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ClinicalTrials.gov 9 recruiting now official registry

Gastroesophageal Reflux clinical trials

9 of 26 indexed Gastroesophageal Reflux trials are currently recruiting.

26 US clinical trials · 9 currently recruiting

Gastroesophageal Reflux is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 3 of these trials.

The research picture

Gastroesophageal Reflux has 26 registered US clinical trials, 9 of them open to new participants right now, about 35% of the total.

9
recruiting participants now
35%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: Johns Hopkins University
Phase 11Phase 22Phase 34Phase 41

Active & Recent Trials

26 total, page 1 of 1

RECRUITING NA 800 participants

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

Case Comprehensive Cancer Center

NCT06687603

RECRUITING NA 350 participants

External UES Band (Shaker Pressure Band) and GERD

Medical College of Wisconsin

NCT05697393

RECRUITING Phase 2 247 participants

Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD

Microbiome Health Sciences

NCT05556824

RECRUITING NA 200 participants

Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

Mayo Clinic

NCT04411823

RECRUITING 150 participants

Barrett's Esophagus Related Neoplasia (BERN) Project

Midwest Biomedical Research Foundation

NCT00590239

RECRUITING NA 60 participants

Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

Children's Hospital of Philadelphia

NCT06534359

RECRUITING NA 50 participants

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Mayo Clinic

NCT05976165

RECRUITING NA 30 participants

Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry

Mayo Clinic

NCT06329583

RECRUITING NA 20 participants

Compassionate Use of Domperidone for Refractory Gastroparesis

Children's Mercy Hospital Kansas City

NCT04699591

ACTIVE NOT RECRUITING 600 participants

Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus

Johns Hopkins University

NCT00431756

ACTIVE NOT RECRUITING 500 participants

RETHINK REFLUX Registry

Ethicon Endo-Surgery

NCT04253392

ACTIVE NOT RECRUITING NA 30 participants

Gracie Diet for Gastroesophageal Reflux Disease

Johns Hopkins University

NCT04360252

COMPLETED Phase 3 305 participants

A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn

Takeda

NCT00627016

COMPLETED Phase 2 298 participants

ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD)

Addex Pharma S.A.

NCT00810485

COMPLETED NA 255 participants

Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform

Cedars-Sinai Medical Center

NCT02436057

COMPLETED NA 156 participants

Tolerability Study of a Novel Microbiome Therapeutic in Subjects With Gastroesophageal Reflux Disease

ISOThrive

NCT04491734

COMPLETED NA 121 participants

Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures

Swedish Medical Center

NCT01260935

COMPLETED 85 participants

Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH

Miromatrix Medical

NCT03735862

COMPLETED NA 68 participants

Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children

Johns Hopkins University

NCT00382850

COMPLETED Phase 3 67 participants

Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00259012

COMPLETED Phase 3 60 participants

Study Evaluating Pantoprazole in Children With Gastroesophageal Reflux Disease (GERD)

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00300755

COMPLETED Phase 4 45 participants

Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux

Vanderbilt University

NCT00373997

COMPLETED NA 43 participants

Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease

University of California, San Diego

NCT03619811

COMPLETED Phase 3 41 participants

Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma

Jason Lang, M.D., M.P.H.

NCT03015610

COMPLETED Phase 1 32 participants

Dose-Effect of S-Tenatoprazole-Na(STU-Na) 30 mg, 60 mg, 90 mg and 120 mg in Healthy Volunteers

STEBA France

NCT00284908

COMPLETED NA 10 participants

Evaluation of Gastroesophageal Reflux in Patients on Continuous Positive Airway Pressure Ventilation for Obstructive Sleep Apnea

University of Pennsylvania

NCT00194376

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 2
Phase 3 4
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gastroesophageal Reflux Trial Landscape

26 indexed Gastroesophageal Reflux studies · 9 recruiting (35%).

Phase mix: 5 late (III/IV) vs 3 early (I/II).

Top sponsor: Johns Hopkins University (3 trials), 9 others listed. 26 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gastroesophageal Reflux?

PlainTrial tracks 26 US clinical trials for Gastroesophageal Reflux, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gastroesophageal Reflux?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.