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NCT02366065 · ClinicalTrials.gov registry record · Early Phase 1
Does Oral Acetaminophen Lower Intraocular Pressure?
A Early Phase 1 study of Glaucoma, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 11
- Enrollment target
- 1
- Study location
NCT02366065: Completed Early Phase 1 study of Glaucoma, sponsored by Johns Hopkins University.
NCT02366065 is a Early Phase 1 study of Glaucoma that has completed, run by Johns Hopkins University. The registered enrollment target is 11 participants, below the 911-participant average among 92 other Glaucoma trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02366065, a Early Phase 1 study of Glaucoma, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 11 participants
- Enrollment target
- 1
- Study location
Study Summary
\- Lowering intraocular pressure is the only proven treatment for glaucoma. Medications, almost always in the form of eye drops, are a mainstay for lowering intraocular pressure. Eye drops have the disadvantage of being difficult to administer and can have adverse effects on the surface of the eye and the surrounding tissues. Lowering intraocular pressure can be accomplished with oral carbonic anhydrase inhibitors, but the many systemic side effects of these agents relegates them to drugs of last resort. Therefore, an effective, well-tolerated, oral agent would be an important addition to the treatment of glaucoma. The hypothesis is that oral acetaminophen can lower intraocular pressure to a clinically significant degree in a dosing regimen that is both safe and convenient. The research is important because acetaminophen is inexpensive, available over-the-counter, and has a well known safety and side effect profile.
Primary Outcome
Eye pressure will be measured by using an IOP applanation tonometer seven days after the patient has stopped the medication.
Conditions Studied
Interventions
- DRUG Acetaminophen
Study Locations (1)
Maryland
- Johns Hopkins - The Wilmer Eye Institute - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2015-01 |
| Est. Completion | 2016-05 |
| Phase | Early Phase 1 |
What the finished NCT02366065 record still lists
NCT02366065 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 911-participant average among 92 other Glaucoma trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Glaucoma appearing as the primary indexed condition, and to 1 intervention - of which Acetaminophen is the first listed.
NCT02366065 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT02366065 about?
NCT02366065 is a clinical study titled "Does Oral Acetaminophen Lower Intraocular Pressure?". \- Lowering intraocular pressure is the only proven treatment for glaucoma. Medications, almost always in the form of eye drops, are a mainstay for lowering intraocular pressure. Eye drops have the disadvantage of being difficult to administer and can have adverse effects on the surface of the eye a...
What is the current status of trial NCT02366065?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 11 participants. The study started on 2015-01. Estimated completion is 2016-05.
What conditions does trial NCT02366065 study?
This clinical trial studies the following conditions: Glaucoma.
What interventions are being tested in trial NCT02366065?
The interventions under investigation include: Acetaminophen (DRUG).
Who is sponsoring clinical trial NCT02366065?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02366065 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glaucoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02366065's enrollment target sits among peer trials
11 90th of 92 higher than 2 of 92 other Glaucoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glaucoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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