Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05029726 · ClinicalTrials.gov registry record · Phase 4
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
A Phase 4 study of Degenerative Disc Disease and Lumbar Spinal Stenosis, sponsored by John O'Toole.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 125
- Enrollment target
- 1
- Study location
NCT05029726: Recruiting Phase 4 study of Degenerative Disc Disease and Lumbar Spinal Stenosis, sponsored by John O'Toole.
NCT05029726 is a Phase 4 study of Degenerative Disc Disease and Lumbar Spinal Stenosis that is actively recruiting participants, run by John O'Toole. The registered enrollment target is 125 participants, below the 166-participant average among 42 other Degenerative Disc Disease trials with a reported enrollment target (25% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05029726, a Phase 4 study of Degenerative Disc Disease and Lumbar Spinal Stenosis, is actively recruiting participants, sponsored by John O'Toole.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 125 participants
- Enrollment target
- 1
- Study location
Study Summary
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.
Primary Outcome
Mean per day inpatient opioid consumption in morphine milligram equivalents (MME)
Conditions Studied
Interventions
- DRUG Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine
- DRUG normal saline
Study Locations (1)
Illinois
- Rush University Medical Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 125 participants |
| Start Date | 2022-02-01 |
| Est. Completion | 2027-04-30 |
| Phase | Phase 4 |
What NCT05029726 shows while recruiting
NCT05029726 is an interventional study that assigns participants to a tested intervention. The registered 125 participants enrollment target is mid-sized for trials with a published cap, below the 166-participant average among 42 other Degenerative Disc Disease trials with a reported enrollment target (25% lower).
The record links to 10 conditions, with Degenerative Disc Disease appearing as the primary indexed condition, and to 2 interventions - of which Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine is the first listed.
NCT05029726 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT05029726 about?
NCT05029726 is a clinical study titled "Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery". Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical p...
What is the current status of trial NCT05029726?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 125 participants. The study started on 2022-02-01. Estimated completion is 2027-04-30.
What conditions does trial NCT05029726 study?
This clinical trial studies the following conditions: Degenerative Disc Disease, Lumbar Spinal Stenosis, Degenerative Spondylolisthesis, Lumbar Spondylosis, Lumbar Disc Herniation.
What interventions are being tested in trial NCT05029726?
The interventions under investigation include: Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine (DRUG), normal saline (DRUG).
Who is sponsoring clinical trial NCT05029726?
This trial is sponsored by John O'Toole, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05029726 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Degenerative Disc Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05029726's enrollment target sits among peer trials
125 17th of 42 higher than 26 of 42 other Degenerative Disc Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Degenerative Disc Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
OssDsign® Spine Registry Study ("Propel")
RECRUITING
-
A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease
RECRUITING · Phase 3
-
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
RECRUITING · Phase 1
-
Investigation of DEXA-C Anterior Cervical Interbody System
RECRUITING · NA
-
Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion
RECRUITING · NA
-
Trial for Treating Painful Degenerative Disc Disease
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02717039 · 125 participants
Pharmacogenomics of Heparin-Induced Thrombocytopenia
- NCT02763033 · 125 participants · Phase 2
Dietary Manipulation of the Microbiome-metabolomic Axis for Mitigating GVHD in Allo HCT Patients
- NCT02793999 · 125 participants
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
- NCT03003299 · 125 participants · NA
PARTNER 3 Trial - Aortic Valve-in-Valve
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI