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NCT06554288 · ClinicalTrials.gov registry record · Phase 1
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
A Phase 1 study of Dystonia and Genetic Predisposition, sponsored by Children's Mercy Hospital Kansas City.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06554288: Recruiting Phase 1 study of Dystonia and Genetic Predisposition, sponsored by Children's Mercy Hospital Kansas City.
NCT06554288 is a Phase 1 study of Dystonia and Genetic Predisposition that is actively recruiting participants, run by Children's Mercy Hospital Kansas City. The registered enrollment target is 40 participants, below the 539-participant average among 28 other Dystonia trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06554288, a Phase 1 study of Dystonia and Genetic Predisposition, is actively recruiting participants, sponsored by Children's Mercy Hospital Kansas City.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this is impacted by a person's genetics. Information from this study will also be used to design future clinical trials.
Primary Outcome
Cmax will be measured in first-dose pharmacokinetic study on study day 1
Conditions Studied
Interventions
- DRUG Trihexyphenidyl
Study Locations (1)
Missouri
- Children's Mercy Hospital Kansas City - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-10-15 |
| Est. Completion | 2029-12-31 |
| Phase | Phase 1 |
What NCT06554288 shows while recruiting
NCT06554288 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 539-participant average among 28 other Dystonia trials with a reported enrollment target (93% lower).
The record links to 8 conditions, with Dystonia appearing as the primary indexed condition, and to 1 intervention - of which Trihexyphenidyl is the first listed.
NCT06554288 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT06554288 about?
NCT06554288 is a clinical study titled "Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy". This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this is impacted by a person's genetics. Information from this study will a...
What is the current status of trial NCT06554288?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2024-10-15. Estimated completion is 2029-12-31.
What conditions does trial NCT06554288 study?
This clinical trial studies the following conditions: Dystonia, Genetic Predisposition, Pediatric Disorder, Pharmacogenomic Drug Interaction, Cerebral Palsy, Dyskinetic.
What interventions are being tested in trial NCT06554288?
The interventions under investigation include: Trihexyphenidyl (DRUG).
Who is sponsoring clinical trial NCT06554288?
This trial is sponsored by Children's Mercy Hospital Kansas City, which has 184 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06554288 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Dystonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06554288's enrollment target sits among peer trials
40 19th of 28 higher than 10 of 28 other Dystonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Dystonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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