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NCT00029588 · ClinicalTrials.gov registry record
Reward-Related Processes and Brain Function
A clinical trial of Depression, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 241
- Enrollment target
- 2
- Study locations
NCT00029588: Completed study of Depression, sponsored by National Institute of Mental Health (NIMH).
NCT00029588 is a study of Depression that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 241 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (69% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00029588, a study of Depression, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 241 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will examine and compare brain changes during decision-making in healthy adolescents and adolescents who are anxious or depressed. The findings may provide a better understanding of mechanisms that lead to depression or anxiety. Adolescents between 9 and 17 years of age and adults between 20 and 40 years of age in the following categories will be enrolled in this study: * Healthy adults * Healthy adolescents * Adolescents with major depression * Adolescents with anxiety disorder (generalized anxiety disorder, social phobia, or/and separation anxiety disorder) The study involves three visits, as follows: Visit 1 Visit 1 consists of three parts for both child and adult participants: * Part 1: Staff will meet with participants for a standard psychiatric interview, which will include questions about the participants feelings, experiences and behavior both past and present. For adolescent participants, staff will meet with the child alone, the parent alone, and the child and parent together. * Part 2: Participants will perform a series of simple tasks involving shapes, letters, and numbers. They will have a medical history, physical examination and blood draw. In addition, adolescents will have a urine drug test. * Part 3: Adults and those adolescents who will undergo magnetic resonance imaging (MRI) in Visit 3 will receive training to familiarize them with the procedure. Visit 2 * Adolescents will again be asked standardized questions regarding their feelings, experiences and behavior, and will then perform a series of simple decision-making tasks on a computer. * Adults will undergo MRI scanning, as described below in Visit 3 for adolescents. This concludes the participation of adults in the study. Visit 3 Adolescents will have one of the following two procedures: \- Decision-making task using a computer. Small electrodes will be placed on the child s wrists, face and fingers to monitor muscle tone and skin humidity during the task. Or * MRI, a
Conditions Studied
Study Locations (2)
District of Columbia
- Childrens National Medical Center - Washington D.C.
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 241 participants |
| Start Date | 2002-01-11 |
| Est. Completion | 2017-07-24 |
What the finished NCT00029588 record still lists
NCT00029588 is an observational study that tracks outcomes without assigning an intervention. The registered 241 participants enrollment target is mid-sized for trials with a published cap, below the 786-participant average among 679 other Depression trials with a reported enrollment target (69% lower).
The record links to 1 condition, with Depression appearing as the primary indexed condition, and to 0 interventions.
NCT00029588 reports a single indexed study location in District of Columbia, Maryland.
Frequently Asked Questions
What is clinical trial NCT00029588 about?
NCT00029588 is a clinical study titled "Reward-Related Processes and Brain Function". This study will examine and compare brain changes during decision-making in healthy adolescents and adolescents who are anxious or depressed. The findings may provide a better understanding of mechanisms that lead to depression or anxiety. Adolescents between 9 and 17 years of age and adults betwee...
What is the current status of trial NCT00029588?
This trial is currently completed. The enrollment target is 241 participants. The study started on 2002-01-11. Estimated completion is 2017-07-24.
What conditions does trial NCT00029588 study?
This clinical trial studies the following conditions: Depression.
Who is sponsoring clinical trial NCT00029588?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00029588 being conducted?
This trial has 2 study locations across District of Columbia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00029588's enrollment target sits among peer trials
241 176th of 679 higher than 504 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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