Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

NCT06744920 · View on ClinicalTrials.gov ↗

Study Summary

A study to evaluate the efficacy, safety and tolerability of Remibrutinib versus placebo in adult patients with Generalized Myasthenia Gravis who are on stable, standard-of-care (SOC) treatment.

Interventions

  • OTHER Placebo
  • DRUG Remibrutinib (Blinded)
  • DRUG Remibrutinib (Open Label)

Study Locations (20)

Florida

  • SFM Clinical Research LLC — Boca Raton
  • Homestead Assoc In Research Inc — Homestead
  • AdventHealth — Orlando
  • Neurological Services of Orlando PA — Orlando

California

  • Fullerton Neuro and Headache Ctr — Fullerton
  • University Of Southern California — Los Angeles
  • Univ Cali Irvine ALS Neuromuscular — Orange

Arizona

  • Neuromuscular Research Center — Phoenix
  • Honor Health Research Institute — Scottsdale

Texas

  • Houston Methodist Hospital — Houston
  • UT Health Science Center — Houston

Maryland

  • Mid Atlantic Epilepsy and Sleep Ctr — Bethesda

Michigan

  • Michigan State University-Department of Neurology — East Lansing

New York

  • Dent Neurological Institute — Buffalo

Ohio

  • Univ of Cincinnati Medical Center — Cincinnati

Trial Details

FieldValue
Enrollment Target 180 participants
Start Date 2025-02-07
Est. Completion 2033-02-26
Phase Phase 3

Sponsor

Novartis Pharmaceuticals

792 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06744920

The ClinicalTrials.gov registry entry for NCT06744920 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Generalized Myasthenia Gravis appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06744920 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06744920 about?

NCT06744920 is a clinical study titled "A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis". A study to evaluate the efficacy, safety and tolerability of Remibrutinib versus placebo in adult patients with Generalized Myasthenia Gravis who are on stable, standard-of-care (SOC) treatment.

What is the current status of trial NCT06744920?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 180 participants. The study started on 2025-02-07. Estimated completion is 2033-02-26.

What conditions does trial NCT06744920 study?

This clinical trial studies the following conditions: Generalized Myasthenia Gravis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06744920?

The interventions under investigation include: Placebo (OTHER), Remibrutinib (Blinded) (DRUG), Remibrutinib (Open Label) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06744920?

This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06744920 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Maryland, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial