Dompé Farmaceutici S.p.A

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Dompé Farmaceutici S.p.A sits in the top decile of US sponsors by registered trial count (#583 of 15,742 sponsors by registered trial count).

27 total trials 4 currently recruiting 18 completed early-phase tilt top decile by trial count

Dompé Farmaceutici S.p.A: 27 sponsored US clinical trials, 4 recruiting.

Dompé Farmaceutici S.p.A sponsors 27 registered US clinical trials on ClinicalTrials.gov, 4 of them currently recruiting, and 18 completed. 9 of these trials are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Dry Eye Disease, with 2 trials.

Top-decile sponsor footprint

Dompé Farmaceutici S.p.A ranks in the top decile of sponsors by registered trial count (#583 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 35/100

18 of 23 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (78.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

27 total, page 1 of 1

RECRUITING Phase 3

Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)

NCT07453888

RECRUITING Phase 3

An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED

NCT07519902

RECRUITING Phase 2

An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease

NCT07503886

RECRUITING Phase 3

An Efficacy and Safety Study of DFL24498 in the Treatment of AKC

NCT07395232

TERMINATED

Study to Evaluate Corneal Neurosensory Abnormalities in Patients With Sjögren's Dry Eye

NCT06411132

COMPLETED Phase 2

A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.

NCT06244316

COMPLETED

DEFENDO Long Term Follow-up Study in Stage 1 NK Patients

NCT05552261

COMPLETED Phase 2

Add-on Reparixin in Adult Patients With ARDS

NCT05496868

TERMINATED Phase 3

Reparixin add-on Therapy to Standard Care to Limit Progression in Pts With COVID19 & Other Community Acquired Pneumonia

NCT05254990

COMPLETED Phase 3

Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease

NCT05136170

COMPLETED Phase 3

Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Study)

NCT05133180

COMPLETED Phase 3

Study on Efficacy and Safety of Reparixin in the Treatment of Hospitalized Patients With Severe COVID-19 Pneumonia.

NCT04878055

TERMINATED Phase 2

A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function

NCT04628481

TERMINATED Phase 2

A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at Baseline.

NCT04899271

COMPLETED Phase 4

Study to Evaluate OXERVATE® in Patients With Stage 1 Neurotrophic Keratitis

NCT04485546

COMPLETED Phase 2

A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye

NCT03982368

COMPLETED Phase 1

Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers

NCT03836859

COMPLETED Phase 2

An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Eye

NCT03019627

COMPLETED Phase 1

Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma

NCT02855450

COMPLETED Phase 2

A Double-blind Study of Paclitaxel in Combination With Reparixin or Placebo for Metastatic Triple-Negative Breast Cancer

NCT02370238

COMPLETED Phase 2

Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK

NCT02227147

COMPLETED Phase 2

Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation

NCT01967888

TERMINATED Phase 2

Pilot Study to Evaluate Safety & Biological Effects of Orally Administered Reparixin in Early Breast Cancer

NCT01861054

COMPLETED Phase 3

Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation

NCT01817959

COMPLETED Phase 1

Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC)

NCT02001974

COMPLETED Phase 2

Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation

NCT00248040

COMPLETED Phase 2

Repertaxin in Prevention of Primary Graft Dysfunction After Lung Transplantation

NCT00224406

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 13
Phase 3 8
Phase 4 1

What is open in the Dompé Farmaceutici S.p.A pipeline

4 recruiting of 27 indexed (15% open); 18 completed (67%).

Phase mix: 9 late (III/IV) vs 16 early (I/II) (early-phase heavy).

Top condition: Dry Eye Disease (2 trials), 5 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Dompé Farmaceutici S.p.A: open-pipeline peers nationwide

Peers matched on 27 registered trials and 15% open enrollment, not the therapeutic-area sidebar.

Dompé Farmaceutici S.p.A sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 0%5%10%15%20% Total trials Recruiting share Dompé Farmaceutici S.p.AAkron Children's HospitalArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)AVEO PharmaceuticalsFlorida Atlantic UniversityVanderbilt-Ingram Cancer CenterUniversity of RochesterLoma Linda UniversityUniversity of Washington
Dompé Farmaceutici S.p.A sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Dompé Farmaceutici S.p.A sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 27 trials (± recruiting share)

Sponsors near 15% open enrollment (± trial volume)

What to do with this Dompé Farmaceutici S.p.A page

27 registered trials is a research-attention snapshot, not an endorsement of Dompé Farmaceutici S.p.A or any single study.

  • 4 of Dompé Farmaceutici S.p.A's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Dry Eye Disease is the condition Dompé Farmaceutici S.p.A studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Dry Eye Disease trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Dompé Farmaceutici S.p.A pipeline card: 27 registered trials from official public datasets.Report a data error.