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ClinicalTrials.gov 63 recruiting now official registry

Diabetes Mellitus, Type 2 clinical trials

63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.

351 US clinical trials · 63 currently recruiting

Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.

The research picture

Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.

63
recruiting participants now
18%
of trials open to enrollment
100
in Phase 3–4 (later-stage)
48
top sponsor: Novo Nordisk A/S
Phase 142Phase 238Phase 374Phase 426

Active & Recent Trials

351 total, page 6 of 8

COMPLETED Phase 1 82 participants

A 2-week Trial Of PF-04991532 In Patients With Type 2 Diabetes

Pfizer

NCT01469065

COMPLETED Phase 1 81 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of KQ-791 in Diabetes Mellitus

Kaneq Bioscience Limited

NCT02445911

COMPLETED NA 80 participants

T-UP: Engaging Vulnerable Students in Diabetes Prevention

University of California, Los Angeles

NCT06385015

COMPLETED 79 participants

Assessment of Mealtime Bolus Insulin Behavior

Eli Lilly and Company

NCT03368807

COMPLETED Phase 2 78 participants

Safety, Pharmacokinetics and Efficacy of Bimagrumab in Overweight and Obese Patients With Type 2 Diabetes

Novartis Pharmaceuticals

NCT03005288

COMPLETED Phase 1 76 participants

Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00813228

COMPLETED NA 74 participants

Food and Education Effects on Diabetes Study

Johns Hopkins University

NCT04034511

COMPLETED Phase 2 72 participants

PDD in Type 2 Diabetes w/wo Diastolic Dysfunction

Mayo Clinic

NCT03744975

COMPLETED Phase 1 71 participants

A Study of the Treatment of Type 2 Diabetes With an Insulin Infusion Pump

Novo Nordisk A/S

NCT00115973

COMPLETED NA 70 participants

Diabetes Visual Function Supplement Study

ZeaVision

NCT01646047

COMPLETED Phase 4 69 participants

Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

The Cleveland Clinic

NCT06533527

COMPLETED NA 66 participants

Development and Feasibility Testing of DM-BOOST Intervention.

Daniel Amante

NCT04710940

COMPLETED Phase 1 66 participants

A Study of Multiple Doses of LY2922470 in Participants With Diabetes

Eli Lilly and Company

NCT01867216

COMPLETED Phase 2 66 participants

A Study in Type 2 Diabetic Subjects on Stable Metformin Therapy to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administering Single and Multiple Oral Doses of GSK1292263

GlaxoSmithKline

NCT01128621

COMPLETED Phase 1 66 participants

Multiple Escalating Oral Doses Study of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus

Pfizer

NCT04305587

COMPLETED NA 63 participants

Determining the Effect on Patients of Internet-Based Diabetes Disease Management

Robert Wood Johnson Foundation

NCT00220207

COMPLETED Phase 1 63 participants

A Study Of PF-05175157 In Healthy Volunteers

Pfizer

NCT01274663

COMPLETED Phase 1 63 participants

The Effect of NN1250 in Subjects With Type 2 Diabetes of Different Race and/or Ethnic Origin

Novo Nordisk A/S

NCT01043510

COMPLETED NA 62 participants

Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans

University of Colorado, Denver

NCT03077360

COMPLETED Phase 1 62 participants

Single Dose Pharmacokinetics of Repaglinide, Metformin and Combination Tablet in Healthy Volunteers

Novo Nordisk A/S

NCT01489644

COMPLETED Phase 1 62 participants

Effect of Renal Impairment on the Pharmacokinetics of NN9535

Novo Nordisk A/S

NCT00833716

COMPLETED Phase 4 62 participants

Comparison of Glycemic Control Achieved With 2 Different Needles

Novo Nordisk A/S

NCT00572052

COMPLETED Phase 2 61 participants

Heart Rate Variability in Response to Metformin Challenge

Woodinville Psychiatric Associates

NCT02500628

COMPLETED Phase 1 61 participants

Multiple Dose Study Of PF-04937319 In Patients With Type 2 Diabetes

Pfizer

NCT01272804

COMPLETED NA 60 participants

Onduo Virtual Diabetes Clinic Study

Verily Life Sciences

NCT03865381

COMPLETED Phase 2 60 participants

In-patient Study With GSK716155 In Patients With Type 2 Diabetes Mellitus

GlaxoSmithKline

NCT00354536

COMPLETED Phase 3 57 participants

Pharmacodynamic Evaluation of PL2200 Versus Enteric-Coated Aspirin in Diabetic Patients

PLx Pharma

NCT02008942

COMPLETED Phase 1 56 participants

A Safety, Pharmacokinetics and Pharmacodynamics Study of RO6811135 in Patients With Type 2 Diabetes Mellitus

Hoffmann-La Roche

NCT01789788

COMPLETED NA 55 participants

Advanced Glycation Endproducts and Bone Material Strength in T2D Treated With Pyridoxamine

Columbia University

NCT03778580

COMPLETED NA 53 participants

Diabetes Risk Education and Communication Trial

Northwestern University

NCT03283657

COMPLETED Phase 3 51 participants

A Study Using Flash Glucose Measurements for a New Once-weekly Insulin (Insulin Icodec) in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 9)

Novo Nordisk A/S

NCT05823948

COMPLETED NA 51 participants

Virta Intervention in CommuniTies in cOloRado (VICTOR-Pilot)

Colorado Prevention Center

NCT04807218

COMPLETED NA 50 participants

Exercise and the Receptor for Advanced Glycation End Products (RAGE)

University of Michigan

NCT03534687

COMPLETED Phase 1 50 participants

A Study To Assess The Safety And Tolerability Of GSK189075 When Given With A Total Daily Dose Of >/ 2000mg of Metformin

GlaxoSmithKline

NCT00519480

COMPLETED NA 50 participants

Exercise Training for Patients With Poor Leg Circulation

US Department of Veterans Affairs

NCT00118560

COMPLETED Phase 2 49 participants

A Study to Evaluate the Effect of ORMD-0801 in Patients With Type 2 Diabetes Mellitus

Oramed

NCT04564846

COMPLETED 49 participants

Green Digital Diabetes Waste Project

Florida State University

NCT06071325

COMPLETED NA 48 participants

Yoga as a Complementary Therapy for Adults With Type 2 Diabetes

The Miriam Hospital

NCT02607566

COMPLETED Phase 1 46 participants

Pharmacokinetics, Pharmacodynamics, and Safety of Alogliptin in Children, Adolescents and Adults With Type 2 Diabetes Mellitus

Takeda

NCT00957268

COMPLETED 45 participants

Models of Nutrition From Continuous Glucose Monitors

Texas A&M University

NCT04991142

COMPLETED Phase 1 45 participants

A Study of RO6807952 in Patients With Diabetes Mellitus Type 2

Hoffmann-La Roche

NCT01358929

COMPLETED Phase 2 44 participants

Albiglutide Glucose Clamp Study in Subjects With Type 2 Diabetes

GlaxoSmithKline

NCT01475734

COMPLETED Phase 3 42 participants

Mechanism of Action and Efficacy of Muraglitazar in Type 2 Diabetes

Bristol-Myers Squibb

NCT00094991

COMPLETED Phase 1 42 participants

Study OF PF-06882961 IN Participants With Type 2 Diabetes Mellitus With Varying Degrees OF Renal Impairment AND Participants Without Renal Impairment

Pfizer

NCT04616027

COMPLETED Phase 4 40 participants

Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI

University of Florida

NCT03437044

COMPLETED Phase 2 39 participants

Effect of Empagliflozin Kinetics on Renal Glucose Reabsorption in Patients With Type II Diabetes and Healthy Controls

Boehringer Ingelheim

NCT01867307

COMPLETED Phase 2 38 participants

Diabetes Homeless Medication Support

Hennepin Healthcare Research Institute

NCT05258630

COMPLETED Phase 1 36 participants

A Study to Compare the Safety and Drug Levels in Blood When Using Various Forms of GSK189075 Given to Healthy Subjects

GlaxoSmithKline

NCT00559884

COMPLETED Phase 2 34 participants

Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

University of Missouri-Columbia

NCT03648996

COMPLETED NA 34 participants

Redox Imbalance and the Development of Cystic Fibrosis Diabetes

Emory University

NCT02202876

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Phase Distribution

PhaseTrial count
Phase 1 42
Phase 2 38
Phase 3 74
Phase 4 26

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Diabetes Mellitus, Type 2 Trial Landscape

351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).

Phase mix: 100 late (III/IV) vs 80 early (I/II).

Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Diabetes Mellitus, Type 2?

PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Diabetes Mellitus, Type 2?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.