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Diabetes Mellitus, Type 2 clinical trials
63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.
351 US clinical trials · 63 currently recruiting
Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.
The research picture
Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.
- 63
- recruiting participants now
- 18%
- of trials open to enrollment
- 100
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
351 total, page 7 of 8
Motivational Interviewing and Cognitive Behavioral Therapy-based Intervention for Cardiovascular Disease Prevention Amongst American Indians With Diabetic and Depressive Symptoms
University of Washington
NCT01892124
PROTOCOL 3: Role of the Renal Nerves in the Increase in EGP in Response to Glucosuria
The University of Texas Health Science Center at San Antonio
NCT03168295
Combining Flash Glucose Monitoring and Online Peer Support to Improve Outcomes in Hispanics With Type 2 Diabetes
University of Utah
NCT03799796
A Study With RO5095932 in Patients With Type 2 Diabetes on Stable Metformin Therapy.
Hoffmann-La Roche
NCT01017302
A Drug Interaction Study of Albiglutide and Digoxin
GlaxoSmithKline
NCT01147718
A Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of JNJ-28431754 in Patients With Type 2 Diabetes Mellitus
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
NCT01177163
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
GlaxoSmithKline
NCT00501462
Mitochondrial Methylation in Type 2 Diabetes
University of Arizona
NCT04126551
A Study to Assess the Safety of Repeated Doses of GSK189075 and WELLBUTRIN SR in Healthy Male Subjects
GlaxoSmithKline
NCT00625859
A Continuous Glucose Monitor Based Insulin Bolus Calculator
Welldoc
NCT05229445
The Effect of a Low-fat Vegan Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes
Physicians Committee for Responsible Medicine
NCT06106035
A Multi-level Intervention to Increase Access and Use of the Patient Portal
Yale University
NCT05180721
Effect of Thiazolidinedione Treatment Vascular Risk Markers
University of Arkansas
NCT00571506
Quitting Caffeine for Better Glucose Metabolism
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT01030796
Pharmacodynamic Study of the Effect of INCB013739 on Insulin Sensitivity in Obese, Type 2 Diabetic Subjects
Incyte Corporation
NCT00478322
The Impact of Exercise Counseling on Exercise Behavior in People With Type 2 Diabetes: A Randomized Clinical Trial
University of Central Arkansas
NCT00910507
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
University of Colorado, Denver
NCT03620773
Carnitine and Liver Mitochondria Fatty Acid Processing
Pennington Biomedical Research Center
NCT03193125
Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
VA Office of Research and Development
NCT05205005
Diabetes Communication and Treatment Burden
University of California, Davis
NCT04568382
Behavioral Family Systems Therapy for Teens With Type 2 Diabetes
Nemours Children's Clinic
NCT05422807
"TAKE TIME" Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM
Pennington Biomedical Research Center
NCT00402012
Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects
Gan and Lee Pharmaceuticals, U
NCT05328726
Health Mindset as a Driver of Efficacy of a Diabetes Prevention Program in the Blackfeet Community
Montana State University
NCT04571723
Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM)
Halozyme Therapeutics
NCT00916357
Effect of Vildagliptin on Fat and Muscle Metabolism in Patients With Type 2 Diabetes
Novartis
NCT00380445
Afrezza® Dosing Optimization Study
Mannkind Corporation
NCT04849845
Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis
Purdue University
NCT05349903
Effect of Liraglutide on the Beta-cell Responsiveness in Subjects With Type 2 Diabetes Compared to a Healthy Control Group
Novo Nordisk A/S
NCT01511185
A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose
Novo Nordisk A/S
NCT05689099
DM-BOOST Para Latinx: a Diabetes Mellitus Program Using Behavioral Economics to Optimize Outreach and Self-management Support With Technology for Latinx Patients
Daniel Amante
NCT05583877
SGLT2 Inhibition in Diabetes and Heart Failure
Virginia Commonwealth University
NCT02862067
Allogeneic Mesenchymal Human Stem Cells Infusion Therapy for Endothelial DySfunctiOn in Diabetic Subjects
Joshua M Hare
NCT02886884
Whole Grains, Gastric Emptying and Glycemic Response
Purdue University
NCT03467659
A Pilot Intervention Study of Health Coaching to Promote Diabetes Self-Care in the Community
Northwestern University
NCT01695278
Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 in Type 2 Diabetes Patients Taking Metformin
GlaxoSmithKline
NCT01929863
Production of Free Fatty Acids From Blood Triglycerides
Mayo Clinic
NCT00911482
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I
St. Louis University
NCT03445702
Practice Based Nutrition Intervention-2
Physicians Committee for Responsible Medicine
NCT01700868
A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets
Novo Nordisk A/S
NCT04817644
A Comparative Study of Aleglitazar and Actos in Patients With Type 2 Diabetes Mellitus and New York Heart Association (NYHA) Class II Heart Failure.
Hoffmann-La Roche
NCT00461058
Multiple Dose Safety Toelrability, Pharmacokinetics and Midazolam Interaction In Healthy Overweight And Obese Subjects
Pfizer
NCT01757756
A Study to Evaluate and Study Drug Levels in Blood Plasma When Giving High Doses of GSK189075 to Healthy Volunteers
GlaxoSmithKline
NCT00501930
A Study to Assess the Effects of Vildagliptin on Gastric Emptying in Patients With Type 2 Diabetes
Novartis Pharmaceuticals
NCT00351507
Brief CBT Interventions Delivered by Nurse Care Managers to Improve Type 2 Diabetes Outcomes: Pilot Study
University of Pittsburgh
NCT02081573
Low Dose Fat-Induced Insulin Resistance
University of Pennsylvania
NCT03479671
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
Katherine Vickery
NCT06025721
Effect of a High Protein Diet on the 24-hour Profile of Ghrelin, GH (Growth Hormone) and IGF-1 (Insulin-like Growth Factor-1)
US Department of Veterans Affairs
NCT00108225
INDIGO-2: The Effect of High Water Intake on Glucose Regulation in Low-drinkers
Arizona State University
NCT04076995
OT-Led Interdisciplinary Diabetes Self-Management Prgm
Arizona State University
NCT03821662
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 38 |
| Phase 3 | 74 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).
Phase mix: 100 late (III/IV) vs 80 early (I/II).
Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.