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NCT00341237 · ClinicalTrials.gov registry record
Personalized Environment and Genes Study
A clinical trial of Asthma and Diabetes, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Recruiting
- Registry status
- 25,000
- Enrollment target
- 1
- Study location
NCT00341237: Recruiting study of Asthma and Diabetes, sponsored by National Institute of Environmental Health Sciences (NIEHS).
NCT00341237 is a study of Asthma and Diabetes that is actively recruiting participants, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 25,000 participants, above the 1,497-participant average among 374 other Asthma trials with a reported enrollment target (1570% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00341237, a study of Asthma and Diabetes, is actively recruiting participants, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- RECRUITING
- Registry status
- 25,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Despite the overwhelming focus on genetic and genomic causes of human disease over the past two decades, it has been estimated that genetics is currently known to explain only 20% and 40% of the etiology of common disease. Thus, it is becoming increasingly apparent that human disease is a consequence of both genetic susceptibility and environmental exposures. Importantly, while individuals cannot change their genetic composition, we do have the ability both personally and as a society, to influence our environment, promoting health and decreasing the risk of disease. The Personalized Environment and Genes Study (PEGS) aims to determine how the environment and gene-environment interactions can inform our understanding of human health and disease. As science has evolved, so too has the science of this project. This evolution was reflected in a change in the title of this project from the Environmental Polymorphisms Registry (EPR) to the Personalized Environment and Genes Study (PEGS) to more accurately reflect the science that can be conducted. PEGS is a unique resource because of the depth of environmental phenotyping which includes extensive information from exposome surveys, as well as whole genome sequencing on a significant number of participants in the cohort. While it is small relative to genomic cohorts, none of these have the extensive environmental data that is present in PEGS. In addition, other cohorts with deep environmental data lack the depth of genomic data that is present in PEGS. Importantly, PEGS has already provided important analytic advances that are of great interest to and can be confirmed in larger cohorts such as All of Us. The Personalized Environment and Genes Study (PEGS) aims to provide a resource for environmental health translational research by examining gene-environment interactions in health and disease. PEGS is an extension of two previous efforts where it began as a pilot study, the Environmental Polymorphisms Study (EPS; IRB# 02E
Primary Outcome
Genetic changes and disease.
Conditions Studied
Study Locations (1)
North Carolina
- NIEHS Clinical Research Unit (CRU) - Research Triangle Park
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25,000 participants |
| Start Date | 2010-05-26 |
What NCT00341237 shows while recruiting
NCT00341237 is an observational study that tracks outcomes without assigning an intervention. Its 25,000 participants enrollment target places it among the larger protocols in the corpus, above the 1,497-participant average among 374 other Asthma trials with a reported enrollment target (1570% higher).
The record links to 3 conditions, with Asthma appearing as the primary indexed condition, and to 0 interventions.
NCT00341237 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT00341237 about?
NCT00341237 is a clinical study titled "Personalized Environment and Genes Study". Despite the overwhelming focus on genetic and genomic causes of human disease over the past two decades, it has been estimated that genetics is currently known to explain only 20% and 40% of the etiology of common disease. Thus, it is becoming increasingly apparent that human disease is a consequenc...
What is the current status of trial NCT00341237?
This trial is currently recruiting. The enrollment target is 25,000 participants. The study started on 2010-05-26.
What conditions does trial NCT00341237 study?
This clinical trial studies the following conditions: Asthma, Diabetes, Heart Disease.
Who is sponsoring clinical trial NCT00341237?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00341237 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00341237's enrollment target sits among peer trials
25,000 5th of 374 higher than 370 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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