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RECRUITING Phase 2

KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis

NCT06193889 · View on ClinicalTrials.gov ↗

Study Summary

A Study of the Anti-CD 19 Chimeric Antigen Receptor T Cell Therapy for Patients with Myasthenia Gravis

Interventions

  • DRUG Standard lymphodepletion regimen
  • DRUG Standard of Care Treatment
  • BIOLOGICAL KYV-101

Study Locations (14)

Other

  • Hospital Israelita Albert Einstein — São Paulo
  • Charite- Universitätsklinikum Berlin — Berlin
  • Universitätsklinikum der Ruhr-Universität Bochum — Bochum
  • Universitätsklinikum Hamburg-Eppendorf — Hamburg
  • Medizinische Hochscule Hannover — Hanover
  • Friedrich-Schiller-Universität Jena — Jena
  • Universitätsklinik Magdeburg — Magdeburg

California

  • University of California, Irvine — Orange
  • Stanford University Medical Center — Palo Alto

Florida

  • University of Miami — Miami

Indiana

  • Indiana University Health — Indianapolis

Pennsylvania

  • Thomas Jefferson University Hospital — Philadelphia

Texas

  • Houston Methodist Hospital — Houston

Utah

  • Intermountain Medical Center — Murray

Trial Details

FieldValue
Enrollment Target 66 participants
Start Date 2024-08-28
Est. Completion 2028-09
Phase Phase 2

Sponsor

Kyverna Therapeutics

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06193889

The ClinicalTrials.gov registry entry for NCT06193889 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 66 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kyverna Therapeutics, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Myasthenia Gravis appearing as the primary indexed condition, and to 3 interventions — of which Standard lymphodepletion regimen is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06193889 reports 14 study locations spanning 7 distinct geographic areas — top geographies include Other, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06193889 about?

NCT06193889 is a clinical study titled "KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia Gravis". A Study of the Anti-CD 19 Chimeric Antigen Receptor T Cell Therapy for Patients with Myasthenia Gravis

What is the current status of trial NCT06193889?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 66 participants. The study started on 2024-08-28. Estimated completion is 2028-09.

What conditions does trial NCT06193889 study?

This clinical trial studies the following conditions: Myasthenia Gravis, Generalized Myasthenia Gravis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06193889?

The interventions under investigation include: Standard lymphodepletion regimen (DRUG), Standard of Care Treatment (DRUG), KYV-101 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06193889?

This trial is sponsored by Kyverna Therapeutics, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06193889 being conducted?

This trial has 14 study locations across California, Florida, Indiana, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial