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ClinicalTrials.gov 63 recruiting now official registry

Diabetes Mellitus, Type 2 clinical trials

63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.

351 US clinical trials · 63 currently recruiting

Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.

The research picture

Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.

63
recruiting participants now
18%
of trials open to enrollment
100
in Phase 3–4 (later-stage)
48
top sponsor: Novo Nordisk A/S
Phase 142Phase 238Phase 374Phase 426

Active & Recent Trials

351 total, page 7 of 8

COMPLETED NA 34 participants

Motivational Interviewing and Cognitive Behavioral Therapy-based Intervention for Cardiovascular Disease Prevention Amongst American Indians With Diabetic and Depressive Symptoms

University of Washington

NCT01892124

COMPLETED Phase 4 34 participants

PROTOCOL 3: Role of the Renal Nerves in the Increase in EGP in Response to Glucosuria

The University of Texas Health Science Center at San Antonio

NCT03168295

COMPLETED NA 34 participants

Combining Flash Glucose Monitoring and Online Peer Support to Improve Outcomes in Hispanics With Type 2 Diabetes

University of Utah

NCT03799796

COMPLETED Phase 1 32 participants

A Study With RO5095932 in Patients With Type 2 Diabetes on Stable Metformin Therapy.

Hoffmann-La Roche

NCT01017302

COMPLETED Phase 1 30 participants

A Drug Interaction Study of Albiglutide and Digoxin

GlaxoSmithKline

NCT01147718

COMPLETED Phase 1 29 participants

A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of JNJ-28431754 in Patients With Type 2 Diabetes Mellitus

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT01177163

COMPLETED Phase 1 29 participants

A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function

GlaxoSmithKline

NCT00501462

COMPLETED 27 participants

Mitochondrial Methylation in Type 2 Diabetes

University of Arizona

NCT04126551

COMPLETED Phase 1 27 participants

A Study to Assess the Safety of Repeated Doses of GSK189075 and WELLBUTRIN SR in Healthy Male Subjects

GlaxoSmithKline

NCT00625859

COMPLETED NA 27 participants

A Continuous Glucose Monitor Based Insulin Bolus Calculator

Welldoc

NCT05229445

COMPLETED NA 26 participants

The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

Physicians Committee for Responsible Medicine

NCT06106035

COMPLETED NA 26 participants

A Multi-level Intervention to Increase Access and Use of the Patient Portal

Yale University

NCT05180721

COMPLETED Phase 4 25 participants

Effect of Thiazolidinedione Treatment Vascular Risk Markers

University of Arkansas

NCT00571506

COMPLETED Phase 1 25 participants

Quitting Caffeine for Better Glucose Metabolism

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT01030796

COMPLETED Phase 2 24 participants

Pharmacodynamic Study of the Effect of INCB013739 on Insulin Sensitivity in Obese, Type 2 Diabetic Subjects

Incyte Corporation

NCT00478322

COMPLETED NA 24 participants

The Impact of Exercise Counseling on Exercise Behavior in People With Type 2 Diabetes: A Randomized Clinical Trial

University of Central Arkansas

NCT00910507

COMPLETED Phase 1 24 participants

Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes

University of Colorado, Denver

NCT03620773

COMPLETED NA 24 participants

Carnitine and Liver Mitochondria Fatty Acid Processing

Pennington Biomedical Research Center

NCT03193125

COMPLETED Phase 2 24 participants

Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes

VA Office of Research and Development

NCT05205005

COMPLETED NA 24 participants

Diabetes Communication and Treatment Burden

University of California, Davis

NCT04568382

COMPLETED NA 24 participants

Behavioral Family Systems Therapy for Teens With Type 2 Diabetes

Nemours Children's Clinic

NCT05422807

COMPLETED Phase 4 24 participants

"TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM

Pennington Biomedical Research Center

NCT00402012

COMPLETED Phase 1 24 participants

Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects

Gan and Lee Pharmaceuticals, U

NCT05328726

COMPLETED NA 24 participants

Health Mindset as a Driver of Efficacy of a Diabetes Prevention Program in the Blackfeet Community

Montana State University

NCT04571723

COMPLETED Phase 2 23 participants

Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM)

Halozyme Therapeutics

NCT00916357

COMPLETED Phase 3 21 participants

Effect of Vildagliptin on Fat and Muscle Metabolism in Patients With Type 2 Diabetes

Novartis

NCT00380445

COMPLETED Phase 4 20 participants

Afrezza® Dosing Optimization Study

Mannkind Corporation

NCT04849845

COMPLETED NA 20 participants

Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis

Purdue University

NCT05349903

COMPLETED Phase 1 20 participants

Effect of Liraglutide on the Beta-cell Responsiveness in Subjects With Type 2 Diabetes Compared to a Healthy Control Group

Novo Nordisk A/S

NCT01511185

COMPLETED Phase 1 20 participants

A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose

Novo Nordisk A/S

NCT05689099

COMPLETED NA 20 participants

DM-BOOST Para Latinx: a Diabetes Mellitus Program Using Behavioral Economics to Optimize Outreach and Self-management Support With Technology for Latinx Patients

Daniel Amante

NCT05583877

COMPLETED 18 participants

SGLT2 Inhibition in Diabetes and Heart Failure

Virginia Commonwealth University

NCT02862067

COMPLETED Phase 1 16 participants

Allogeneic Mesenchymal Human Stem Cells Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects

Joshua M Hare

NCT02886884

COMPLETED NA 16 participants

Whole Grains, Gastric Emptying and Glycemic Response

Purdue University

NCT03467659

COMPLETED Phase 3 16 participants

A Pilot Intervention Study of Health Coaching to Promote Diabetes Self-Care in the Community

Northwestern University

NCT01695278

COMPLETED Phase 2 16 participants

Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 in Type 2 Diabetes Patients Taking Metformin

GlaxoSmithKline

NCT01929863

COMPLETED 16 participants

Production of Free Fatty Acids From Blood Triglycerides

Mayo Clinic

NCT00911482

COMPLETED Early Phase 1 15 participants

Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I

St. Louis University

NCT03445702

COMPLETED NA 15 participants

Practice Based Nutrition Intervention-2

Physicians Committee for Responsible Medicine

NCT01700868

COMPLETED Phase 1 14 participants

A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets

Novo Nordisk A/S

NCT04817644

COMPLETED Phase 2 14 participants

A Comparative Study of Aleglitazar and Actos in Patients With Type 2 Diabetes Mellitus and New York Heart Association (NYHA) Class II Heart Failure.

Hoffmann-La Roche

NCT00461058

COMPLETED Phase 1 12 participants

Multiple Dose Safety Toelrability, Pharmacokinetics and Midazolam Interaction In Healthy Overweight And Obese Subjects

Pfizer

NCT01757756

COMPLETED Phase 1 12 participants

A Study to Evaluate and Study Drug Levels in Blood Plasma When Giving High Doses of GSK189075 to Healthy Volunteers

GlaxoSmithKline

NCT00501930

COMPLETED Phase 3 10 participants

A Study to Assess the Effects of Vildagliptin on Gastric Emptying in Patients With Type 2 Diabetes

Novartis Pharmaceuticals

NCT00351507

COMPLETED NA 10 participants

Brief CBT Interventions Delivered by Nurse Care Managers to Improve Type 2 Diabetes Outcomes: Pilot Study

University of Pittsburgh

NCT02081573

COMPLETED Early Phase 1 9 participants

Low Dose Fat-Induced Insulin Resistance

University of Pennsylvania

NCT03479671

COMPLETED NA 9 participants

Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness

Katherine Vickery

NCT06025721

COMPLETED NA 8 participants

Effect of a High Protein Diet on the 24-hour Profile of Ghrelin, GH (Growth Hormone) and IGF-1 (Insulin-like Growth Factor-1)

US Department of Veterans Affairs

NCT00108225

COMPLETED NA 7 participants

INDIGO-2: The Effect of High Water Intake on Glucose Regulation in Low-drinkers

Arizona State University

NCT04076995

COMPLETED NA 3 participants

OT-Led Interdisciplinary Diabetes Self-Management Prgm

Arizona State University

NCT03821662

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 38
Phase 3 74
Phase 4 26

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 2 Trial Landscape

351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).

Phase mix: 100 late (III/IV) vs 80 early (I/II).

Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 2?

PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 2?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.