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Gastroesophageal Reflux clinical trials
Every US clinical trial registered for Gastroesophageal Reflux — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
26 US clinical trials · 9 currently recruiting
The research picture
Gastroesophageal Reflux has 26 registered US clinical trials, 9 of them open to new participants right now — about 35% of the total.
- 9
- recruiting participants now
- 35%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Johns Hopkins University
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
Case Comprehensive Cancer Center
NCT06687603
External UES Band (Shaker Pressure Band) and GERD
Medical College of Wisconsin
NCT05697393
Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERD
Microbiome Health Sciences
NCT05556824
Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction
Mayo Clinic
NCT04411823
Barrett's Esophagus Related Neoplasia (BERN) Project
Midwest Biomedical Research Foundation
NCT00590239
Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia
Children's Hospital of Philadelphia
NCT06534359
A Study of Breath Testing for Small Intestinal Bacterial Overgrowth
Mayo Clinic
NCT05976165
Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry
Mayo Clinic
NCT06329583
Compassionate Use of Domperidone for Refractory Gastroparesis
Children's Mercy Hospital Kansas City
NCT04699591
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus
Johns Hopkins University
NCT00431756
RETHINK REFLUX Registry
Ethicon Endo-Surgery
NCT04253392
Gracie Diet for Gastroesophageal Reflux Disease
Johns Hopkins University
NCT04360252
A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn
Takeda
NCT00627016
ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD)
Addex Pharma S.A.
NCT00810485
Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform
Cedars-Sinai Medical Center
NCT02436057
Tolerability Study of a Novel Microbiome Therapeutic in Subjects With Gastroesophageal Reflux Disease
ISOThrive
NCT04491734
Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures
Swedish Medical Center
NCT01260935
Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH
Miromatrix Medical
NCT03735862
Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children
Johns Hopkins University
NCT00382850
Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00259012
Study Evaluating Pantoprazole in Children With Gastroesophageal Reflux Disease (GERD)
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00300755
Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux
Vanderbilt University
NCT00373997
Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease
University of California, San Diego
NCT03619811
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma
Jason Lang, M.D., M.P.H.
NCT03015610
Dose-Effect of S-Tenatoprazole-Na(STU-Na) 30 mg, 60 mg, 90 mg and 120 mg in Healthy Volunteers
STEBA France
NCT00284908
Evaluation of Gastroesophageal Reflux in Patients on Continuous Positive Airway Pressure Ventilation for Obstructive Sleep Apnea
University of Pennsylvania
NCT00194376
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 2 |
| Phase 3 | 4 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Gastroesophageal Reflux Trial Landscape
ClinicalTrials.gov lists 26 US studies indexed under Gastroesophageal Reflux, and 9 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Gastroesophageal Reflux shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Gastroesophageal Reflux is led by Johns Hopkins University with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 26 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Gastroesophageal Reflux?
PlainTrial tracks 26 US clinical trials for Gastroesophageal Reflux, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Gastroesophageal Reflux?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.