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Diabetes Mellitus, Type 2 clinical trials
63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.
351 US clinical trials · 63 currently recruiting
Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.
The research picture
Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.
- 63
- recruiting participants now
- 18%
- of trials open to enrollment
- 100
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
351 total, page 6 of 8
A 2-week Trial Of PF-04991532 In Patients With Type 2 Diabetes
Pfizer
NCT01469065
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of KQ-791 in Diabetes Mellitus
Kaneq Bioscience Limited
NCT02445911
T-UP: Engaging Vulnerable Students in Diabetes Prevention
University of California, Los Angeles
NCT06385015
Assessment of Mealtime Bolus Insulin Behavior
Eli Lilly and Company
NCT03368807
Safety, Pharmacokinetics and Efficacy of Bimagrumab in Overweight and Obese Patients With Type 2 Diabetes
Novartis Pharmaceuticals
NCT03005288
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00813228
Food and Education Effects on Diabetes Study
Johns Hopkins University
NCT04034511
PDD in Type 2 Diabetes w/wo Diastolic Dysfunction
Mayo Clinic
NCT03744975
A Study of the Treatment of Type 2 Diabetes With an Insulin Infusion Pump
Novo Nordisk A/S
NCT00115973
Diabetes Visual Function Supplement Study
ZeaVision
NCT01646047
Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy
The Cleveland Clinic
NCT06533527
Development and Feasibility Testing of DM-BOOST Intervention.
Daniel Amante
NCT04710940
A Study of Multiple Doses of LY2922470 in Participants With Diabetes
Eli Lilly and Company
NCT01867216
A Study in Type 2 Diabetic Subjects on Stable Metformin Therapy to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administering Single and Multiple Oral Doses of GSK1292263
GlaxoSmithKline
NCT01128621
Multiple Escalating Oral Doses Study of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
Pfizer
NCT04305587
Determining the Effect on Patients of Internet-Based Diabetes Disease Management
Robert Wood Johnson Foundation
NCT00220207
A Study Of PF-05175157 In Healthy Volunteers
Pfizer
NCT01274663
The Effect of NN1250 in Subjects With Type 2 Diabetes of Different Race and/or Ethnic Origin
Novo Nordisk A/S
NCT01043510
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
University of Colorado, Denver
NCT03077360
Single Dose Pharmacokinetics of Repaglinide, Metformin and Combination Tablet in Healthy Volunteers
Novo Nordisk A/S
NCT01489644
Effect of Renal Impairment on the Pharmacokinetics of NN9535
Novo Nordisk A/S
NCT00833716
Comparison of Glycemic Control Achieved With 2 Different Needles
Novo Nordisk A/S
NCT00572052
Heart Rate Variability in Response to Metformin Challenge
Woodinville Psychiatric Associates
NCT02500628
Multiple Dose Study Of PF-04937319 In Patients With Type 2 Diabetes
Pfizer
NCT01272804
Onduo Virtual Diabetes Clinic Study
Verily Life Sciences
NCT03865381
In-patient Study With GSK716155 In Patients With Type 2 Diabetes Mellitus
GlaxoSmithKline
NCT00354536
Pharmacodynamic Evaluation of PL2200 Versus Enteric-Coated Aspirin in Diabetic Patients
PLx Pharma
NCT02008942
A Safety, Pharmacokinetics and Pharmacodynamics Study of RO6811135 in Patients With Type 2 Diabetes Mellitus
Hoffmann-La Roche
NCT01789788
Advanced Glycation Endproducts and Bone Material Strength in T2D Treated With Pyridoxamine
Columbia University
NCT03778580
Diabetes Risk Education and Communication Trial
Northwestern University
NCT03283657
A Study Using Flash Glucose Measurements for a New Once-weekly Insulin (Insulin Icodec) in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 9)
Novo Nordisk A/S
NCT05823948
Virta Intervention in CommuniTies in cOloRado (VICTOR-Pilot)
Colorado Prevention Center
NCT04807218
Exercise and the Receptor for Advanced Glycation End Products (RAGE)
University of Michigan
NCT03534687
A Study To Assess The Safety And Tolerability Of GSK189075 When Given With A Total Daily Dose Of >/ 2000mg of Metformin
GlaxoSmithKline
NCT00519480
Exercise Training for Patients With Poor Leg Circulation
US Department of Veterans Affairs
NCT00118560
A Study to Evaluate the Effect of ORMD-0801 in Patients With Type 2 Diabetes Mellitus
Oramed
NCT04564846
Green Digital Diabetes Waste Project
Florida State University
NCT06071325
Yoga as a Complementary Therapy for Adults With Type 2 Diabetes
The Miriam Hospital
NCT02607566
Pharmacokinetics, Pharmacodynamics, and Safety of Alogliptin in Children, Adolescents and Adults With Type 2 Diabetes Mellitus
Takeda
NCT00957268
Models of Nutrition From Continuous Glucose Monitors
Texas A&M University
NCT04991142
A Study of RO6807952 in Patients With Diabetes Mellitus Type 2
Hoffmann-La Roche
NCT01358929
Albiglutide Glucose Clamp Study in Subjects With Type 2 Diabetes
GlaxoSmithKline
NCT01475734
Mechanism of Action and Efficacy of Muraglitazar in Type 2 Diabetes
Bristol-Myers Squibb
NCT00094991
Study OF PF-06882961 IN Participants With Type 2 Diabetes Mellitus With Varying Degrees OF Renal Impairment AND Participants Without Renal Impairment
Pfizer
NCT04616027
Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI
University of Florida
NCT03437044
Effect of Empagliflozin Kinetics on Renal Glucose Reabsorption in Patients With Type II Diabetes and Healthy Controls
Boehringer Ingelheim
NCT01867307
Diabetes Homeless Medication Support
Hennepin Healthcare Research Institute
NCT05258630
A Study to Compare the Safety and Drug Levels in Blood When Using Various Forms of GSK189075 Given to Healthy Subjects
GlaxoSmithKline
NCT00559884
Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid
University of Missouri-Columbia
NCT03648996
Redox Imbalance and the Development of Cystic Fibrosis Diabetes
Emory University
NCT02202876
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 38 |
| Phase 3 | 74 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).
Phase mix: 100 late (III/IV) vs 80 early (I/II).
Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.