Aldeyra Therapeutics

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Aldeyra Therapeutics sits in the top decile of US sponsors by registered trial count (#604 of 15,742 sponsors by registered trial count).

26 total trials 1 currently recruiting 25 completed early-phase tilt top decile by trial count

Aldeyra Therapeutics: 26 sponsored US clinical trials, 1 recruiting.

Aldeyra Therapeutics sponsors 26 registered US clinical trials on ClinicalTrials.gov, 1 of them currently recruiting, and 25 completed. 10 of these trials are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Dry Eye, with 2 trials.

Top-decile sponsor footprint

Aldeyra Therapeutics ranks in the top decile of sponsors by registered trial count (#604 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

A 90/100

25 of 25 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (100.0%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

26 total, page 1 of 1

RECRUITING Phase 3

A Clinical Trial Evaluating Patients With Primary Vitreoretinal Lymphoma

NCT07402876

COMPLETED Phase 2

A Clinical Trial Investigating the Safety and Efficacy of Subjects With Alcohol Associated Hepatitis (Part 1)

NCT06685692

COMPLETED Phase 3

A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease

NCT06493604

COMPLETED Phase 3

A Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease

NCT06424444

COMPLETED Phase 2

A Clinical Trial in Subjects With Atopic Dermatitis (Part 1)

NCT05717920

COMPLETED Phase 2

A Study in Subjects With Retinitis Pigmentosa

NCT05392179

COMPLETED Phase 2

A Clinical Trial to Evaluate the Safety and Efficacy in Subjects With Chronic Cough

NCT05392192

COMPLETED Phase 1

A Clinical Trial to Evaluate the Safety and Efficacy of ADX-629 in in Subjects With Elevated Ethanol Levels

NCT05487404

COMPLETED Phase 3

The TRANQUILITY 2 Trial: A Phase 3 Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease

NCT05062330

COMPLETED Phase 2

A Clinical Trial to Assess Subjects With Dry Eye Disease.

NCT04971031

COMPLETED Phase 2

A Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of Subjects With Plaque Psoriasis

NCT04908514

COMPLETED Phase 2

A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Evaluate the Safety, Tolerability, Efficacy, and Pharmacodynamics for the Treatment of COVID-19.

NCT04847544

COMPLETED Phase 3

A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease

NCT04735393

COMPLETED Phase 2

The TRANQUILITY Trial: Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease

NCT04674358

COMPLETED Phase 3

The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy

NCT04136366

COMPLETED Phase 2

A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial of Reproxalap to Assess the Safety and Efficacy in Subjects With Dry Eye Disease

NCT03916042

COMPLETED Phase 3

The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease

NCT03879863

COMPLETED Phase 1

A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

NCT03660878

COMPLETED Phase 3

RESET Trial - Part 1 - A Phase 3 Trial in Subjects With Sjögren-Larsson Syndrome (SLS)

NCT03445650

COMPLETED Phase 3

ALLEVIATE Trial - A Phase 3 Trial in Subjects With Allergic Conjunctivitis

NCT03494504

COMPLETED Phase 2

A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease

NCT03404115

COMPLETED Phase 2

A Randomized, Double Masked, Clinical Study of Subjects With Dry Eye Syndrome

NCT03162783

COMPLETED Phase 3

SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis.

NCT03131154

COMPLETED Phase 2

A Study of ADX-102 in Subjects With Allergic Conjunctivitis

NCT03012165

COMPLETED Phase 2

A Study of Topical NS2 Cream to Treat Ichthyosis in Sjögren-Larsson Syndrome (SLS)

NCT02402309

COMPLETED Phase 2

A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis

NCT02406209

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 14
Phase 3 10

What is open in the Aldeyra Therapeutics pipeline

1 recruiting of 26 indexed (4% open); 25 completed (96%).

Phase mix: 10 late (III/IV) vs 16 early (I/II) (early-phase heavy).

Top condition: Dry Eye (2 trials), 3 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Aldeyra Therapeutics: open-pipeline peers nationwide

Peers matched on 26 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

Aldeyra Therapeutics sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 050100150200 0%5%10%15%20% Total trials Recruiting share Aldeyra TherapeuticsAbbott Diabetes CareCalifornia Polytechnic State University-San Luis ObispoDexComHarvard Medical School (HMS and HSDM)MaineHealthMedtronic Spinal and BiologicsOklahoma State UniversityViiV Healthcare
Aldeyra Therapeutics sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Aldeyra Therapeutics sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 26 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this Aldeyra Therapeutics page

26 registered trials is a research-attention snapshot, not an endorsement of Aldeyra Therapeutics or any single study.

  • 1 of Aldeyra Therapeutics's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Dry Eye is the condition Aldeyra Therapeutics studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Dry Eye trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Aldeyra Therapeutics pipeline card: 26 registered trials from official public datasets.Report a data error.