Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Heart Disease: early-phase trial registry
12 of 34 indexed Heart Disease trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #451 of 28,707 conditions by registered trial count.
34 US clinical trials · 12 currently recruiting · #451 of 28,707 conditions by registered trial count
Heart Disease: 34 US clinical trials tracked, 12 recruiting.
Heart Disease is the subject of 34 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Environmental Health Sciences (NIEHS), running 2 of these trials.
Enrollment posture brief
Registry condition heart-disease
OPEN 12 | RECR 35% | LATE 3 | EARLY 6 | RANK #451 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Arrhythmia (35% recruiting · 17 trials)
Heart Disease lists 12 open slots (35% of 34 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Disease is recruiting below its size-band peers.
12 of 34 indexed trials (35.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Disease trials is spread across many organizations.
National Institute of Environmental Health Sciences (NIEHS) accounts for 2 of 34 trials (5.9%). 30 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Disease enrolment sits around 290 participants.
Median target enrolment is 290 among the 32 trials that report a genuine target (sentinel values excluded). 7 of those (21.9%) plan for fewer than 100 participants.
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Heart Disease splits between interventional and observational designs.
19 interventional and 15 observational studies make up this index (55.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
34 total, page 1 of 1
Personalized Environment and Genes Study
National Institute of Environmental Health Sciences (NIEHS)
NCT00341237
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
Texas A&M University
NCT06726590
Cooperative Assessment of Late Effects for SCD Curative Therapies
Vanderbilt University Medical Center
NCT05153967
Heart Disease of the Small Arteries in Women and Men
Cedars-Sinai Medical Center
NCT00573027
Diet and Active Lifestyle - Yuuyaraq (The Yup'ik Way of Life)
Oregon Health and Science University
NCT06629610
Using CTA Measures to Define Cardiac Risk In NFL Alumni
HeartFlow
NCT06831409
Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions
San Diego State University
NCT06596902
Focused Orticumab Research for Treating Inflammation in Coronary Arteries
Abcentra
NCT06927739
Dilated Cardiomyopathy Detection Using AI and Screening With Mobile Technology (DCM-DETECT)
Lancaster General Hospital
NCT06688396
Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation
Duke University
NCT07214350
Healthy Living Anson Study
University of North Carolina, Chapel Hill
NCT07126587
Studies of Neuregulin/ERBB Signaling in Human Heart
Douglas B. Sawyer
NCT02820233
Aspirin in Reducing Events in the Elderly-Extension (ASPREE-XT)
Anne Murray
NCT07224347
NYUCI-ES: Psychosocial Intervention to Improve Health Outcomes for Chinese and Korean ADRD Caregivers
New York University
NCT05461495
Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy
Johns Hopkins University
NCT02694094
Environmental Polymorphisms Registry Health and Exposures Survey
National Institute of Environmental Health Sciences (NIEHS)
NCT01688986
Cardiac Allograft Rejection Gene Expression Observational (CARGO) II STUDY
XDx
NCT00761787
The CREATE Wellness Study
Kaiser Permanente
NCT02302612
Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization
The University of Texas Health Science Center, Houston
NCT00178620
A Helping Hand Among Low-Income Patients
University of Southern California
NCT02147522
Family Genetics Health Education and Healthy Behaviors
National Human Genome Research Institute (NHGRI)
NCT01498276
The Estrogen Replacement and Atherosclerosis Trial ; Primary Outcome Measure is Mean Minimal Coronary Artery Diameter After Avg of 3.2 Yrs.
Wake Forest University Health Sciences
NCT03097120
A Comparison of Two Sedation Techniques in Children Undergoing Transthoracic Echocardiography (TTE)
Children's Hospital Medical Center, Cincinnati
NCT02250820
Communicating Smoking Risks Through Graphic Warning Labels
University of Pennsylvania
NCT01782053
Strong Hearts: Rural CVD Prevention
Cornell University
NCT02499731
Evaluation of the Safety and Biologic Effects of an Eicosapentaenoic (EPA)-Enriched Oil
Cardiovascular Research Associates
NCT00988585
Initial Experience With the AngioVac Venous Drainage Cannula
Angiodynamics
NCT02775565
Comparison Endotracheal Cardiac Output Monitor (ECOM) to a Standard Device in Measuring Heart Blood Volume
University of California, Los Angeles
NCT00883857
Beating the Blues for Your Heart
Indiana University
NCT01605552
NUTRITION MATTERS: A Food is Medicine Intervention for African-American Adults With Multiple Chronic Conditions
Winston Salem State University
NCT06933940
Sildenafil in Single Ventricle Patients
Duke University
NCT01169519
Pharmacokinetic Study of Dexmedetomidine After Intra-nasal Dosing in Children
Children's Hospital Medical Center, Cincinnati
NCT02836431
Screening for Inherited Heart Disease
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001746
Outpatient Evaluation of Patients With Known or Suspected Heart Disease
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001400
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 2 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Disease page
34 registered trials, 12 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 12 Heart Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Institute of Environmental Health Sciences (NIEHS) sponsors the most Heart Disease trials on record, review their full trial history before evaluating a specific study. See National Institute of Environmental Health Sciences (NIEHS)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Disease condition card totals 34 registered trials; most-linked intervention Nasal Placebo; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.