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ClinicalTrials.gov 15 recruiting now official registry

Amyloidosis clinical trials

Every US clinical trial registered for Amyloidosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

29 US clinical trials · 15 currently recruiting

The research picture

Amyloidosis has 29 registered US clinical trials, 15 of them open to new participants right now — about 52% of the total.

15
recruiting participants now
52%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
6
top sponsor: Mayo Clinic

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 20,000 participants

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Sanguine Biosciences

NCT05635266

RECRUITING 5,000 participants

Cancer and Aging Resilience Evaluation in Older Adults With Hematologic Malignancies: The CARE-Heme Registry

University of Alabama at Birmingham

NCT05556928

RECRUITING 2,000 participants

Registry for Adults With Plasma Cell Disorders (PCD's)

UNC Lineberger Comprehensive Cancer Center

NCT03717844

RECRUITING 1,000 participants

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

xCures

NCT06539169

RECRUITING Phase 3 582 participants

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

Eidos Therapeutics, a BridgeBio company

NCT06563895

RECRUITING NA 515 participants

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

Massachusetts General Hospital

NCT05577819

RECRUITING 500 participants

A Study Of MCG In Cardiac Amyloidosis

Mayo Clinic

NCT07218705

RECRUITING Phase 2 150 participants

Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

Oregon Health and Science University

NCT05758493

RECRUITING Phase 1 91 participants

A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.

Alexion Pharmaceuticals

NCT07081646

RECRUITING NA 40 participants

Dietary Reporting in the Amyloidoses

Barbara Ann Karmanos Cancer Institute

NCT05738005

RECRUITING Phase 2 40 participants

Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)

University of Alabama at Birmingham

NCT04991103

RECRUITING Phase 1 37 participants

Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis

University of Texas Southwestern Medical Center

NCT05145816

RECRUITING Phase 1 30 participants

Repeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide to Measure Changes in Organ-Specific Amyloid Load

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06974877

RECRUITING Phase 2 27 participants

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Mayo Clinic

NCT07285044

RECRUITING 20 participants

A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography

Mayo Clinic

NCT07216469

ACTIVE NOT RECRUITING Phase 2 151 participants

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

Janssen Research & Development

NCT05250973

ACTIVE NOT RECRUITING Phase 1 46 participants

Study of Captisol Enabled Melphalan and Pharmacokinetics for Patients With Multiple Myeloma or Light Chain Amyloidosis That Are Receiving an Autologous Transplant.

Memorial Sloan Kettering Cancer Center

NCT02909036

ACTIVE NOT RECRUITING NA 20 participants

Clinical Trial to Assess the Safety of a Novel Scaffold Biomaterial

Mayo Clinic

NCT03584022

COMPLETED 400 participants

Long-term Outcomes of Patients With Primary Amyloidosis After Stem Cell Transplantation

Mayo Clinic

NCT01606280

COMPLETED Phase 3 261 participants

Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis

C.T. Development America

NCT01215747

COMPLETED Phase 3 211 participants

The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Participants Who Have Already Been Treated With ALN-TTR02 (Patisiran)

Alnylam Pharmaceuticals

NCT02510261

COMPLETED 200 participants

Screening for Systemic Amyloidosis Via the Ligamentum Flavum

The Cleveland Clinic

NCT03923920

COMPLETED Phase 1 87 participants

Ixazomib With Cyclophosphamide and Dexamethasone in Patients With Previously Untreated Symptomatic Multiple Myeloma or Light Chain Amyloidosis

Mayo Clinic

NCT01864018

COMPLETED 56 participants

Minimal Residual Disease as a Possible Predictive Factor for Relapse in Patients With AL Amyloidosis

Tufts Medical Center

NCT02555969

COMPLETED 37 participants

Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis

The Cleveland Clinic

NCT03431896

COMPLETED Phase 2 35 participants

Bortezomib and Dexamethasone Followed by High-Dose Melphalan and Stem Cell Transplantation for Primary (AL) Amyloidosis

Boston Medical Center

NCT01083316

COMPLETED Phase 2 32 participants

Ixazomib Rollover Study

Takeda

NCT02924272

COMPLETED NA 20 participants

Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis

Memorial Sloan Kettering Cancer Center

NCT01383759

COMPLETED 19 participants

Evaluation of MyoStrain™ in Clinical Practice

University of Kansas Medical Center

NCT03825224

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 6
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Amyloidosis Trial Landscape

ClinicalTrials.gov lists 29 US studies indexed under Amyloidosis, and 15 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Amyloidosis shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 11 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Amyloidosis is led by Mayo Clinic with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 29 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Amyloidosis?

PlainTrial tracks 29 US clinical trials for Amyloidosis, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Amyloidosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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