Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 16 recruiting now official registry

Dystonia clinical trials

Every US clinical trial registered for Dystonia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

29 US clinical trials · 16 currently recruiting

The research picture

Dystonia has 29 registered US clinical trials, 16 of them open to new participants right now — about 55% of the total.

16
recruiting participants now
55%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
5
top sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 5,000 participants

Deep Brain Stimulation (DBS) Retrospective Outcomes Study

Boston Scientific Corporation

NCT03664609

RECRUITING 5,000 participants

Physiological Brain Atlas Development

Vanderbilt University Medical Center

NCT00575081

RECRUITING 1,000 participants

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

Abbott Medical Devices

NCT04071847

RECRUITING 1,000 participants

Clinical Outcomes for Deep Brain Stimulation

Washington University School of Medicine

NCT03992625

RECRUITING NA 1,000 participants

Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

Massachusetts Eye and Ear Infirmary

NCT05317390

RECRUITING 200 participants

Dystonia Genotype-Phenotype Correlation

University of Texas Southwestern Medical Center

NCT03428009

RECRUITING NA 200 participants

Deep Brain Stimulation Surgery for Movement Disorders

National Institute of Neurological Disorders and Stroke (NINDS)

NCT01581580

RECRUITING 198 participants

Studies of the Variable Phenotypic Presentations of Rapid-Onset Dystonia Parkinsonism and Other Movement Disorders

State University of New York at Buffalo

NCT00682513

RECRUITING NA 120 participants

Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

Massachusetts Eye and Ear Infirmary

NCT05150093

RECRUITING 100 participants

A Multicenter Pediatric Deep Brain Stimulation Registry

Boston Children's Hospital

NCT06585618

RECRUITING Phase 2 100 participants

A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia

Vima Therapeutics

NCT07304089

RECRUITING NA 80 participants

Cortical-Basal Ganglia Speech Networks

Massachusetts General Hospital

NCT04286308

RECRUITING NA 75 participants

Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

Children's Hospital Medical Center, Cincinnati

NCT07325175

RECRUITING NA 64 participants

Sleep-specific DBS Therapy in Parkinson's Disease

University of Minnesota

NCT05962489

RECRUITING NA 56 participants

Effects of Exercise on Dystonia Pathophysiology

University of Florida

NCT05663840

RECRUITING Phase 1 40 participants

Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy

Children's Mercy Hospital Kansas City

NCT06554288

ACTIVE NOT RECRUITING NA 25 participants

The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy

University of California, San Francis

NCT03582891

ACTIVE NOT RECRUITING Phase 1 5 participants

Deep Brain Stimulation Surgery for Focal Hand Dystonia

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02911103

COMPLETED 456 participants

Physiological Brain Atlas Development

Ohio State University

NCT01210534

COMPLETED 123 participants

Fatigue in Dystonia (a Single Session, Questionnaire-based Study of Fatigue in Dystonia)

University of Florida

NCT00954408

COMPLETED 118 participants

Brain Function in Focal Dystonia

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00102999

COMPLETED 34 participants

Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene

Children's Hospital Medical Center, Cincinnati

NCT03892798

COMPLETED NA 32 participants

Pathophysiology of Focal Hand Dystonia

National Institute of Neurological Disorders and Stroke (NINDS)

NCT03223623

COMPLETED 31 participants

Cholinergic Receptor Imaging in Dystonia

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02689466

COMPLETED Phase 2 21 participants

Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand

Icahn School of Medicine at Mount Sinai

NCT02107261

COMPLETED 21 participants

Studying Childhood-Onset Hemidystonia

National Institutes of Health Clinical Center (CC)

NCT01432899

COMPLETED NA 12 participants

Physiology, Imaging and Modeling of Essential Tremor

University of Florida

NCT03811405

COMPLETED NA 10 participants

Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia

New York Institute of Technology

NCT03307161

COMPLETED NA 5 participants

Thalamic Deep Brain Stimulation for Secondary Dystonia in Children and Young Adults

University of California, San Francis

NCT03078816

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Dystonia Trial Landscape

ClinicalTrials.gov lists 29 US studies indexed under Dystonia, and 16 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Dystonia shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Dystonia is led by National Institute of Neurological Disorders and Stroke (NINDS) with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 29 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Dystonia?

PlainTrial tracks 29 US clinical trials for Dystonia, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Dystonia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →