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ACTIVE NOT RECRUITING Phase 2

A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

NCT05276063 · View on ClinicalTrials.gov ↗

Study Summary

The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twice daily (BID) vs. placebo, at 24 weeks in the treatment of subjects with active, moderate to severe thyroid eye disease (TED).

Interventions

  • DRUG Placebo
  • DRUG Linsitinib

Study Locations (20)

California

  • Thrive Health Research — Beverly Hills
  • UC San Diego Health — La Jolla
  • UCLA — Los Angeles
  • Byers Eye Institute - Stanford University — Palo Alto

Florida

  • Bascom Palmer Eye Institute — Miami
  • Center for Excellence in Eye Care — Miami
  • Sarasota Retina Institute — Sarasota

Michigan

  • Kellogg Eye Center — Ann Arbor
  • Kahana Oculoplastic & Orbital Surgery — Livonia

Illinois

  • Chicago Oculofacial Plastic Surgery — Chicago

Iowa

  • Wolfe Eye Clinic — West Des Moines

Massachusetts

  • Mass Eye and Ear — Boston

Missouri

  • Washington University in St. Louis/Barnes Jewish Hospital — Creve Coeur

New York

  • Columbia University — New York

Trial Details

FieldValue
Enrollment Target 90 participants
Start Date 2022-07-01
Est. Completion 2026-09
Phase Phase 2

Sponsor

Sling Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05276063

The ClinicalTrials.gov registry entry for NCT05276063 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sling Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Eye Diseases appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05276063 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Florida, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05276063 about?

NCT05276063 is a clinical study titled "A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)". The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twice daily (BID) vs. placebo, at 24 weeks in the treatment of subjects with active, moderate to severe thyroid eye disease (TED).

What is the current status of trial NCT05276063?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 90 participants. The study started on 2022-07-01. Estimated completion is 2026-09.

What conditions does trial NCT05276063 study?

This clinical trial studies the following conditions: Eye Diseases, Thyroid Eye Disease, Endocrine System Diseases, Graves Ophthalmopathy, Thyroid Diseases. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05276063?

The interventions under investigation include: Placebo (DRUG), Linsitinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05276063?

This trial is sponsored by Sling Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05276063 being conducted?

This trial has 20 study locations across California, Florida, Illinois, Iowa, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial