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NCT02042820 · ClinicalTrials.gov registry record
Ocular Surface Immune Response in Dry Eye Disease
A clinical trial of Dry Eye Disease, sponsored by Tufts Medical Center.
- Completed
- Registry status
- 67
- Enrollment target
- 1
- Study location
NCT02042820: Completed study of Dry Eye Disease, sponsored by Tufts Medical Center.
NCT02042820 is a study of Dry Eye Disease that has completed, run by Tufts Medical Center. The registered enrollment target is 67 participants, below the 253-participant average among 33 other Dry Eye Disease trials with a reported enrollment target (74% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02042820, a study of Dry Eye Disease, has completed, sponsored by Tufts Medical Center.
- COMPLETED
- Registry status
- 67 participants
- Enrollment target
- 1
- Study location
Study Summary
In vivo confocal microscopy (IVCM) is a sensitive imaging tool for detecting dry eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an in vivo metric to measure inflammatory changes in the central cornea. The objective of the current study is to assess inflammatory response changes in the peripheral cornea and the conjunctiva by analyzing epithelial immune cell density and morphology in these areas and then correlating the IVCM findings to clinical signs and symptoms to establish novel objective imaging biomarkers.
Primary Outcome
Peripheral Corneal Immune cell Status by IVCM • Density of dendritic immune cells • Density of non-dendritic immune cells • Morphology of immune cells
Conditions Studied
Interventions
- OTHER In vivo confocal microscopy (IVCM)
Study Locations (1)
Massachusetts
- Massachusetts Eye and Ear Infirmary - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 67 participants |
| Start Date | 2014-01 |
| Est. Completion | 2015-07 |
What the finished NCT02042820 record still lists
NCT02042820 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 67 participants, a relatively small participant target, below the 253-participant average among 33 other Dry Eye Disease trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Dry Eye Disease appearing as the primary indexed condition, and to 1 intervention - of which In vivo confocal microscopy (IVCM) is the first listed.
NCT02042820 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02042820 about?
NCT02042820 is a clinical study titled "Ocular Surface Immune Response in Dry Eye Disease". In vivo confocal microscopy (IVCM) is a sensitive imaging tool for detecting dry eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an in vivo metric to measure inflammatory changes in the central cornea. The objective of the current study is to assess inflamma...
What is the current status of trial NCT02042820?
This trial is currently completed. The enrollment target is 67 participants. The study started on 2014-01. Estimated completion is 2015-07.
What conditions does trial NCT02042820 study?
This clinical trial studies the following conditions: Dry Eye Disease.
What interventions are being tested in trial NCT02042820?
The interventions under investigation include: In vivo confocal microscopy (IVCM) (OTHER).
Who is sponsoring clinical trial NCT02042820?
This trial is sponsored by Tufts Medical Center, which has 169 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02042820 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Dry Eye Disease
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Where NCT02042820's enrollment target sits among peer trials
67 29th of 33 higher than 5 of 33 other Dry Eye Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Dry Eye Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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