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ClinicalTrials.gov 6 recruiting now official registry

Familial Adenomatous Polyposis clinical trials

6 of 11 indexed Familial Adenomatous Polyposis trials are currently recruiting.

11 US clinical trials · 6 currently recruiting

Familial Adenomatous Polyposis is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

Familial Adenomatous Polyposis has 11 registered US clinical trials, 6 of them open to new participants right now, about 55% of the total.

6
recruiting participants now
55%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 12Phase 22Phase 31

Active & Recent Trials

11 total, page 1 of 1

RECRUITING 1,000 participants

A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT04677998

RECRUITING 1,000 participants

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NCT04678011

RECRUITING Phase 1 67 participants

Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)

Recursion Pharmaceuticals

NCT05552755

RECRUITING Phase 1 36 participants

Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

National Cancer Institute (NCI)

NCT05630794

RECRUITING NA 32 participants

Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP)

University of Michigan Rogel Cancer Center

NCT06641310

RECRUITING NA 20 participants

Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis

Abramson Cancer Center at Penn Medicine

NCT06578637

ACTIVE NOT RECRUITING NA 44 participants

CryoBalloon Ablation for Treatment of Duodenal Adenomas

Johns Hopkins University

NCT03847636

ACTIVE NOT RECRUITING Phase 2 30 participants

Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance

Rapamycin Holdings

NCT04230499

COMPLETED Phase 3 171 participants

Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)

Cancer Prevention Pharmaceuticals

NCT01483144

COMPLETED Phase 2 44 participants

Curcumin in Treating Patients With Familial Adenomatous Polyposis

National Cancer Institute (NCI)

NCT00641147

COMPLETED 42 participants

Review of Post-Study Clinical Endoscopy Reports in Follow Up to MAY2016-07-01

National Cancer Institute (NCI)

NCT04674228

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Familial Adenomatous Polyposis Trial Landscape

11 indexed Familial Adenomatous Polyposis studies · 6 recruiting (55%).

Phase mix: 1 late (III/IV) vs 4 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 7 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Familial Adenomatous Polyposis?

PlainTrial tracks 11 US clinical trials for Familial Adenomatous Polyposis, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Familial Adenomatous Polyposis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.