among 39 other Heart Failure, Congestive trials with a reported enrollment target (24% lower).
The record links to 1 condition, with Heart Failure, Congestive appearing as the primary indexed condition, and to 0 interventions.
NCT00181259 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00181259 about?
NCT00181259 is a clinical study titled "Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism". The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One ...
What is the current status of trial NCT00181259?
This trial is currently recruiting. The enrollment target is 500 participants. The study started on 1988-01. Estimated completion is 2028-08.
What conditions does trial NCT00181259 study?
This clinical trial studies the following conditions: Heart Failure, Congestive.
Who is sponsoring clinical trial NCT00181259?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00181259 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure, Congestive
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00181259's enrollment target sits among peer trials
500 12th of 39 higher than 28 of 39 other Heart Failure, Congestive trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure, Congestive trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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